2023-08-04·Respiration; international review of thoracic diseases
Long-Term Safety, Outcome, and Clinical Effects of Subcutaneous and Intravenous Treprostinil Treatment in Patients with Severe Chronic Pulmonary Arterial Hypertension.
作者: Satenik Harutyunova ; Nicola Benjamin ; Christina Eichstaedt ; Alberto M Marra ; Panagiota Xanthouli ; Christian Nagel ; Ekkehard Grünig ; Benjamin Egenlauf
Current guidelines recommend treatment with parenteral prostacyclin analogs in patients with severe pulmonary arterial hypertension (PAH), who have insufficient response to treatment. Real-life data are sought to help physicians in treatment decisions and clinical care of patients.
This study analyzed safety, clinical effects, and long-term outcomes of subcutaneous (sc) and/or intravenous (iv) treprostinil via different pump systems in consecutive patients with PAH.
Thirty-seven patients with severe progressive PAH despite dual combination therapy (20 female, mean age: 52.3 ± 15 years, mean pulmonary vascular resistance: 12.1 ± 5.1 WU) were initiated with add-on treprostinil sc and were routinely clinically assessed. Changes in clinical parameters, adverse events, and outcome were analyzed retrospectively.
In 24 of 37 patients, treprostinil administration was continued iv via implantation of LENUS Pro® pump after 3 ± 1.3 months, 6 patients continued with sc therapy, and 7 discontinued treatment. After 3, 6, 9, and 12 months of treprostinil treatment, patients showed a significant improvement in mean 6-min walk distance and tricuspid annular plane systolic excursion compared to baseline. In 8 of the 24 patients, iv pumps required surgical revision. During a mean follow-up of 2.82 ± 1.95 years, 12 patients died, four received lung transplantation. Transplant-free survival after 1, 2, and 3 years was 85.7%, 69.2%, and 65.3%, respectively.
sc treprostinil as add-on to double combination treatment significantly improved exercise capacity and right heart function. In most patients, treprostinil could be continued via more tolerable iv administration approach (LENUS Pro® pump), showing reasonable overall survival with respect to the severity of PAH.
2023-08-03·Acta bio-medica : Atenei Parmensis
Real life use of prostacyclin analog (iloprost), a multi-centric survey data from the Scleroderma study group Emilia Romagna (Sclero-RER) and review of the literature.
作者: Luca Magnani ; Alarico Ariani ; Andrea Lo Monaco ; Francesco Girelli ; Amelia Spinella ; Federica Lumetti ; Massimo Reta ; Eugenio Arrigoni ; Francesco Ursini ; Alessandra Bezzi ; Pierluigi Cataleta ; Luca Montaguti ; Marica Trevisani ; Matteo Colina ; Simone Bernardi ; Marco De Pinto ; Giorgio Galoppini ; Sofia Testoni ; Andrea Becciolini ; Francesca Pignataro ; Jacopo Ciaffi ; Elena Bravi ; Mariacristina Focherini ; Sheila Moscatelli ; Paola Sambo ; Marco Fusconi ; Stefania Corvaglia ; Gianluigi Bajocchi ; Daniele Conti ; Carlo Salvarani ; Dilia Giuggioli
BACKGROUND AND AIM:
Iloprost is recommend worldwide for the treatment of RP and the healing of DUs. The aim of this study is to report the regimens of Iloprost administered in different rheumatological centers within the same regional Health System Methods: A questionnaire exploring different items related to the use of Iloprost was developed and reviewed by three expert rheumatologists. The questionnaire was distributed as an online survey to all local SSc referral centers in Emilia-Romagna (Italy). Data are reported as percentage or median with interquartile range (IQR), as appropriate. An updated review of world literature on this topic was also carried out.
All the invited centers completed the survey. There were both local (8) and university hospitals (4). The majority (58%) had a rheumatologist as head physician. All centers used Iloprost: a single monthly administration was the most common treatment (75%). The cycle lasted 1 [IQR 1-2] days with a 0.5-2.0 ng/Kg/min dose according to the drug tolerance of the patients. There were overall 68 spots (beds, reclining armchair, or simple armchair); 2.0 [1.5-4.0] patients were able to receive Iloprost at the same time. University Hospitals had more physicians at their disposal than local hospitals but less paramedic personnel (respectively: 1.8 vs 1.2 physicians, 1.5 vs 2.1 nurses).
