A Phase 1, Randomized, Double-blind, Placebo-controlled, Single Ascending Dose Study Designed to Compare the Safety and Pharmacokinetics of Orally Administered Superoxide Dismutase Mimetic GC4702 With Intravenously Administered Superoxide Dismutase Mimetic GC4419 (Part 1), With Assessment of Food Effect (Part 2), in Healthy Volunteers

A Phase 1 study will test the safety, tolerability and pharmacokinetics of a single dose of GC4702 when given as an oral tablet. This study will compare capsules containing a dry powder or gel suspension of GC4702 when given orally to a similar drug called GC4419 which will be given as an intravenous infusion. This study will also assess the effect of food on the GC4702 effects.

开始日期2016-07-26

申办/合作机构

Galera Therapeutics, Inc.

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100 项与 GC-4702 相关的临床结果

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100 项与 GC-4702 相关的转化医学

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100 项与 GC-4702 相关的专利（医药）

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项与 GC-4702 相关的文献（医药）

2022-02-01·Pain1区 · 医学

Nitroxidative stress in pain and opioid-induced adverse effects: therapeutic opportunities

1区 · 医学

Article

作者: Salvemini, Daniela ; Squillace, Silvia

A review.Pathol. pain states arising from injuries to the nervous system are characterized by sustained neuroinflammation and increased neuronal excitability at both peripheral and central level.Overproduction of reactive oxygen and nitrogen (nitroxidative) species, such as superoxide (SO) and peroxynitrite (PN, ONOO-), and impaired endogenous antioxidant defenses play critical roles in triggering chronic pain states.In particular, a growing body of evidence indicates a major involvement of SO and PN in inflammatory and neuropathic pain states as well as in the development of increased pain sensitivity during prolonged opioid use (opioid-induced hyperalgesia).Stable and selective compounds have been developed as novel therapeutic strategies to target nitroxidative stress in pain settings.Superoxide dismutase mimetics (eg, GC4419, GC4711, and GC4702) as well as PNDCs and RSDAx, such as SRI compounds and ACP-044, displayed promising results in preclin. studies and most of them are now advancing in clin. trials.Interestingly, increased NOS activity or PN formation has been recently linked to neurovascular dysfunction and lipid peroxidation underlying the pathophysiol. of depression, anxiety, and cognitive dysfunction all common comorbidities of chronic pain states.This suggests that targeting nitroxidative stress may have beneficial outcomes on multiple components of pain.

100 项与 GC-4702 相关的药物交易

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