唑拉西泮(Zolazepam) - 药物靶点：GABAA receptor_在研适应症：麻醉_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Flupyrazapon

靶点

GABAA receptor

作用方式

调节剂

作用机制

GABAA receptor调节剂(γ-氨基丁酸 A 受体调节剂)

治疗领域

其他疾病

在研适应症

麻醉

非在研适应症-

原研机构

Parke-Davis & Co. Ltd.

在研机构

Parke-Davis & Co. Ltd.

非在研机构-

权益机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构/序列

分子式C15H15FN4O

InChIKeyGDSCFOSHSOWNDL-UHFFFAOYSA-N

CAS号31352-82-6

关联

100 项与唑拉西泮相关的临床结果

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100 项与唑拉西泮相关的转化医学

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100 项与唑拉西泮相关的专利（医药）

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420

项与唑拉西泮相关的文献（医药）

2026-04-01·VETERINARY RESEARCH COMMUNICATIONS

Electrocardiographic parameters and heart rate variability analysis in free-ranging female South American Coatis (Nasua nasua)

Article

作者: Felichak, Andriel Gustavo ; Marques, Ana Letícia Rodrigues ; Meznerovvicz, Ademar Francisco Fagundes ; Marangoni, Marina ; Braz, Paulo Henrique ; Lemes, Mel Takazono ; Belluci, Marius da Silva Pinto

The South American coati (Nasua nasua) is increasingly affected by anthropogenic pressures, making safe handling and physiological monitoring essential for conservation programs. This study aimed to characterize electrocardiographic (ECG) parameters in anesthetized free-ranging coatis and establish preliminary reference values. Ten female coatis (3 kits, 4 juveniles, 3 adults) were captured in Iguaçu National Park, Brazil, and chemically immobilized with intramuscular tiletamine-zolazepam (7 mg/kg). ECG recordings were obtained 30 min post-administration using standard bipolar and unipolar limb leads. Parameters measured included P and T wave amplitudes and durations, QRS complex, PR interval (PRi), QT interval (QTi), RR interval (RRi), ST segment, and mean electrical axes. Heart rate variability (HRV) was assessed using time-domain and nonlinear methods. All coatis exhibited normal sinus rhythm with well-defined ECG waveforms. PRi values (0.062 ± 0.005 s) were concordant with predicted allometric values (p = 0.083), indicating appropriate atrioventricular conduction. QRS morphology and mean electrical axis (71°-156°). No significant differences in ECG or HRV parameters were observed across age groups, indicating stable cardiac electrical activity and autonomic regulation. This study provides the first detailed ECG description for anesthetized coatis, expanding knowledge of their cardiac physiology. The reference values can inform clinical monitoring, field procedures, and conservation interventions.

2026-03-01·VETERINARY ANAESTHESIA AND ANALGESIA

General anaesthesia in non-human great apes: a scoping review

Review

作者: White, Kate ; Brennan, Marnie L ; Liptovszky, Matyas

OBJECTIVE:

To identify anaesthesia-related risk between common domestic species and humans by analysing peer-reviewed and other literature on anaesthesia in great apes in both human care and free-ranging settings and thereby to identify knowledge gaps.

DATABASES USED:

We conducted literature searches in the CAB Abstracts, MEDLINE and Zoological Record databases, as well as conference proceedings of the American Association of Zoo Veterinarians, the British Veterinary Zoological Society and the European Association of Zoo and Wildlife Veterinarians.

RESULTS:

Of the 142 studies reviewed, 51 were conference abstracts and 91 were peer-reviewed journal articles. There was a steady increase in the number of published papers since 1960, surpassing 30 papers per decade since 2000. Case studies and series made up 79% of included studies, and 91-94% for all species except chimpanzees. Although data for chimpanzees appeared extensive, data for bonobos, eastern gorillas, and Sumatran orangutans were notably lacking. Infant great ape anaesthesia and anaesthesia in free-ranging settings were underrepresented in the literature. Over 50 anaesthetic drugs were reported in the literature, with ketamine, tiletamine/zolazepam, midazolam, medetomidine and isoflurane being most frequently reported. There is a notable lack of reporting of anaesthesia-related adverse events (AEs), and many studies failed to report key details, which limits reproducibility. Respiratory and cardiovascular AEs were reported most frequently. The incidence of prolonged recoveries and excitation on recovery was higher than in other domestic species, and there was a notable lack of hypothermia reported as an AEs.

CONCLUSIONS AND CLINICAL RELEVANCE:

This is the first evidence synthesis on general anaesthesia in great apes, and findings highlight the need for targeted research on underrepresented species and improved reporting of anaesthesia practices and AEs.

2025-12-03·AMERICAN JOURNAL OF VETERINARY RESEARCH

Vatinoxan reduces hypertension and bradycardia without compromising anesthesia quality in medetomidine-anesthetized white-tailed deer: a randomized trial

Article

作者: D'Angelo, Gino J. ; Williams, Jarred M. ; Barletta, Michele ; Gremling, Megan M. ; Camlic, Sarah ; Sallaberry-Pincheira, Nicole ; Divers, Stephen J.

Abstract:

Objective:

To evaluate whether adding vatinoxan to an α 2 -adrenoceptor agonist–based anesthetic protocol would attenuate cardiovascular depression or influence anesthetic depth in white-tailed deer ( Odocoileus virginianus ) anesthetized with medetomidine and tiletamine/zolazepam.

Methods:

In a masked crossover design, 9 healthy adult female white-tailed deer were anesthetized from February 24 through March 14, 2025, with IM medetomidine (0.075 mg/kg) and tiletamine/zolazepam (4 mg/kg). Once anesthetized and monitored, each deer received either IM vatinoxan (1.5 mg/kg) or an equivalent volume of saline solution. Subjects were monitored for 45 minutes after treatment administration, after which anesthesia was reversed with IM atipamezole (0.35 mg/kg). Vital signs, serial arterial blood gas values, sedation score, and recovery scores were analyzed for significant differences.

Results:

Vatinoxan administration resulted in significantly higher heart rates and lower mean arterial pressure, rectal temperature, and PaCO 2 . Hypotension was noted in 1 animal following vatinoxan administration. No significant differences were found in oxygen saturation, sedation scores, recovery times, or the total amount of additional anesthetic supplementation required.

Conclusions:

Vatinoxan provided cardiac-sparing effects in white-tailed deer without compromising anesthetic depth. Further studies are warranted to investigate its impact on tissue perfusion in the absence of oxygen supplementation and to determine the minimum effective dose in this setting.

Clinical Relevance:

Vatinoxan, administered IM at 20 times the medetomidine dose, may be considered as an adjunct to medetomidine-tiletamine-zolazepam anesthetic protocols for short procedures to mitigate peripheral vasoconstriction and bradycardia.

100 项与唑拉西泮相关的药物交易

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