These observations were in line with the majority of previous studies reporting different regimens, comparing similar (but not identical) dose and schedule administration, however, despite differences being at times substantial, no standard infusion method is yet available.
2023-07-29·International journal of molecular sciences
Treprostinil Reconstitutes Mitochondrial Organisation and Structure in Idiopathic Pulmonary Fibrosis Cells.
作者: Lei Fang ; Wei-Chih Chen ; Peter Jaksch ; Antonio Molino ; Alessandro Saglia ; Michael Roth ; Christopher Lambers
Idiopathic pulmonary fibrosis (IPF) presents as an incurable change in the lung tissue and mitochondrial dysfunction of unknown origin. Treprostinil, a prostacyclin analogue, has been suggested for IPF therapy. This study assessed the effect of treprostinil on the cAMP signalling and mitochondrial activity in healthy lung fibroblasts and fibroblast-like cells from IPF patients. Six control fibroblast strains and six fibroblast-like IPF cell strains were isolated and expanded from freshly resected lung tissue. The cells were grown to confluence before being treated with either transforming growth factor (TGF)-β1, treprostinil, their combination, or a vehicle for up to 2 days. Mitochondria-regulating proteins were analysed using Western blotting and immunofluorescence, and the mitochondria were analysed using cytochrome C, mitochondrial cytochrome C oxidase II (MTCO2), and MTCO4. The IPF cells showed an increased rate of damaged mitochondria, which were significantly reduced when the cells were treated with treprostinil over 24 h. In the control cells, treprostinil prevented TGF-β-induced mitochondrial damage. Treatment with treprostinil modified the expression of several mitochondria-regulating proteins. In both cell types, treprostinil upregulated the expression of PTEN, p21(Waf1/Cip1), beclin1, LC3 II, parkin, PINK1, MTCO2, and MTCO4. In contrast, treprostinil downregulated the phosphorylation of mTOR and the expression of p62, mitofusin1, and mtiofusin2 in IPF cells. This might explain the reduced mitochondrial damage observed in treprostinil-treated IPF cells and suggest an improvement in the mitochondrial function in IPF. In this study, treprostinil improved mitochondrial impairment in vitro, which might, in part, explain the beneficial clinical effects documented in patients.
Results from the EXPEDITE study of Remodulin® induction prior to Orenitram® therapy to be presented at ATS
Baseline patient data from the TETON studies of Tyvaso® Inhalation Solution in patients with idiopathic pulmonary fibrosis to be presented at ATS
ATS presentation examines geographical barriers as a social determinant of health for PAH patients; demonstrates UT’s commitment to reducing barriers to PAH care
Data on United Therapeutics’ xenotransplantation and ex-vivo lung perfusion efforts to be presented at ISHLT
At ATS, United Therapeutics is hosting a sponsored symposium on PH-ILD and is sponsoring the ATS 2023 Women’s Forum
SILVER SPRING, Md. & RESEARCH TRIANGLE PARK, N.C.--(BUSINESS WIRE)-- United Therapeutics Corporation (Nasdaq: UTHR), a public benefit corporation, today announced that recent research across its development portfolio will be presented at the International Society for Heart and Lung Transplantation (ISHLT) 43rd Annual Meeting and Scientific Sessions in Denver, Colorado on April 19-22, 2023, and at the American Thoracic Society (ATS) International Conference in Washington, D.C. on May 19-24, 2023. At ATS, United Therapeutics will host an educational symposium on pulmonary hypertension associated with interstitial lung disease (PH-ILD) and is sponsoring the ATS 2023 Women’s Forum.
“Our posters and presentations at ISHLT 2023 will provide additional insight into outcomes associated with our ex-vivo lung perfusion program and initial detail into recent xenotransplant work in human preclinical models using our UHeart™ xenoheart,” noted Gil Golden, M.D., Ph.D., Chief Medical Officer at United Therapeutics. “In addition, we’re excited to present an overview of the phase 4 ARTISAN study that seeks to investigate a novel targeted treatment approach, aimed at the reduction of pathologically high mean pulmonary artery pressures through early and rapid parenteral treprostinil up-titration, potentially leading to improved right ventricular structure and function in patients with pulmonary arterial hypertension.”
