预约演示
更新于：2025-12-15
Phloroglucin
间苯三酚
更新于：2025-12-15
概要
基本信息
非在研机构 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期- |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C6H6O3 |
InChIKeyQCDYQQDYXPDABM-UHFFFAOYSA-N |
CAS号108-73-6 |
关联
38
项与 间苯三酚 相关的临床试验CTR20252298
间苯三酚口崩片在中国健康人群中空腹和餐后状态下单次给药的人体生物等效性临床试验
ChiCTR2500104563
Efficacy of phloroglucinol and diclofenac sodium on pain relief for renal colic due to ureteral stone: a single-center, prospective, randomized trial
CTR20250614
间苯三酚口崩片（80mg）在中国健康受试者中空腹和餐后给药条件下随机、开放、两制剂、交叉生物等效性研究
100 项与 间苯三酚 相关的临床结果
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100 项与 间苯三酚 相关的转化医学
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100 项与 间苯三酚 相关的专利（医药）
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5,634
项与 间苯三酚 相关的文献（医药）2026-01-01European Journal of Obstetrics & Gynecology and Reproductive Biology
Effectiveness and safety of phloroglucinol combined with oxytocin intravenous drip in delivery women: a systematic review and meta-analysis
Review
作者: He, Yubing ; Zhao, Linjia ; Gong, Ying
OBJECTIVE:
Oxytocin is the first-line uterotonic agent for labor induction and augmentation, but high-dose or prolonged use is often associated with adverse effects. Phloroglucinol, an antispasmodic, may alleviate cervical spasm and promote dilation. While existing randomized controlled trials (RCTs) suggest that combining phloroglucinol with oxytocin may shorten labor duration safely, a comprehensive meta-analysis is lacking. This study aimed to evaluate the efficacy and safety of intravenous phloroglucinol combined with oxytocin in term parturients to provide evidence-based guidance for clinical practice.
METHODS:
This systematic review was registered in PROSPERO (CRD420251143546). A systematic search was conducted of PubMed, Embase, Scopus, CNKI, Wanfang, and VIP databases from inception to July 2025. A total of 20 RCTs involving 2,819 parturients were included. Primary outcomes included total labor duration, first-stage labor duration, neonatal Apgar score, rate of normal vaginal delivery (NVD), Bishop score, degree of cervical dilation, and maternal-neonatal safety outcomes (fetal distress, postpartum hemorrhage, neonatal asphyxia, uterine atony, cervical laceration, and cervical edema). Meta-analysis was performed using Stata 18.0. A fixed-effects model was applied when I2 < 50 %, and a random-effects model was used when I2 ≥ 50 %. Subgroup and sensitivity analyses were conducted for outcomes with high heterogeneity. Publication bias was assessed for outcomes reported in more than seven studies.
RESULTS:
Compared to oxytocin alone, combination therapy significantly reduced total labor duration (MD = -3.05, 95 % CI [-3.91, -2.18], P < 0.001) and first-stage labor duration (MD = -3.08, 95 % CI [-3.96, -2.20], P < 0.001).The combination therapy did not significantly affectApgar scores (SMD = -0.08, 95 % CI [-0.02, 0.18], P = 0.12) but increased the rate of normal vaginal delivery (NVD) (OR = 1.10, 95 % CI [1.02, 1.18], P = 0.01). Safety analysis showed that combination therapywas associated withreduced risks of fetal distress (OR = 0.42, 95 % CI [0.25, 0.90], P = 0.02), postpartum hemorrhage (OR = 0.27, 95 % CI [0.12, 0.59], P < 0.01), neonatal asphyxia (OR = 0.47, 95 % CI [0.25, 0.90], P = 0.02), uterine atony (OR = 0.46, 95 % CI [0.22, 0.94], P = 0.03), cervical laceration (OR = 0.17, 95 % CI [0.03, 0.92], P = 0.04), and cervical edema (OR = 0.25, 95 % CI [0.06, 0.98], P = 0.05). Most outcomes exhibited low heterogeneity (I2 < 50 %), and sensitivity analysisconfirmed the robustness of the findings.
