(MP-004)-_专利_临床

概要

基本信息

药物类型

单克隆抗体

别名

YP-004、MP-004

靶点-

作用机制-

治疗领域

肿瘤

在研适应症-

非在研适应症

肿瘤

原研机构

York Pharma (R&D) Ltd.

在研机构-

非在研机构

York Pharma Plc

最高研发状态(全球)终止药物发现

首次获批日期(全球)-

最高研发状态(中国)-

特殊审评-

关联

100 项与 MP-004 相关的专利（医药）

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1

项与 MP-004 相关的文献（医药）

1993-01-01·Cytotechnology4区 · 生物学

Effect of some constituents of chicken egg yolk lipoprotein on the growth and IgM production of human-human hybridoma cells and other human-derived cells.

4区 · 生物学

Article

作者: K Shinohara ; T Fukushima ; M Suzuki ; M Tsutsumi ; M Kobori ; Z L Kong

Chicken egg yolk lipoprotein (YLP) was partially fractionated into some constituents, and the effect of constituents of YLP were examined on the growth and immunoglobulin (IgM and IgG) secretion of a HB4C5 human-human hybridoma cell line cultured in serum-free medium. Among the fractions, YP-1 and YP-2 fractions (LDL-rich fractions) were found to enhance the growth and IgM secretion of HB4C5 cells. The promoting activity was found in the commercial LDL. The lipid fraction in YP-2 fraction conjugated with 2-maltosyl-a-cyclodextrin was found to enhance the growth and IgM secretion of HB4C5 cells. Livetin-rich YP-3 and YP-4 fractions had no significant promoting activity. Commercial gamma-livetin and phosphatidyl choline possessed no growth-promoting activity. Phosphatidyl choline enhanced the IgM secretion of HB4C5 cells.