“Following top line data last year, we’re looking forward to presenting additional data from the EXPEDITE study that demonstrated a short induction period with Remodulin could lead to more rapidly achieving an efficacious dose of Orenitram, as well as baseline data from the TETON studies of nebulized Tyvaso in patients with idiopathic pulmonary fibrosis,” said Andrew Nelsen, PharmD, Vice President, Global Medical Affairs at United Therapeutics. “We are also looking forward to presenting data from ongoing research into the often-overlooked geographic differences in access to care among PAH patients in the U.S.”
ISHLT posters and presentations include:
Poster Session 2. Cardiology, Thursday, April 20, 4:15 - 5:15 PM MT: THU-144 851 – ARTISAN: A Novel Study of Mean Pulmonary Artery Pressure-Targeted Approach with Early and Rapid Treprostinil Therapy to Reverse Right Ventricular Remodeling in Pulmonary Arterial Hypertension. Presented by Raymond Benza, The Ohio State University.
Poster Session 3. Pulmonology, Friday, April 21, 5:00 - 6:00 PM MT: FRI-217 1233 – Utilization and Outcomes with Single Lung Transplantation Following Ex Vivo Lung Perfusion Using a Centralized Lung Evaluation System at a Dedicated Facility. Presented by Jorge Mallea, Mayo Clinic Florida.
Poster Session 3. Pulmonology, Friday, April 21, 5:00 - 6:00 PM MT: FRI-218 1234 – Comparison of Lung Utilization from NRP-DCD vs Non-NRP DCD Using EVLP. Presented by Sean Francois, Vanderbilt University Medical Center.
Session 93. A MIDSUMMER NIGHT'S DREAM: From Mitochondria to Xenotransplantation: Novel Research Coming to You!, Saturday, April 22, 11:45 - 11:55 AM MT: 203 – Two 10-Gene Modified Xenoheart Transplants into Brain Dead Decedents. Presented by Nader Moazami, NYU Langone Health.
Plenary 3. General Session III, Saturday, April 22, 9:50 - 10:15 AM MT: Xenotransplantation: The Future is Now. Presented by Robert Montgomery, NYU Langone Transplant Institute.
ATS posters and presentations include:
Mini Symposium, Monday May 22, 3:51 - 4:03 AM ET: B97 – Remodulin Induction Facilitates Rapid Achievement of Therapeutic Doses of Oral Treprostinil: Results from the EXPEDITE Study. Presented by John Kingrey, Integris Baptist Medical Center.
Rapid abstract poster discussion session, Sunday, May 21, 9:00 - 11:00 AM ET: A22/304 – Understanding Differences in Geographic Access to Care Among Patients Treated for Pulmonary Arterial Hypertension in the United States. Presented by Natalie West, United Therapeutics.
Thematic poster session, Sunday, May 21, 11:30 - 1:15 PM ET: A59/P766 – Preliminary Baseline Data from the TETON Phase 3 Clinical Trials of Inhaled Treprostinil in the Treatment of Idiopathic Pulmonary Fibrosis. Presented by Steven Nathan, INOVA Fairfax Hospital.
Thematic poster session, Monday, May 22, 11:30 - 1:15 PM ET: B57/P161 – Win Ratio Analysis of the FREEDOM-EV Trial - A Hierarchical Approach to Multiple Clinical Endpoints. Presented by James White, University of Rochester Medical Center.
Thematic poster session, Monday, May 22, 11:30 - 1:15 PM ET: B57/P168 – Assessing the Correlation Between Actigraphy Data and Clinical Measures: Insights From The ADAPT Registry. Presented by James Gagermeier, Loyola University Medical Center.
Thematic poster session, Monday, May 22, 11:30 - 1:15 PM ET: B57/P175 – Correlation of WHO Functional Class and Patient-Reported Outcome Measures in Adults with Pulmonary Arterial Hypertension. Presented by Karim El-Kersh, University of Nebraska Medical Center.
Thematic poster session, Monday, May 22, 11:30 - 1:15 PM ET: B59/P209 – Study Design of the Decentralized EVOLVE Study Evaluating Real-world Use of Next Generation Infusion Pumps to Deliver Parenteral Treprostinil in Patients with Pulmonary Arterial Hypertension. Presented by Margo Sketch, United Therapeutics.
