Adherence and Effectiveness of MoviPrep<sup>®</sup> in Bowel Preparation for Colonoscopy: A Multicenter Study from the Hiroshima GI Endoscopy Research Group

Article

作者: Kunihiro, Masaki ; Hiraga, Yuko ; Kawamura, Toru ; Ohnishi, Mayu ; Matsuo, Taiji ; Asayama, Naoki ; Kuroda, Tsuyoshi ; Oka, Shiro ; Aoyama, Taiki ; Tanaka, Shinji ; Nakadoi, Koichi ; Nagata, Shinji

ObjectivesBowel preparation is burdensome because of long cleansing times and large dose volumes of conventional polyethylene glycol (PEG) lavage solution Niflec^Ⓡ (Nif). MoviPrep (Mov)^Ⓡ is a hyperosmolar preparation of PEG, electrolytes, and ascorbic acid; despite the smaller dose volume of 2 L, it can be challenging for many patients. We examined a more effective and acceptable bowel preparation method without compromising cleanliness and effectiveness, combining low-residue diet and laxative (Modified Brown Method) in Mov administered 1 day pre-colonoscopy.MethodsThis multicenter, randomized, open-label, parallel-group comparative study, conducted at Hiroshima University Hospital and 7 affiliated hospitals in May 2015-March 2016, evaluated adherence to and effectiveness of Mov in bowel preparation. Participants (n=380) were allocated to receive 1 of 3 pre-colonoscopy regimens: Nif+Modified Brown Method (Group A), Mov+Modified Brown Method (Group B), or Mov+Laxative (Group C).ResultsTotal intake volume showed no significant difference among the groups. Bowel preparation time was significantly shorter in Group B (112.4±44.8 min, n=118) than in Groups A (131.3±59 min, n=105) and C (122.6±48.1 min, n=115). Sleep disturbance (37%) was significantly higher in Group B than Group A; distension (11%) was significantly lower in Group C than in Groups A and B (p<0.05, respectively). No severe adverse events occurred in any group.ConclusionsMov+Modified Brown method provided significantly shorter bowel preparation time, with no significant difference in total intake volume among the regimens. Mov+Laxative yielded significantly less distension than the other groups, with bowel preparation equivalent to that of the Nif+Modified Brown method.

2019-01-01·Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

[Anaphylactic shock secondary to the use of macrogol 4000 as a bowel cleanser:a case report].

Article

作者: Sanomura, Tamana ; Iishi, Hiroyasu ; Ouchi, Shohei ; Tsutsui, Shusaku ; Horiki, Masashi ; Imanaka, Kazuho ; Murayama, Yoko ; Seto, Kayo ; Ogiyama, Hideharu ; Nasu, Ayaka

A 44-year-old man was administered Niflec^® containing macrogol 4000 as a bowel cleanser for colonoscopic examination. Immediately after ingestion, he experienced oral cavity discomfort and nasal congestion, followed by acute urticaria and presyncope. His systolic blood pressure and peripheral capillary oxygen saturation dropped to 66mmHg and 89%, respectively. Fluid infusion, as well as steroid and epinephrine administration, improved his symptoms. Skin prick tests were then performed using Niflec^®, macrogol 4000, and Actosin^® ointment (containing macrogol 4000), all of which were positive. Therefore, the patient was diagnosed with anaphylactic shock caused by macrogol 4000 included in Niflec^®. Macrogol present in bowel cleansers used for colonoscopy rarely causes anaphylactic shock. However, clinicians need to be mindful of this risk. Prompt and appropriate treatment is needed should this condition occur.

Case Reports in Gastroenterology

Colonic Diverticular Bleeding Associated with Bowel Cleansers before Colonoscopy

作者: Kubo, Kimitoshi ; Kato, Mototsugu ; Tsuda, Momoko ; Kimura, Noriko ; Matsuda, Soichiro

To date, colonic diverticular bleeding associated with bowel cleansers has not been reported, and its endoscopic and pathological features remain largely unclear. We report a case of colonic diverticular bleeding associated with a bowel cleanser (137 g of polyethylene glycol [NIflec®]) before colonoscopy (CS). CS revealed colonic diverticular bleeding in the sigmoid colon. To our knowledge, this is the first report describing the endoscopic and pathological features of colonic diverticular bleeding associated with bowel cleansing before CS.

100 项与氯化钠/氯化钾/碳酸氢钠/无水硫酸钠/聚乙二醇4000 相关的药物交易

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