更新于：2024-09-19

Emorfazone

依莫法宗

更新于：2024-09-19

概要

概要

基本信息

药物类型

小分子化药

别名

Emorfazone (JP17/INN)、Pentoil

靶点-

作用机制-

治疗领域

神经系统疾病其他疾病

在研适应症-

非在研适应症

炎症疼痛

原研机构

Clariant AG

在研机构-

非在研机构-

最高研发阶段撤市

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构

分子式C11H17N3O3

InChIKeyURJQOOISAKEBKW-UHFFFAOYSA-N

CAS号38957-41-4

关联

100 项与依莫法宗相关的临床结果

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100 项与依莫法宗相关的转化医学

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100 项与依莫法宗相关的专利（医药）

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项与依莫法宗相关的文献（医药）

2003-11-01·Il Farmaco

4-Amino-3(2H)-pyridazinones bearing arylpiperazinylalkyl groups and related compounds: synthesis and antinociceptive activity

Article

作者: Mark A Scheideler ; Vittorio Dal Piaz ; Giuseppe Petrone ; Claudia Vergelli ; Maria Paola Giovannoni ; Paola Zaratin

A series of 4-amino-3(2H)-pyridazinones substituted at position 2 with arylpiperazinylalkyl groups and analogues were synthesized and their antinociceptive effect was evaluated in the mouse abdominal constriction model. Preliminary SARs studies were performed. Several of the novel compounds dosed at 100 mg/kg s.c. significantly reduced the number of writhes induced by the noxious stimulus. Compound 12e showed 100% inhibition of writhes and was able to protect all the treated animals from the effect of the chemical stimulus. Subsequent dose-response studies revealed 12e to be almost 40-fold more potent than the structurally related Emorfazone.

1994-01-01·YAKUGAKU ZASSHI4区 · 医学

ピリダジノン誘導体の研究(第16報)3(2H)-ピリダジノン誘導体の合成と鎮痛消炎作用

4区 · 医学

Article

作者: Sato, Makoto ; Takaya, Masahiro

In order to examine analgesic and antiinflammatory activities of the position isomers of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (1, emorfazone), an analgesic-antiinflammatory drug, 5-ethoxy-2-methyl-4-morpholino-3(2H)-pyridazinone (2), 6-ethoxy-2-methyl-4-morpholino-3(2H)-pyridazinone (3) and 6-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (4) were prepared. Since 4 showed the most strong activity among the compounds tested, various 6-alkoxy- or 6-allyloxy-2-alkyl- or 2-cyclohexyl- or 2-phenyl-5-substituted amino-3(2H)-pyridazinones (15, 16) were prepared and examined for their activities. As a result, 4 and 2-methyl-5-morpholino-6-n-propoxy- or 6-n-butoxy-3(2H)-pyridazinone (15b, c) and 6-ethoxy-2-ethyl-5-morpholino-3(2H)-pyridazinone (15 l) were revealed to be more potent in analgesic and antipyretic activities than commercial drugs (1, aminopyrine, mepirizole, tiaramide HCl, phenylbutazone, mefenamic acid). On the basis of the available data, the structure-activity relationship in a series of 6-alkoxy-2-alkyl-5-substituted amino-3(2H)-pyridazinones (15, 16) was also discussed.

1992-01-01·JPMA. The Journal of the Pakistan Medical Association4区 · 医学

Double blind study on emorfazone and ibuprofen in dental pain and inflammation.

4区 · 医学

Article

作者: Malik, S ; Khan, A A ; Zuberi, N I

100 项与依莫法宗相关的药物交易

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