Noro Virus Vaccine(Vernagen)(Noro Virus Vaccine(Vernagen)) - 药物靶点：norovirus 3CL protease_在研适应症：诺如病毒感染_专利_临床

概要

基本信息

药物类型

预防性疫苗、mRNA疫苗

别名-

靶点

norovirus 3CL protease

作用机制

norovirus 3CL protease抑制剂(诺如病毒3CL蛋白酶抑制剂)、免疫刺激剂

治疗领域

感染

在研适应症

诺如病毒感染

非在研适应症-

原研机构

Vernagen Inc.

在研机构

Vernagen Inc.

University of Michigan College of Engineering

非在研机构-

最高研发阶段药物发现

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 Noro Virus Vaccine(Vernagen) 相关的临床结果

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100 项与 Noro Virus Vaccine(Vernagen) 相关的转化医学

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100 项与 Noro Virus Vaccine(Vernagen) 相关的专利（医药）

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1

项与 Noro Virus Vaccine(Vernagen) 相关的文献（医药）

1985-09-01·Acta Academiae Medicinae Wuhan

Morphological studies on the mechanism of anti-implantative and early-pregnancy-terminative effect by norethisterone oxime in rats

Article

作者: Yi-di Yang ; Ling Peng

In this study it was found that norethisterone oxime (NorO) could produce changes in some organelles of the ovarian corpora lutea in early pregnant rats including decrease in smooth endoplasmic reticulum, accumulation of lipid droplets, swelling of Golgi bodies and increase in secondary lysosomes. NorO also depressed the activity of 3β-hydroxysteroid dehydrogenase in the ovary, resulting in the obstruction of biological synthesis of steroid hormone in the ovary. It was found that the activity of acid phosphatase of the corpora lutea increased, which showed an increase in the membrane permeability of lysosomes and damage to the cells. Morphological changes unfavourable to implantation occurred in the endometrium of the early pregnant rats, such as, decrease in the transformation of stroma cells into decidual cells, degeneration and necrosis of the decidual cells. On the 4th day of pregnancy estrogenic effect could be detected in the endometrium of the rats. Further study should be made to determine whether this is due to the depression of progesterone level by NorO and thereafter less depression of the action of estrogen or due to the estrogenic activity of the drug itself.

100 项与 Noro Virus Vaccine(Vernagen) 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
诺如病毒感染	药物发现	美国	University of Michigan College of Engineering	2024-04-01
诺如病毒感染	药物发现	美国	Vernagen Inc.	2024-04-01