4区 · 医学
Article
作者: Kawamura, Asuka ; Ohata, Yasuo ; Arakawa, Naohisa ; Shimada, Kousei ; Matsuda, Fumihiko ; Abe, Yuki ; Kitano, Yutaka ; Inoue, Tatsuya ; Deguchi, Tsuneo ; Kobayashi, Jun ; Domon, Yuki ; Onishi, Yoshiyuki
We identified novel (3R, 5S)-3-aminomethyl-5-methanesulfanyl hexanoic acid (5a: DS75091588) and (3R, 5S)-3-aminomethyl-5-ethanesulfanyl hexanoic acid (6a: DS18430756) as sulfur-containing γ-amino acid derivatives that were useful for the treatment of neuropathic pain. These two compounds exhibited a potent analgesic effect in animal models of both type I diabetes and type II diabetes, and good pharmacokinetics.