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更新于：2025-05-07

Indium (111In) Biciromab(Janssen Global Services LLC)

更新于：2025-05-07

概要

概要

基本信息

药物类型

抗体偶联核素、诊断用放射药物

别名

FibriScint

靶点

FGB

作用方式

抑制剂

作用机制

FGB抑制剂(纤维蛋白原β链抑制剂)

治疗领域-

在研适应症-

非在研适应症-

原研机构

Janssen Global Services LLC

在研机构-

非在研机构-

权益机构-

最高研发阶段-

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构/序列

分子式C10H11BrN2O3

InChIKeyDYODAJAEQDVYFX-UHFFFAOYSA-N

CAS号561-86-4

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关联

100 项与 Indium (111In) Biciromab(Janssen Global Services LLC) 相关的临床结果

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100 项与 Indium (111In) Biciromab(Janssen Global Services LLC) 相关的转化医学

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100 项与 Indium (111In) Biciromab(Janssen Global Services LLC) 相关的专利（医药）

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128

项与 Indium (111In) Biciromab(Janssen Global Services LLC) 相关的文献（医药）

2025-04-01·Anti-Infective Agents

In silico Screening of Plectranthus amboinicus and Hyptis suaveolens Phytochemicals: Novel Repellents Targeting Odorant Binding Proteins of Aedes aegypti and Aedes albopictus

作者: Sisubalan, Natarajan ; Wilson, Jeyaraj John ; Chaiyasut, Chaiyavat ; Sudhakar, Dharmarajan Raja ; Sivamaruthi, Bhagavathi Sundaram ; Jebastin, Thomas ; Sevarkodiyone, Subramanian ; Abuthakir, Mohamed Husain Syed

Background and Aim:Mosquitoes significantly threaten public health, transmitting dangerous diseases to humans and animals. Conventional insecticide spraying, while common, has limitations in effectively controlling vector-borne diseases. Many chemical pesticides harm humans and animals, and some persist in the environment and cause toxic effects. Recently, there has been renewed interest in plant-based products due to concerns about insecticide re-sistance, cross-resistance, potential toxicity associated with synthetic options, and rising costs. Therefore, this study aimed to screen the Plectranthus amboinicus and Hyptis suaveolens phy-tochemicals targeting the odorant binding proteins (OBPs) of Aedes aegypti and Aedes albopic-tus.Methods:In this study, we conducted molecular docking analyses using specific plant-derived compounds from H. suaveolens and P. amboinicus.Results:We focused on the interaction of these compounds with OBPs from dengue and chikungunya vectors (Aedes aegypti and Aedes albopictus). The selected phytochemical com-pounds exhibited strong binding with the OBP of both Ae. aegypti and Ae. albopictus. Tetrahy-drofuran-2-carboxylic acid, Carvacryl acetate, and Brallobarbital showed high binding affinity and significant interaction with Ae. aegypti. Tetrahydrofuran-2-carboxylic acid and 3-Methyl-4-isopropylphenol also demonstrated substantial binding affinity and effective interaction with Ae. albopictus OBP.Conclusion:These findings suggest that the identified compounds can potentially disrupt the attraction of mosquitoes to humans, thus reducing human-vector contact. They may offer a promising alternative for developing natural and efficient mosquito repellents, surpassing cur-rently used synthetic options like N, N-diethyl-meta-toluamide, and other conventional repel-lents.

2024-09-01·Microbial Pathogenesis

Deciphering the Potential Therapeutic Effects of Hydnocarpus wightianus Seed Extracts using in vitro and in silico approaches

Article

作者: Ramesh, Manikandan ; Veerabharathi, Prathiyanga ; Kathiresan, Nachammai ; Awere, Collince Omondi ; Harini, Kasilingam ; Veera Ravi, Arumugam ; Langeswaran, Kulanthaivel ; Pandi, Sangavi

Phytocompounds possess the potential to treat a broad spectrum of disorders due to their remarkable bioactivity. Naturally occurring compounds possess lower toxicity profiles, which making them attractive targets for drug development. Hydnocarpus wightianus seeds were extracted using ethanol, acetone, and hexane solvents. The extracts were evaluated for phytochemicals screening and other therapeutic characteristics, such as free radicals scavenging, anti α-amylase, anti α-glucosidase, and anti-bacterial activities. The ethanolic extract exhibited noteworthy antibacterial characteristics and demonstrated considerable antioxidant, and anti-diabetic effects. The IC50 value of the ethanolic extract for Dpph, α-amylase, and α-glucosidase were found to be 77.299 ± 3.381 μg/mL, 165.56 2.56 μg/mL, and 136.58 ± 5.82 μg/mL, respectively. The ethanolic extract was effective against Methicillin resistant Staphylococcus aureus (26 mm zone of inhibition at 100 μL concentration). Molecular docking investigations revealed the phytoconstituent's inhibitory mechanisms against diabetic, free radicals, and bacterial activity. Docking score for phytocompounds against targeted protein varies from -7.2 to -5.1 kcal/mol. The bioactive compounds present in the ethanolic extract were identified by Gas chromatography/Mass spectrometry analysis, followed by molecular docking and molecular dynamic simulation studies to further explore the phytoconstituent's inhibitory mechanism of α-glucosidase, ∝-amylase, radical scavenging, and bacterial activity. The electronic structure and possible pharmacological actions of the phytocompound were revealed through the use of Density Functional Theory (DFT) analysis. Computational and in vitro studies revealed that these identified compounds have anti-diabetic, anti-oxidant, and anti-bacterial activities against antibiotic-resistant strain of Staphylococcus aureus.

2021-12-22·Main Group Chemistry

Investigating Functionalization Impacts on Structural Features of Barbituric Acid Derivatives: DFT Approach

作者: Hajali, Narjes ; Seif, Ahmad ; Taghva Manesh, Afshin

Density functional theory (DFT) calculations were performed to investigate electronic and structural properties of barbituric acid (BA) and sixtheen of its derivatives to show impacts of structural functionalization on the features of parent BA. The models were optimized and the minimum energy structures were confirmed by frequency calculations. Molecular and atomic descriptors were evaluated for the optimized models, in which the results of formation binding strength and molecular orbital features indicated significance of such functionalization processes on the observed properties. The highest occupied and the lowest unoccupied molecular orbitals (HOMO and LUMO) and their related parameters all indicated magnitudes of changes from one molecule to another one. Furthermore, atomic scale quadrupole coupling constants (Cq) were evaluated for the nitrogen and oxygen atoms of BA compounds showing significance of structural functionalization impacts on the atomic properties of parent BA. As a consequence, such structural analyses of BA compounds could show their characteristic features for further developments especially for their efficient pharmaceutical applications.

100 项与 Indium (111In) Biciromab(Janssen Global Services LLC) 相关的药物交易

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