Thematic poster session, Monday, May 22, 11:30 - 1:15 PM ET: B59/P215 – Dose-response Analyses of Treprostinil Inhalation Powder in PAH and Its Effect on 6MWD. Presented by Karim El-Kersh, University of Nebraska Medical Center.
Thematic poster session, Tuesday, May 23, 11:30 - 1:15 PM ET: C36/P898 – The PAH Patient Perspective: Factors Influencing Treatment Initiation with Inhaled Prostacyclin Therapy. Presented by Karim El-Kersh, University of Nebraska Medical Center.
Poster discussion session, Wednesday, May 24, 8:00 - 10:00 AM ET: D28/501 – A Novel Approach to Clinical Change Endpoints: A Win Ratio Analysis of the INCREASE Trial. Presented by Steven Nathan, INOVA Fairfax Hospital.
Poster discussion session, Wednesday, May 24, 8:00 - 10:00 AM ET: D28/505 – The Safety and Efficacy of Inhaled Treprostinil in Patients with PH-ILD on Supplemental Oxygen: A Post-hoc Analysis of the INCREASE Study. Presented by Sandeep Sahay, Houston Methodist Hospital.
Sponsored events at ATS include:
PH-ILD Reimagined: 2023 Updates in Disease State, Treatment, and Device Options, Sunday, May 21, 5:30 PM ET, featuring Jamie Rutland, West Coast Lung, Rutland Medical Group; Steven Nathan, INOVA Fairfax Hospital; and Colleen McEvoy, Washington University Physicians. The symposium will be held at the Renaissance Hotel Washington, DC Downtown, Potomac Ballroom, Salon 1-3.
The ATS 2023 Women’s Forum, Monday, May 27, 11:45 AM - 1:15 PM ET, featuring Refiloe, University of KwaZulu Natal, and Mina Gaga, Imperial College and the Royal Brompton Hospital.
About Orenitram® (treprostinil) Extended-Release Tablets
Orenitram is a prostacyclin mimetic indicated for treatment of pulmonary arterial hypertension (PAH) (WHO Group 1) to delay disease progression and to improve exercise capacity. The studies that established effectiveness included predominately patients with WHO functional class II-III symptoms and etiologies of idiopathic or heritable PAH (66%) or PAH associated with connective tissue disease (26%).
Important Safety Information for Orenitram
Avoid use of Orenitram in patients with severe hepatic impairment (Child Pugh Class C) due to increases in systemic exposure.
Warnings and Precautions
Abrupt discontinuation or sudden large reductions in dosage of Orenitram may result in worsening of PAH symptoms.
The Orenitram tablet shell does not dissolve. In patients with diverticulosis, Orenitram tablets can lodge in a diverticulum.
In the 12-week, placebo-controlled, monotherapy study, and an event-driven, placebo-controlled, combination therapy study, adverse reactions that occurred at rates at least 5% higher on Orenitram than on placebo included headache, diarrhea, nausea, vomiting, flushing, pain in jaw, pain in extremity, hypokalemia, abdominal discomfort, and upper abdominal pain.
Co-administration of Orenitram and the CYP2C8 enzyme inhibitor gemfibrozil increases exposure to treprostinil; therefore, Orenitram dosage reduction may be necessary in these patients.
Animal reproductive studies with Orenitram have shown an adverse effect on the fetus. There are no adequate and well-controlled studies with Orenitram in pregnant women.
It is not known whether treprostinil is excreted in human milk or if it affects the breastfed infant or milk production.
Safety and effectiveness of Orenitram in pediatric patients have not been established.
Use of Orenitram in patients aged 65 years and over demonstrated slightly higher absolute and relative adverse event rates compared to younger patients. Caution should be used when selecting a dose for geriatric patients.
There is a marked increase in the systemic exposure to treprostinil in hepatically impaired patients.
Please see Full Prescribing Information and Patient Information at or call 1-877-UNITHER (1-877-864-8437).