CONCLUSION:
Intravenous administration of phloroglucinol combined with oxytocin in term parturients significantly accelerates labor progression and increases the rate of vaginal delivery without increasing adverse maternal or neonatal events. This strategy appears to beasafe and effectiveapproachfor labor management. Further validation through large-scale, multicenter RCTs is recommended.
2025-12-01INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Multifunctional carbon dots in hydroxyethyl cellulose/polyvinyl alcohol intelligent active film for food quality maintenance and freshness monitoring
Article
作者: Feng, Zhibiao ; Qin, Shuaifan ; Zhang, Huaijie ; Liu, Siyuan ; Pang, Mingyao ; Tian, Bo ; Chen, Yongshi
This study presents the development of multifunctional carbon dots (RCDs) by integrating neutral red with o-phenylenediamine and phloroglucinol, endowing the RCDs with antioxidant, antibacterial, and dual-mode pH-responsive properties. A composite matrix was subsequently fabricated by combining hydroxyethyl cellulose (HEC), valued for its film-forming ability and biodegradability, with polyvinyl alcohol (PVA), which imparted mechanical resilience. To overcome the functional limitations of conventional packaging, RCDs were incorporated into the HEC/PVA matrix, enabling the films to provide both active preservation and intelligent monitoring. SEM and FTIR analyses confirmed that the incorporated RCDs promoted a dense, cross-linked network. This network improved the film's UV-blocking performance, water vapor barrier properties, and tensile strength. The HP/RCDs films exhibited significant radical scavenging activity, with rates of 74.46 % for DPPH and 67.07 % for ABTS, as well as strong antibacterial properties, inhibiting all bacteria by more than 70 %. Additionally, the films retained the pH-responsiveness characteristic of RCDs. In practical applications, the HP/RCDs-3 film extended the shelf life of grapes by 2 days at 4 °C, accompanied by a visible color change from yellow to reddish-brown. It also prolonged the freshness of pork and salmon by 18 h and 10 h at 25 °C, respectively. These results demonstrate that the developed CDs-based intelligent active packaging system has significant potential for both practical food preservation and real-time freshness monitoring.
2025-11-18ACS Omega
Extraction of Phenolic Compounds with the Highly Efficient Novel Coextractants Cyclohexanone and Methyl Isobutyl Ketone
Article
作者: Liu, Tiankun ; Yang, Gary Q. ; Cai, Weibin ; Sun, Liangxia ; Wang, Yujun
Extractant selection is the most important aspect for the extraction treatment of phenolic wastewater from the coal chemical industry. Highly efficient extractants are urgently needed. To our knowledge, we identified for the first time one set of coextractants, cyclohexanone and methyl isobutyl ketone (MIBK), after spending plenty of time and energy for the extraction of phenolic compounds, including polyhydroxyphenol, from wastewater. Fourier transform infrared (FTIR) spectroscopy of the solvents before and after extraction shows that intermolecular hydrogen bonding between the molecules of the extractants and phenols is established, contributing to the high performance. The effects of pH, temperature, and salt concentration on the extractant performance were then studied. The extraction favors acidic and neutral pH values. Increasing the temperature has a negative influence on the extraction. The salt effect by putting inorganic salt can obviously enhance the extractant performance. Compared with single extractants such as MIBK and diisopropyl ether (DIPE), coextractants have significantly improved recovery rates of resorcinol and phloroglucinol. To learn if this set of coextractants also has good performance in practical extraction processes for the treatment of industrial wastewater, three-stage countercurrent extraction experiments were carried out with these coextractants for the extraction of phenolic compounds from coal chemical wastewater. Cascade experiments were used to simulate and verify the countercurrent extraction process in actual industry. According to the results, it is observed that this set of coextractants also has good performance in practical extraction processes for the treatment of industrial wastewater.
100 项与 间苯三酚 相关的药物交易
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 肌肉痉挛 | 中国 | - |
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 腹泻型肠易激综合征 | 临床2期 | 美国 | 2023-12-28 | |
| 肝细胞癌 | 临床前 | 韩国 | 2025-06-13 |
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