MS-136(MS-136) - _专利_临床

概要

基本信息

药物类型

未知

别名

靶点-

作用机制-

治疗领域

肿瘤消化系统疾病皮肤和肌肉骨骼疾病

在研适应症-

非在研适应症

乳腺癌肝癌

原研机构

EPIX Pharmaceuticals, Inc.

在研机构-

非在研机构

EPIX Pharmaceuticals, Inc.

最高研发阶段终止药物发现

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 MS-136 相关的临床结果

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100 项与 MS-136 相关的转化医学

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100 项与 MS-136 相关的专利（医药）

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1

项与 MS-136 相关的文献（医药）

2018-04-01·Biotechnology Letters4区 · 工程技术

Engineering phytosterol transport system in Mycobacterium sp. strain MS136 enhances production of 9α-hydroxy-4-androstene-3,17-dione

4区 · 工程技术

Article

作者: He, Kun ; Sun, Hong ; Song, Hao

OBJECTIVESTo enhance the yield of 9α-hydroxy-4-androstene-3,17-dione (9-OHAD) from phytosterols, a phytosterol transport system was constructed in Mycobacterium sp. strain MS136.RESULTS9-OHAD can be produced via the controlled degradation of phytosterols by mycobacteria. This involves an active transport process that requires trans-membrane proteins and ATP. A phytosterol transport system from Mycobacterium tuberculosis H37Rv was constructed in Mycobacterium sp. strain MS136 by co-expression of an energy-related gene, mceG, and two integrated membrane protein genes, yrbE4A and yrbE4B. The resultant of the Mycobacterium sp. strain MS136-GAB gave 5.7 g 9-OHAD l^-1, which was a 20% increase over 4.7 g l^-1 by the wild-type strain. The yield of 9-OHAD was increased to 6.0 g l^-1 by optimization of fermentation conditions, when 13 g phytosterols l^-1 were fermented for 84 h in 30 ml biotransformation medium in shake flasks.CONCLUSIONSPhytosterol transport system plays an active role in the uptake and transport of sterols, cloning of the system improved the mass transfer of phytosterols and increased the production of 9-OHAD.

100 项与 MS-136 相关的药物交易

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