Development of the new potent non-peptide gpIIb/IIIa antagonist NSL-95301 by utilizing combinatorial technique
作者: Yoshio Hayashi ; Iwao Ojima ; Akira Tachiki ; Isao Uno ; Jun Katada ; Kiyoko Iijima ; Takeo Harada ; Tohru Asari
The synthetic study of new non-peptide gpIIb/IIIa antagonist, NSL-95301, is presented.The combinatorial technique was engaged in the lead compound discovery process and optimization process to find (+)-NSL-95301.The IC50 value of collagen induced platelet aggregation inhibitory activity is 92 nM.