4区 · 医学
Article
作者: Kawamura, Asuka  ; Ohata, Yasuo  ; Arakawa, Naohisa  ; Shimada, Kousei  ; Matsuda, Fumihiko  ; Abe, Yuki  ; Kitano, Yutaka  ; Inoue, Tatsuya  ; Deguchi, Tsuneo  ; Kobayashi, Jun  ; Domon, Yuki  ; Onishi, Yoshiyuki 
We identified novel (3R, 5S)-3-aminomethyl-5-methanesulfanyl hexanoic acid (5a: DS75091588) and (3R, 5S)-3-aminomethyl-5-ethanesulfanyl hexanoic acid (6a: DS18430756) as sulfur-containing γ-amino acid derivatives that were useful for the treatment of neuropathic pain. These two compounds exhibited a potent analgesic effect in animal models of both type I diabetes and type II diabetes, and good pharmacokinetics.