Stepronin(Stepronin) - 在研适应症：鼻窦炎，支气管炎，鼻咽炎_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Broncoplus、Masor、Mucodil

+ [9]

靶点-

作用机制

溶菌剂

治疗领域

感染口颌疾病耳鼻咽喉疾病+ [1]

在研适应症

鼻窦炎支气管炎鼻咽炎+ [1]

非在研适应症-

原研机构

Alfasigma SpA

在研机构

Sigma-Tau Industrie Farmaceutiche Riunite SpA

Alfasigma SpA

Innothera SA

+ [5]

非在研机构-

最高研发阶段批准上市

首次获批日期

意大利 (1981-07-01),

支气管炎鼻咽炎呼吸障碍

最高研发阶段(中国)-

特殊审评-

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结构

分子式C10H11NO4S2

InChIKeyJNYSEDHQJCOWQU-UHFFFAOYSA-N

CAS号72324-18-6

关联

100 项与 Stepronin 相关的临床结果

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100 项与 Stepronin 相关的转化医学

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100 项与 Stepronin 相关的专利（医药）

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17

项与 Stepronin 相关的文献（医药）

1999-12-01·Transplantation Proceedings4区 · 医学

Anti–human immunodeficiency virus activity of a new immunosuppressant drug called Stepronin

4区 · 医学

Article

作者: J.A Habeshaw ; L de Giorgi ; J.S Oxford ; K Broadhurst ; P Carminati

The cellular toxicity and anti-human immunodeficiency virus (HIV)-1 activity of stepronin was evaluated.Zidovudine (AZT) and suitable drug-free controls were used in assays with peripheral blood mononuclear cells (PBMC) and monocyte-derived continuous cell lines U937 and CEM-4.Stepronin affected the lice cycle of HIV-1 in infected cultured cells.An antiviral activity was measured by inhibition of viral p24 antigen productionAt a concentration of 10 μmol/L, an increment of viral p24 antigen was observedThe inhibition of HIV-1 by this drug was not dose-dependent in a linear fashion, as inhibition is for HIV-1 by AZT.

1996-04-01·Allergy1区 · 医学

Accelerated cell‐mediated broncho‐obstructive reaction to inhaled stepronin: a case report

1区 · 医学

Article

作者: M. Di Fonso ; A. Romano ; F. Giuffreda ; F. Mormile ; D. Quaratino ; A. Venuti

We describe the case of a 20‐year‐old man who developed an obstructive bronchial reaction accompanied by a maculopapular facial rash 8 h after an aerosol treatment with the mucolytic drug stepronin. The results of intradermal and patch testing with stepronin, together with those of bronchial challenge and histologic findings in patch‐tested skin, indicate that the patient's reaction involved an accelerated cell‐mediated mechanism of hypersensitivity. Bronchial challenges with methacholine demonstrated a transient increase in nonspecific bronchial hyperreactivity.

1994-12-01·Transplantation proceedings

Immunosuppressive effect of stepronin (TS-5010680) in mice.

Article

作者: de Giorgi, L ; Arrigoni-Martelli, E ; Matossian-Rogers, A

100 项与 Stepronin 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D07381	Stepronin	R05CB11	DB01423

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
鼻窦炎	意大利	Alfasigma SpA	2015-05-18
支气管炎	意大利	Sigma-Tau Industrie Farmaceutiche Riunite SpA	1981-07-01
鼻咽炎	意大利	Sigma-Tau Industrie Farmaceutiche Riunite SpA	1981-07-01
鼻咽炎	意大利	Alfasigma SpA	1981-07-01
呼吸障碍	意大利	Glaxo Wellcome Plc	1981-07-01
呼吸障碍	意大利	Pierrel SpA	1981-07-01
呼吸障碍	意大利	Fournier Pharma SA	1981-07-01