About Remodulin® (treprostinil) Injection
Remodulin is a prostacyclin vasodilator indicated for the treatment of pulmonary arterial hypertension (PAH; WHO Group 1) to diminish symptoms associated with exercise. Studies establishing effectiveness included patients with NYHA Functional Class II-IV symptoms and etiologies of idiopathic or heritable PAH (58%), PAH associated with congenital systemic-to-pulmonary shunts (23%), or PAH associated with connective tissue diseases (19%).
In patients with PAH requiring transition from epoprostenol, Remodulin is indicated to diminish the rate of clinical deterioration. Consider the risks and benefits of each drug prior to transition.
Important Safety Information for Remodulin
Warnings and Precautions
Chronic intravenous (IV) infusions of Remodulin delivered using an external infusion pump with an indwelling central venous catheter are associated with the risk of blood stream infections (BSIs) and sepsis, which may be fatal. Therefore, continuous subcutaneous (SC) infusion is the preferred mode of administration.
Avoid abrupt withdrawal or sudden large reductions in dosage of Remodulin, which may result in worsening of PAH symptoms.
Titrate slowly in patients with hepatic or renal insufficiency, because such patients will likely be exposed to greater systemic concentrations relative to patients with normal hepatic or renal function.
Remodulin is a pulmonary and systemic vasodilator. In patients with low systemic arterial pressure, treatment with Remodulin may produce symptomatic hypotension.
Remodulin inhibits platelet aggregation and increases the risk of bleeding.
In clinical studies of SC Remodulin infusion, the most common adverse events reported were infusion site pain and infusion site reaction (redness, swelling, and rash). These symptoms were sometimes severe and sometimes required treatment with narcotics or discontinuation of Remodulin. The IV infusion of Remodulin with an external infusion pump has been associated with a risk of blood stream infections, arm swelling, paresthesias, hematoma, and pain. Other common adverse events (≥3% more than placebo) seen with either SC or IV Remodulin were headache (27% vs. 23%), diarrhea (25% vs. 16%), nausea (22% vs. 18%), rash (14% vs. 11%), jaw pain (13% vs. 5%), vasodilatation (11% vs. 5%), edema (9% vs. 3%), and hypotension (4% vs. 2%).
Remodulin dosage adjustment may be necessary if inhibitors or inducers of CYP2C8 are added or withdrawn.
In patients with mild or moderate hepatic insufficiency, decrease the initial dose of Remodulin to 0.625 ng/kg/min of ideal body weight, and monitor closely. Remodulin has not been studied in patients with severe hepatic insufficiency.
Safety and effectiveness of Remodulin in pediatric patients have not been established.
It is unknown if geriatric patients respond differently than younger patients. Caution should be used when selecting a dose for geriatric patients.
There are no adequate and well-controlled studies with Remodulin in pregnant women. It is not known whether treprostinil is excreted in human milk or if it affects the breastfed infant or milk production.
Please see accompanying Full Prescribing Information for Remodulin.
For additional information, visit or call Customer Service at 1-877-UNITHER (1-877-864-8437).
About TYVASO® (treprostinil) Inhalation Solution and TYVASO DPI® (treprostinil) Inhalation Powder
TYVASO (treprostinil) Inhalation Solution and TYVASO DPI (treprostinil) Inhalation Powder are prostacyclin mimetics indicated for the treatment of:
Pulmonary arterial hypertension (PAH; WHO Group 1) to improve exercise ability. Studies with TYVASO establishing effectiveness predominately included patients with NYHA Functional Class III symptoms and etiologies of idiopathic or heritable PAH (56%) or PAH associated with connective tissue diseases (33%).
The effects diminish over the minimum recommended dosing interval of 4 hours; treatment timing can be adjusted for planned activities.
While there are long-term data on use of treprostinil by other routes of administration, nearly all clinical experience with inhaled treprostinil has been on a background of an endothelin receptor antagonist (ERA) and/or a phosphodiesterase type 5 (PDE-5) inhibitor. The controlled clinical experience with TYVASO was limited to 12 weeks in duration.
Pulmonary hypertension associated with interstitial lung disease (PH-ILD; WHO Group 3) to improve exercise ability. The study with TYVASO establishing effectiveness predominately included patients with etiologies of idiopathic interstitial pneumonia (IIP) (45%) inclusive of idiopathic pulmonary fibrosis (IPF), combined pulmonary fibrosis and emphysema (CPFE) (25%), and WHO Group 3 connective tissue disease (22%).
