Some antibiotics are also effective against malaria parasites. Fosmidomycin is an antibiotic that has been shown to be effective against malaria, although it cannot achieve a total cure in all patients. A previous small study has shown that in combination with clindamycin, an commonly used antibiotic, it is highly effective and safe, in asymptomatic carriers of malaria parasites. The current study will evaluate the efficacy and safety of the combination given for three days in children with uncomplicated malaria in Gabon.

开始日期2002-06-01

申办/合作机构

The Albert Schweitzer Fellowship

100 项与克林霉素磷酸酯/膦胺霉素相关的临床结果

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100 项与克林霉素磷酸酯/膦胺霉素相关的转化医学

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100 项与克林霉素磷酸酯/膦胺霉素相关的专利（医药）

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项与克林霉素磷酸酯/膦胺霉素相关的文献（医药）

1989-01-01·Journal of Antimicrobial Chemotherapy2区 · 医学

Inhibition of bacterial isoprenoid synthesis by fosmidomycin, a phosphonic acid-containing antibiotic

2区 · 医学

Article

作者: Shigi, Y

The mechanism of action of fosmidomycin (FR-31564), a phosphonic acid containing antibiotic, was examined against Escherichia coli, Micrococcus luteus and other bacteria. It converted growing Esch. coli cells into spheroplasts or swollen cells, but did not inhibit the enzymatic reactions of cell wall synthesis in ether-treated cells. Unlike bicyclomycin, phenethyl alcohol and mitomycin C, it did not reduce the amount of envelope lipoprotein, phospholipids, or DNA, but did reduce the amount of menaquinones and ubiquinones in growing Esch. coli cells. It also inhibited the biosynthesis of both carotenoids and menaquinones in M. luteus cells, suggesting that inhibition of the biosynthesis of a common precursor of these isoprenoids (possibly farnesyl pyrophosphate) might be the main site of its antibacterial activity.

1982-10-01·Antimicrobial Agents and Chemotherapy2区 · 医学

Synergy of fosmidomycin (FR-31564) and other antimicrobial agents

2区 · 医学

Article

作者: Kamimura, Toshiaki ; Neu, Harold C.

Fosmidomycin (FR-31564), a phosphonic acid derivative, was combined with cefazolin, cephalexin, ampicillin, carbenicillin, ticarcillin, gentamicin, and trimethoprim. Synergy between fosmidomycin and penicillins or cephalosporins was found for 37 to 52% of the Enterobacteriaceae tested. Synergy with trimethoprim was found against 55% of bacteria isolated, but only 17% of the strains showed synergy between formidomycin and gentamicin. Synergy between fosmidomycin and ticarcillin was shown for 35% of the Pseudomonas isolates. Cefazolin-, ampicillin-, and gentamicin-resistant isolates of various species were synergistically inhibited by fosmidomycin, as were ticarcillin- and gentamicin-resistant isolates. Antagonism was not encountered. This study illustrates another example of synergistic activity of compounds which attack different mechanisms in bacterial cells.

100 项与克林霉素磷酸酯/膦胺霉素相关的药物交易

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