TO THEEDITOR: In 1984, Sokal et al 1 developed a scoring system to predict the outcome of patients with chronic myeloid leukemia (CML). The scoring system rapidly gained popularity and has remained until now the most widely accepted method for assessing prognosisforpatientswithCML.AlthoughtheSokalscorewasdeveloped for patients with nonblastic disease who were treated with hydroxyureaorbusulfan,italsoprovedusefulforpredictingthesurvival of patients treated with interferon 2 and can predict the outcome for patients treated with imatinib. 3,4 Interestingly, it also predicts the outcome for patients who receive imatinib after experiencing treatment failure with interferon 5 and for patients who receive secondgeneration tyrosine kinase inhibitors after experiencing treatment failurewithimatinib. 6 TheconsistentvalueoftheSokalscoringsystem