IMPORTANT SAFETY INFORMATION
WARNINGS AND PRECAUTIONS
TYVASO and TYVASO DPI are pulmonary and systemic vasodilators. In patients with low systemic arterial pressure, either product may produce symptomatic hypotension.
Both products inhibit platelet aggregation and increase the risk of bleeding.
Co-administration of a cytochrome P450 (CYP) 2C8 enzyme inhibitor (e.g., gemfibrozil) may increase exposure (both Cmax and AUC) to treprostinil. Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. Increased exposure is likely to increase adverse events associated with treprostinil administration, whereas decreased exposure is likely to reduce clinical effectiveness.
Like other inhaled prostaglandins, TYVASO and TYVASO DPI may cause acute bronchospasm. Patients with asthma or chronic obstructive pulmonary disease (COPD), or other bronchial hyperreactivity, are at increased risk for bronchospasm. Ensure that such patients are treated optimally for reactive airway disease prior to and during treatment with TYVASO and TYVASO DPI.
DRUG INTERACTIONS/SPECIFIC POPULATIONS
The concomitant use of either product with diuretics, antihypertensives, or other vasodilators may increase the risk of symptomatic hypotension.
Human pharmacokinetic studies with an oral formulation of treprostinil (treprostinil diolamine) indicated that co-administration of the cytochrome P450 (CYP) 2C8 enzyme inhibitor, gemfibrozil, increases exposure (both Cmax and AUC) to treprostinil. Co-administration of the CYP2C8 enzyme inducer, rifampin, decreases exposure to treprostinil. It is unclear if the safety and efficacy of treprostinil by the inhalation route are altered by inhibitors or inducers of CYP2C8.
Limited case reports of treprostinil use in pregnant women are insufficient to inform a drug-associated risk of adverse developmental outcomes. However, pulmonary arterial hypertension is associated with an increased risk of maternal and fetal mortality. There are no data on the presence of treprostinil in human milk, the effects on the breastfed infant, or the effects on milk production.
Safety and effectiveness in pediatric patients have not been established.
Across clinical studies used to establish the effectiveness of TYVASO in patients with PAH and PH‑ILD, 268 (47.8%) patients aged 65 years and over were enrolled. The treatment effects and safety pro in geriatric patients were similar to younger patients. In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of hepatic, renal, or cardiac dysfunction, and of concomitant diseases or other drug therapy.
Pulmonary Arterial Hypertension (WHO Group 1)
In a 12-week, placebo-controlled study (TRIUMPH I) of 235 patients with PAH (WHO Group 1 and nearly all NYHA Functional Class III), the most common adverse reactions seen with TYVASO in ≥4% of PAH patients and more than 3% greater than placebo were cough (54% vs 29%), headache (41% vs 23%), throat irritation/pharyngolaryngeal pain (25% vs 14%), nausea (19% vs 11%), flushing (15% vs <1%), and syncope (6% vs <1%). In addition, adverse reactions occurring in ≥4% of patients were dizziness and diarrhea.
In a 3-week, open-label, single-sequence, safety and tolerability study (BREEZE) conducted in 51 patients on stable doses of TYVASO who switched to a corresponding dose of TYVASO DPI, the most commonly reported adverse events seen with TYVASO DPI in ≥4% of PAH patients during the 3-week treatment phase included cough (35.3%), headache (15.7%), dyspnea (7.8%), and nausea (5.9%).
Pulmonary Hypertension Associated with ILD (WHO Group 3)
In a 16-week, placebo-controlled study (INCREASE) of 326 patients with PH-ILD (WHO Group 3), adverse reactions with TYVASO were similar to the experience in studies of PAH.
Please see Full Prescribing Information for TYVASO or TYVASO DPI, Instructions for Use manuals for TD-100 and TD-300 TYVASO® Inhalation System and TYVASO DPI™ Inhalation Powder, and additional information at or call 1‑877‑UNITHER (1-877-864-8437).
