更新于：2024-11-04

L-Leucine/L-Isoleucine/L-Valine/L-Lysine Acetate/L-Threonine/L-Tryptophan/L-Methionine/L-Cysteine/L-Phenylalanine/L-Tyrosine/L-Arginine/L-Histidine/L-Alanine/L-Proline/L-Serine/L-Aspartic Acid/L-Glutamic Acid

L-亮氨酸/L-异亮氨酸/L-缬氨酸/L-醋酸赖氨酸/L-苏氨酸/L-色氨酸/L-甲硫氨酸/L-半胱氨酸/L-苯丙氨酸/L-酪氨酸/L-精氨酸/L-组氨酸/ L -丙氨酸/L-脯氨酸/L-丝氨酸/L-天冬氨酸/L-谷氨酸

更新于：2024-11-04

概要

概要

基本信息

药物类型

小分子化药

别名

Kidmin、キドミン

靶点-

作用机制-

治疗领域

内分泌与代谢疾病血液及淋巴系统疾病

在研适应症

营养不良低蛋白血症

非在研适应症-

原研机构

Otsuka Pharmaceutical Factory, Inc.

在研机构

Fresenius Kabi Canada Ltd.

Otsuka Pharmaceutical Factory, Inc.

非在研机构-

最高研发阶段批准上市

首次获批日期

日本 (2008-04-03),

低蛋白血症

最高研发阶段(中国)-

特殊审评-

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关联

100 项与 L-亮氨酸/L-异亮氨酸/L-缬氨酸/L-醋酸赖氨酸/L-苏氨酸/L-色氨酸/L-甲硫氨酸/L-半胱氨酸/L-苯丙氨酸/L-酪氨酸/L-精氨酸/L-组氨酸/ L -丙氨酸/L-脯氨酸/L-丝氨酸/L-天冬氨酸/L-谷氨酸相关的临床结果

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100 项与 L-亮氨酸/L-异亮氨酸/L-缬氨酸/L-醋酸赖氨酸/L-苏氨酸/L-色氨酸/L-甲硫氨酸/L-半胱氨酸/L-苯丙氨酸/L-酪氨酸/L-精氨酸/L-组氨酸/ L -丙氨酸/L-脯氨酸/L-丝氨酸/L-天冬氨酸/L-谷氨酸相关的转化医学

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100 项与 L-亮氨酸/L-异亮氨酸/L-缬氨酸/L-醋酸赖氨酸/L-苏氨酸/L-色氨酸/L-甲硫氨酸/L-半胱氨酸/L-苯丙氨酸/L-酪氨酸/L-精氨酸/L-组氨酸/ L -丙氨酸/L-脯氨酸/L-丝氨酸/L-天冬氨酸/L-谷氨酸相关的专利（医药）

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项与 L-亮氨酸/L-异亮氨酸/L-缬氨酸/L-醋酸赖氨酸/L-苏氨酸/L-色氨酸/L-甲硫氨酸/L-半胱氨酸/L-苯丙氨酸/L-酪氨酸/L-精氨酸/L-组氨酸/ L -丙氨酸/L-脯氨酸/L-丝氨酸/L-天冬氨酸/L-谷氨酸相关的文献（医药）

2021-10-01·Bioactive materials1区 · 材料科学

l-cysteine-modified chiral gold nanoparticles promote periodontal tissue regeneration

1区 · 材料科学

ArticleOA

作者: Zhou, Hong ; Zhang, Yangheng ; Yan, Fuhua ; Xiao, Yin ; Kong, Na ; Wang, Zezheng ; Fu, Huangmei ; Yang, Wenrong ; Zhang, Shuang

Gold nanoparticles (AuNPs) with surface-anchored molecules present tremendous potential in tissue regeneration. However, little is known about chiral-modified AuNPs. In this study, we successfully prepared L/D-cysteine-anchored AuNPs (L/D-Cys-AuNPs) and studied the effects of chiral-modified AuNPs on osteogenic differentiation and autophagy of human periodontal ligament cells (hPDLCs) and periodontal tissue regeneration. In vitro, more L-Cys-AuNPs than D-Cys-AuNPs tend to internalize in hPDLCs. L-Cys-AuNPs also significantly increased the expression of alkaline phosphatase, collagen type 1, osteocalcin, runt-related transcription factor 2, and microtubule-associated protein light chain 3 II and decreased the expression of sequestosome 1 in hPDLCs compared to the expression levels in the hPDLCs treated by D-Cys-AuNPs. In vivo tests in a rat periodontal-defect model showed that L-Cys-AuNPs had the greatest effect on periodontal-tissue regeneration. The activation of autophagy in L-Cys-AuNP-treated hPDLCs may be responsible for the cell differentiation and tissue regeneration. Therefore, compared to D-Cys-AuNPs, L-Cys-AuNPs show a better performance in cellular internalization, regulation of autophagy, cell osteogenic differentiation, and periodontal tissue regeneration. This demonstrates the immense potential of L-Cys-AuNPs for periodontal regeneration and provides a new insight into chirally modified bioactive nanomaterials.

2017-09-01·Drugs in R&D4区 · 医学

Comparative Effect of Calcium Channel Blockers on Glomerular Function in Hypertensive Patients with Diabetes Mellitus

4区 · 医学

ArticleOA

作者: Asai, Satoshi ; Takeuchi, Satoshi ; Nakayama, Tomohiro ; Tezuka, Kotoe ; Nishida, Yayoi ; Takahashi, Yasuo

BACKGROUND:

We conducted a retrospective cohort study to evaluate and compare the longitudinal effect of monotherapy with L-, L/T-, L/N-, and L/N/T-type calcium channel blockers (CCBs) on estimated glomerular filtration rate (eGFR), and to investigate the association of treatment duration with eGFR in diabetic patients with hypertension.

METHODS:

Using a clinical database, we identified new users of five CCBs, i.e. amlodipine (L-type, n = 693), nifedipine (L-type, n = 189), azelnidipine (L/T-type, n = 91), benidipine (L/N/T-type, n = 183), and cilnidipine (L/N-type, n = 61). We used a multivariable regression model to evaluate and compare the effects of these drugs on eGFR and serum creatinine, up to 12 months after initiation of study drug administration.

RESULTS:

There was no significant association between treatment duration and both eGFR and serum creatinine level with all CCB types. In addition, there was no significant difference in mean change in eGFR among the five CCBs, with any treatment duration.

CONCLUSIONS:

Our findings suggest that monotherapy with an L-, L/T-, L/N/T-, or L/N-type CCB may have little influence on renal function parameters and may be safely used in hypertensive patients with diabetes.

100 项与 L-亮氨酸/L-异亮氨酸/L-缬氨酸/L-醋酸赖氨酸/L-苏氨酸/L-色氨酸/L-甲硫氨酸/L-半胱氨酸/L-苯丙氨酸/L-酪氨酸/L-精氨酸/L-组氨酸/ L -丙氨酸/L-脯氨酸/L-丝氨酸/L-天冬氨酸/L-谷氨酸相关的药物交易

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