茯苓飲(Fuling Yin) - 在研适应症：厌食症，消化不良，胃扩张_专利_临床

概要

基本信息

药物类型

中药

别名

コタロー茯苓飲エキス細粒

靶点-

作用机制-

治疗领域

消化系统疾病其他疾病

在研适应症

厌食症消化不良胃扩张+ [3]

非在研适应症-

原研机构

Kotaro pharmaceutical Co Ltd.

在研机构

Kotaro pharmaceutical Co Ltd.

非在研机构-

最高研发阶段批准上市

首次获批日期

日本 (1986-10-30),

厌食症消化不良胃扩张+ [3]

最高研发阶段(中国)-

特殊审评-

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关联

100 项与茯苓飲相关的临床结果

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100 项与茯苓飲相关的转化医学

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100 项与茯苓飲相关的专利（医药）

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1

项与茯苓飲相关的文献（医药）

2011-09-01·Journal of Molecular Graphics and Modelling4区 · 生物学

Insight into mechanism of small molecule inhibitors of the MDM2–p53 interaction: Molecular dynamics simulation and free energy analysis

4区 · 生物学

Article

作者: Jinan Wang ; Beisi Xu ; Weiliang Zhu ; Guohui Li ; Jianzhong Chen

Inhibition of the MDM2-p53 interaction is considered to be a new therapeutic strategy to activate wild-type p53 in tumors. Molecular dynamics (MD) simulations followed by molecular mechanics generalized Born surface area (MM-GBSA) analyses were used to study the inhibitory mechanisms of four small molecule inhibitors, K23, YIN, DIZ and IMZ on the p53-MDM2 interaction. We found excellent agreement between the rank of the calculated absolute binding free energies using the MM-GBSA method and the experimentally determined rank. The results show that van der Waals energy is the dominant factor for the binding of the four inhibitors. Statistical analyses of the hydrophobic contacts between the inhibitors and MDM2 were performed, and the results suggested that these inhibitors form stable hydrophobic interactions with six residues of MDM2: Leu54, Gly58, Ile61, Met62, Val93 and His96. Calculations of the detailed van der Waals interactions between non-peptide inhibitors and individual protein residues can provide insights into the inhibitor-protein binding mechanism. Our studies suggest that the CH-π and π-π interactions between the four inhibitors and protein residues drive binding of the inhibitors in the hydrophobic cleft of MDM2.

100 项与茯苓飲相关的药物交易

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研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
厌食症	日本	Kotaro pharmaceutical Co Ltd.	1986-10-30
消化不良	日本	Kotaro pharmaceutical Co Ltd.	1986-10-30
胃扩张	日本	Kotaro pharmaceutical Co Ltd.	1986-10-30
胃炎	日本	Kotaro pharmaceutical Co Ltd.	1986-10-30
胃下垂	日本	Kotaro pharmaceutical Co Ltd.	1986-10-30
呕吐	日本	Kotaro pharmaceutical Co Ltd.	1986-10-30