United Therapeutics: Enabling Inspiration
At United Therapeutics, our vision and mission are one. We use our enthusiasm, creativity, and persistence to innovate for the unmet medical needs of our patients and to benefit our other stakeholders. We are bold and unconventional. We have fun, we do good. We are the first publicly-traded biotech or pharmaceutical company to take the form of a public benefit corporation (PBC). Our public benefit purpose is to provide a brighter future for patients through (a) the development of novel pharmaceutical therapies; and (b) technologies that expand the availability of transplantable organs.
You can learn more about what it means to be a PBC here: unither.com/PBC.
Statements included in this press release that are not historical in nature are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include, among others, statements relating to upcoming medical conference posters and presentations, our ARTISAN and TETON clinical studies, our ability to create value and sustain our success in the long-term, as well as our efforts to develop technologies that either delay the need for transplantable organs or expand the supply of transplantable organs. These forward-looking statements are subject to certain risks and uncertainties, such as those described in our periodic reports filed with the Securities and Exchange Commission, that could cause actual results to differ materially from anticipated results. Consequently, such forward-looking statements are qualified by the cautionary statements, cautionary language and risk factors set forth in our periodic reports and documents filed with the Securities and Exchange Commission, including our most recent Annual Report on Form 10-K, Quarterly Reports on Form 10-Q, and Current Reports on Form 8-K. We claim the protection of the safe harbor contained in the Private Securities Litigation Reform Act of 1995 for forward-looking statements. We are providing this information as of April 18, 2023, and assume no obligation to update or revise the information contained in this press release whether as a result of new information, future events, or any other reason.
REMODULIN, ORENITRAM, and TYVASO are registered trademarks of United Therapeutics Corporation.
UHEART is a trademark of United Therapeutics Corporation.
View source version on businesswire.com:
Dewey Steadman at (202) 919-4097
Source: United Therapeutics Corporation
View this news release online at:
DUBLIN, Feb. 3, 2023 /PRNewswire/ -- The "Pulmonary Arterial Hypertension (PAH) Drugs Market: Global Industry Trends, Share, Size, Growth, Opportunity and Forecast 2022-2027" report has been added to
The global pulmonary arterial hypertension (PAH) drugs market size reached US$ 6.9 Billion in 2021. Looking forward, the publisher expects the market to reach US$ 9.4 Billion by 2027, exhibiting a CAGR of 5.29% during 2021-2027.
Keeping in mind the uncertainties of COVID-19, we are continuously tracking and evaluating the direct as well as the indirect influence of the pandemic on different end use sectors. These insights are included in the report as a major market contributor.
Pulmonary arterial hypertension (PAH) refers to a life-threatening medical condition characterized by high blood pressure in the arteries that connect the heart to the lungs. It causes the artery walls to tighten and narrow down, thereby exerting additional pressure on the heart to pump blood and weakening the muscles.
In adverse cases, it can also compromise the heart's capacity to pump blood, thus eventually causing heart failure. PAH is characterized by shortness of breath, fatigue and swelling in ankles and legs. It is diagnosed through various tests, such as an echocardiogram, computer tomography (CT) scans, chest X-rays and ventilation-perfusion scans.
It is usually treated using various drugs, such as endothelin receptor antagonists (ERAs), vasodilators, calcium channel blockers (CCBs), anticoagulants, diuretics and cardiac glycosides. These drugs can be inhaled, injected or orally administered.
The increasing prevalence of cardiovascular and pulmonary disorders is one of the key factors driving the growth of the market. Furthermore, the rising geriatric population that is more susceptible to such medical ailments is providing a boost to the market growth.
In line with this, changes in lifestyles, such as excessive alcohol consumption, a lack of physical activity, and unhealthy dietary patterns, have enhanced the risks of hypertension and high blood pressure.
This, along with the development of novel orphan drugs and technologically advanced devices for the treatment of PAH, is favoring the market growth. Other factors, including increasing awareness among the masses regarding the available treatment alternatives for PAH, and improving healthcare infrastructure across the globe, are expected to drive the market further.
The report has also analysed the competitive landscape of the market with some of the key players being Actelion Pharmaceuticals Ltd (Johnson & Johnson), Arena Pharmaceuticals Inc., AstraZeneca PLC, Bayer Aktiengesellschaft, Daiichi Sankyo Company Limited, Gilead Science Inc., GlaxoSmithKline PLC, Merck KGaA, Novartis International AG, Pfizer Inc. and United Therapeutics Corporation.
