Functional Consequences of T-bet Expression in Flu-specific Memory B Cells After Live Attenuated Influenza Vaccine (LAIV)
As yet the investigators do not understand if there are biomarkers of immune protection after the Flumist or Live Attenuated Flu Vaccine (LAIV). Here the investigators test the hypothesis that the T-bet expressing fraction of flu-specific B cells after live attenuated influenza vaccination also serves as an early biomarker of long-lived antibody responses after vaccination. In this study the investigators will be providing the LAIV to up to 10 healthy subjects and assaying their immune response and then providing the intramuscular influenza vaccination and testing to see if the immune protection after the LAIV also protects after the intramuscular influenza vaccination. Update: We have amended this protocol to study the antigen-specific B cell populations that circulate after LAIV or IIV prime and LAIV or IIV boost.
100 项与 Live Attenuated Flu Vaccine(University of Alabama at Birmingham) 相关的临床结果
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100 项与 Live Attenuated Flu Vaccine(University of Alabama at Birmingham) 相关的转化医学
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100 项与 Live Attenuated Flu Vaccine(University of Alabama at Birmingham) 相关的专利(医药)
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2
项与 Live Attenuated Flu Vaccine(University of Alabama at Birmingham) 相关的文献(医药)
2005-11-01·Journal of Public Health Management and Practice4区 · 医学
Evolving Recommendations for Vaccinating the Immunocompromised Patient
4区 · 医学
Article
作者: Bhatt, Achal ; Wolfe, Skip
This article describes smallpox vaccination in the immunocompromised, the use of live attenuated flu vaccine in the immunocompromised, and the appearance of a new adult vaccination schedule.
2000-04-12·JAMA
Merits, Flaws of Live Virus Flu Vaccine Debated
作者: Marwick, Charles
100 项与 Live Attenuated Flu Vaccine(University of Alabama at Birmingham) 相关的药物交易