NBS-004(NBS-004) - _专利_临床

概要

基本信息

药物类型

小分子化药

别名

靶点-

作用机制-

治疗领域

肿瘤

在研适应症-

非在研适应症

肿瘤

原研机构

Novintum Bioscience Ltd.

在研机构-

非在研机构

Novintum Bioscience Ltd.

最高研发阶段终止药物发现

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 NBS-004 相关的临床结果

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100 项与 NBS-004 相关的转化医学

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100 项与 NBS-004 相关的专利（医药）

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1

项与 NBS-004 相关的文献（医药）

2022-02-14·Inorganic Chemistry2区 · 化学

Synthesis and Structure of Quasi-One-Dimensional Niobium Tetrasulfide NbS₄

2区 · 化学

Article

作者: Poltarak, Pavel ; Komarov, Vladislav ; Enyashin, Andrey ; Poltarak, Anastasiia ; Artemkina, Sofya ; Fedorov, Vladimir

The binary niobium sulfide NbS₄ was synthesized as a crystalline phase. We showed that NbS₄ can be formed from Nb metal, from defect niobium sulfide Nb_1.14S₂, or from some other niobium dichalcogenides in reactions with excess sulfur in an evacuated ampule at 440 °C. The crystal structure of NbS₄ (monoclinic space group C2/c, a = 13.126(2) Å, b = 10.454(1) Å, c = 6.951(1) Å, β = 111.939(5)°) is a packing of infinite chains {NbS₄}_1∞, analogous to VS₄. In the chains, Nb atoms are in a tetragonal-antiprismatic coordination of sulfur atoms of disulfide groups (S₂)^2-; short Nb···Nb contacts (2.896 Å) alternating with longer ones (3.278 Å) appear within the chains at 150 K. According to density functional theory calculations, NbS₄ is a thermodynamically stable compound, a nonmagnetic semiconductor. NbS₄ is a new member of the family of quazi-one-dimensional compounds, group 5 metal polychalcogenides, well-known for their interesting electrophysical properties. The synthesis and crystal structure as well as the thermal stability and lattice dynamics of NbS₄ are discussed here.

100 项与 NBS-004 相关的药物交易

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