Key Questions Answered in This Report:
How has the global pulmonary arterial hypertension (PAH) drugs market performed so far and how will it perform in the coming years?
What has been the impact of COVID-19 on the global pulmonary arterial hypertension (PAH) drugs market?
What are the key regional markets?
What is the breakup of the market based on the drug class?
What is the breakup of the market based on the route of administration?
What is the breakup of the market based on the end user?
What are the various stages in the value chain of the industry?
What are the key driving factors and challenges in the industry?
What is the structure of the global pulmonary arterial hypertension (PAH) drugs market and who are the key players?
What is the degree of competition in the industry?
Key Topics Covered:
2 Scope and Methodology
3 Executive Summary
4.2 Key Industry Trends
5 Global Pulmonary Arterial Hypertension (PAH) Drugs Market
5.1 Market Overview
5.2 Market Performance
5.3 Impact of COVID-19
5.4 Market Forecast
6 Market Breakup by Drug Class
6.1 Endothelin Receptor Antagonists (ERAs)
6.1.1 Market Trends
6.1.2 Market Forecast
6.2.1 Market Trends
6.2.2 Market Forecast
6.3 Phosphodiesterase-5 (PDE-5) Inhibitors
6.3.1 Market Trends
6.3.2 Market Forecast
6.4 Soluble Guanylate Cyclase (sGC) Stimulators
6.4.1 Market Trends
6.4.2 Market Forecast
6.5 Calcium Channel Blockers (CCBs)
6.5.1 Market Trends
6.5.2 Market Forecast
6.6 Prostacyclin and Prostacyclin Analogs
6.6.1 Market Trends
6.6.2 Market Forecast
6.7.1 Market Trends
6.7.2 Market Forecast
7 Market Breakup by Route of Administration
7.1.1 Market Trends
7.1.2 Market Forecast
7.2.1 Market Trends
7.2.2 Market Forecast
7.3 Oral Administration
7.3.1 Market Trends
7.3.2 Market Forecast
8 Market Breakup by End User
8.1.1 Market Trends
8.1.2 Market Forecast
8.2.1 Market Trends
8.2.2 Market Forecast
8.3.1 Market Trends
8.3.2 Market Forecast
9 Market Breakup by Region
10 SWOT Analysis
11 Value Chain Analysis
12 Porters Five Forces Analysis
13 Price Analysis
14 Competitive Landscape
14.1 Market Structure
14.2 Key Players
14.3 Profiles of Key Players
14.3.1 Actelion Pharmaceuticals Ltd (Johnson & Johnson)
184.108.40.206 Company Overview
220.127.116.11 Product Portfolio
14.3.2 Arena Pharmaceuticals Inc.
18.104.22.168 Company Overview
22.214.171.124 Product Portfolio
126.96.36.199 SWOT Analysis
14.3.3 AstraZeneca PLC
188.8.131.52 Company Overview
184.108.40.206 Product Portfolio
220.127.116.11 SWOT Analysis
14.3.4 Bayer Aktiengesellschaft
18.104.22.168 Company Overview
22.214.171.124 Product Portfolio
126.96.36.199 SWOT Analysis
14.3.5 Daiichi Sankyo Company Limited
188.8.131.52 Company Overview
184.108.40.206 Product Portfolio
220.127.116.11 SWOT Analysis
14.3.6 Gilead Science Inc.
18.104.22.168 Company Overview
22.214.171.124 Product Portfolio
126.96.36.199 SWOT Analysis
14.3.7 GlaxoSmithKline PLC
188.8.131.52 Company Overview
184.108.40.206 Product Portfolio
220.127.116.11 SWOT Analysis
14.3.8 Merck KGaA
18.104.22.168 Company Overview
22.214.171.124 Product Portfolio
126.96.36.199 SWOT Analysis
14.3.9 Novartis International AG
188.8.131.52 Company Overview
184.108.40.206 Product Portfolio
14.3.10 Pfizer Inc.
220.127.116.11 Company Overview
18.104.22.168 Product Portfolio
22.214.171.124 SWOT Analysis
14.3.11 United Therapeutics Corporation
126.96.36.199 Company Overview
188.8.131.52 Product Portfolio
184.108.40.206 SWOT Analysis
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