In this study, eight new natural products were isolated from the leaves of Picrasma quassioides. Spectroscopic techniques were used for the elucidation of their planar structures. Their absolute configurations were elucidated on the basis of electron circular dichroism (ECD) techniques combined with the P/M helicity rule for the 2,3-dihydrobenzofuran chromophore, and saccharide hydrolysis. Cholinesterase inhibitors are often used as Alzheimer's disease inhibitors.Thus, acetylcholinesterase and butyrylcholinesterase inhibitory activity of these eight compounds were tested, and results showed that only compound 6 showed weakly acetylcholinesterase inhibitory activity. In particular, molecular docking was used to illustrate the bindings between compound 6 and the active sites of AChE.

2012-09-01·Pharmacoepidemiology and drug safety4区 · 医学

Use of drug treatments for Alzheimer's disease in France: a study on a national level based on the National Alzheimer's Data Bank (Banque Nationale Alzheimer)

4区 · 医学

Article

作者: Pradier, Christian ; Robert, Philippe ; Quantin, Catherine ; Quetel, Julien ; Benzenine, Eric ; Duff, Franck Le ; Schück, Stéphane ; Tifratene, Karim ; Lafay, Pierre

ABSTRACT:

Purpose:

To examine the way in which specific drug treatments for Alzheimer's disease are used and whether their use complies with clinical practice guidelines issued by the French National Authority for Health in patients with Alzheimer's disease.

Methods:

We analysed a cross‐section of the French National Alzheimer's databank (BNA). Participants were individuals who consulted centres contributing to the BNA in 2010 and diagnosed with Alzheimer's disease and with at least one Mini Mental State Examination (MMSE) score recorded during the course of the year.

Results:

Of 191 919 consultations recorded in the database, 29.9% involved a diagnosis of Alzheimer's disease, and 26 809 patients had completed at least one MMSE. In 76.9% of cases, treatment was given with an anti‐Alzheimer's drug. Monotherapy with an acetylcholinesterase inhibitor was prescribed for 48.3% of patients, monotherapy with memantine in 14.2% and dual therapy in 14.4% of cases. Treatment given did not comply with the guidelines in 20.7% of cases. Prescriptions not complying with the guidelines were associated with a lower mean MMSE score (13.6 vs. 18.0; p < 0.00001) and more cases of treatment with antidepressants (29.2% vs. 22.8%; p < 0.00001), anxiolytics (14.7% vs. 12.3%; p < 0.00001) and antipsychotics (8.7% vs. 4.9%; p < 0.00001).

Conclusion:

Four of five prescriptions for treatment with anti‐Alzheimer's drugs complied with the specific drug treatment chapter of the 2008 French clinical guidelines. Prescriptions not complying with the guidelines for acetylcholinesterase inhibitors and memantine were usually issued in situations involving advanced‐stage Alzheimer's disease. The BNA can provide precise information on medical practice in Alzheimer's disease and related disorders. Copyright © 2012 John Wiley & Sons, Ltd.

2010-01-01·Molecular bioSystems

Rapid and efficient screening of Alzheimer's disease β-amyloid inhibitors using label-free gold nanoparticles

Article

作者: Qu, Konggang ; Qu, Xiaogang ; Geng, Jie ; Ren, Jinsong

Herein we report that a visual, label-free gold nanoparticle-based assay for rapid and efficient screening of Alzheimer's disease β-amyloid inhibitors.

100 项与 Alzheimer's disease immunotherapy (Emergent BioSolutions) 相关的药物交易

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