SCH57404, an antifungal agent possessing the rare sodaricin skeleton and a tricyclic sugar moiety
4区 · 医学
作者: Coval, Stephen J. ; Puar, Mohindar S. ; Phife, David W. ; Terracciano, Joseph S. ; Patel, Mahesh
The extract from an unidentified fungus, SCF1028A, inhibited Candida albicans. Conditions productive for biol. activity were developed and upon harvest, pure SCH57404 was recovered as the compound responsible for the antifungal activity. Typical yield was 19 mg/L. Structure anal. of SCH57404 showed it to be remarkably similar to BE31405. Both are related to sordarin, a rare class of tetracyclic diterpenes.