This phase III study is designed as a double blind, randomized, multi-nation, multi-center, placebo controlled clinical research, which aims to evaluate the safety and efficacy of Dantonic® (T89) in patients with chronic stable angina pectoris.

开始日期2012-08-01

申办/合作机构

Tasly Pharmaceuticals, Inc.

100 项与三七提取物和冰片相关的临床结果

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100 项与三七提取物和冰片相关的转化医学

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100 项与三七提取物和冰片相关的专利（医药）

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项与三七提取物和冰片相关的文献（医药）

2017-04-01·Journal of Ethnopharmacology2区 · 医学

Effects of Panax notoginseng ginsenoside Rb1 on abnormal hippocampal microenvironment in rats

2区 · 医学

Article

作者: Li, Shude ; Li, Chen ; Pu, Lijin ; Luo, Yaohui ; Luo, Haiyun ; Guo, Ying ; Wu, Lanou ; Wang, Shiyun ; An, Dong ; Li, Minghong ; Zhou, Xin-Fu

Cerebral ischemia damages central neurons, and abnormal microenvironment in ischemic condition is the key factor to the damages. The increase of local concentration of glutamic acid, the overload of Ca²⁺, and the mitochondrial stress caused by release of cytochrome C are important factors of abnormal microenvironment in cerebral ischemia. In this study ginsenoside Rb1, a compound from Panax Notoginseng, was used to intervene abnormal environment of neurons in the hippocampal CA1 region in two animal models (microperfusion model and photothrombosis model).RESULTSCompared with the vehicle in the sham group, ginsenoside had following effects. a) ginsenoside Rb1 increased the regional cerebral blood flow (rCBF) and the stability of neuronal ultrastructure in in the hippocampal CA1 region and improved the adaptability of neurons in two models. b) ginsenoside Rb1 improved the expression level of glial glutamate transporter1 (GLT-1) and reversed the uptake of glutamate (Glu) after ischemia, and as a result thereby decreased the excitability of Glu and the expression level of GLT-1 was proportional to the dose of ginsenoside Rb1 and similar to that of Nimodipine. c) ginsenoside Rb1 inhibited the expression level of NMDAR and the overload of Ca²⁺, thereby reducing neuronal damages. Meanwhile, the expression level of NMDAR was inversely proportional to the dose of ginsenoside Rb1, which was similar to that of Nimodipine. d) ginsenoside Rb1 decreased the release of cytochrome C (Cyt-C) and reduced the damages caused by neuronal mitochondrial stress. Meanwhile, the release of Cyt-C was inversely proportional to the dose of ginsenoside Rb1, which was similar to that of Nimodipine. Ginsenoside Rb1 may be as an effective drug for neuroprotection and improve cerebral blood flow after acute ischemia and prevent the secondary brain damage induced by stroke.

2013-01-01·Journal of Analytical Methods in Chemistry4区 · 化学

Effects of Borneol on Pharmacokinetics and Tissue Distribution of Notoginsenoside R1 and Ginsenosides Rg1 and Re inPanax notoginsengin Rabbits

4区 · 化学

ArticleOA

作者: Feng, Weiyi ; Zhao, Xinfeng ; Liu, Qinshe ; Zhao, Ming ; Wang, Shixiang ; He, Xi ; Zang, Weijin ; Zheng, Xiaohui

The purpose of this study is to investigate the effects of Borneol on the pharmacokinetics of notoginsenoside R1 (NGR1) and the ginsenosides Rg1 (GRg1) and Re (GRe) inPanax notoginseng. Reversed phase high-performance liquid chromatography coupled with electrospray ion trap mass spectrometry was employed to determine the concentrations of the three compounds in rabbit plasma. In comparison with rabbits administratedPanax notoginsengextract alone, animals simultaneously takingPanax notoginsengextract and Borneol exhibited significant differences in pharmacokinetic parameters of NGR1, GRg1, and GRe, such as increasing their bioavailability. Quantities of NGR1, GRg1, and GRe in rabbit tissues were also increased after combining administration of Borneol. In addition, the apparent permeability coefficients (Papp) of NGR1, GRg1, and GRe were raised by Borneol significantly in Caco-2 cells. However, no significant changes were observed in the efflux ratio (Er) of NGR1, GRg1 and GRe. These data indicate that Borneol has the properties of enhancing the intestinal absorption, increasing the distribution, and inhibiting the metabolism of NGR1, GRg1, and GRe. The underlying mechanism might be attributed to the loosening of the intercellular tight junction.

100 项与三七提取物和冰片相关的药物交易

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