KF-19418(KF-19418) - _专利_临床

概要

基本信息

药物类型

小分子化药

别名

靶点-

作用机制-

治疗领域

皮肤和肌肉骨骼疾病

在研适应症-

非在研适应症

脱发

原研机构

Kyowa Kirin Co., Ltd.

在研机构-

非在研机构

Kyowa Kirin Co., Ltd.

最高研发阶段终止临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构

分子式C21H14N4O

InChIKeyUUTQKSICTCJBNB-UHFFFAOYSA-N

CAS号147508-06-3

关联

100 项与 KF-19418 相关的临床结果

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100 项与 KF-19418 相关的转化医学

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100 项与 KF-19418 相关的专利（医药）

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1

项与 KF-19418 相关的文献（医药）

2001-04-01·Journal of Dermatological Science2区 · 医学

KF19418, a new compound for hair growth promotion in vitro and in vivo mouse models

2区 · 医学

Article

作者: Jun-ichi Ikeda ; Tatsuya Tamaoki ; Akio Shirai ; Sagano Kawashima ; Toshikazu Kamiya

KF19418, a newly synthesized compound, stimulated proliferation of cultured hair bulb cells from new born mice in concentration-dependent manner in the range under 10 microM. In the culture system of whole skin pieces from 4-week-old mice which we earlier established, KF19418 promoted hair follicle elongation as in the case of minoxidil. After topical application for 2 weeks of KF19418 or minoxidil to dorsal skin of hair-clipped mouse alopecia model, KF19418 at 1% suspension accelerated hair regrowth at a rate comparable to 1% minoxidil solution. Thus, it was shown that KF19418 directly stimulated hair follicle in vitro and had hair growth promoting activities in vivo.

100 项与 KF-19418 相关的药物交易

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