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更新于：2025-03-20

ST-1859

更新于：2025-03-20

概要

概要

基本信息

药物类型

小分子化药

别名-

靶点-

作用方式-

作用机制-

治疗领域

神经系统疾病

在研适应症-

非在研适应症

阿尔茨海默症

原研机构

Sigma-Tau BV

在研机构-

非在研机构

Alfasigma USA, Inc.Sigma-Tau BV

最高研发阶段终止临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C21H16O2

InChIKeyZPANWZBSGMDWON-UHFFFAOYSA-N

CAS号1096-84-0

关联

100 项与 ST-1859 相关的临床结果

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100 项与 ST-1859 相关的转化医学

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100 项与 ST-1859 相关的专利（医药）

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235

项与 ST-1859 相关的文献（医药）

2024-02-16·The Journal of Organic Chemistry

DMSO–DCE Triggered Chemodivergent C-Methylenation of Electron-Rich Arenes: An Easy Access to Diarylmethanes

Article

作者: Swain, Swayamprava ; Dalai, Pallaba Ganjan ; Panda, Niranjan

The chemodivergent property of dimethyl sulfoxide (DMSO) along with 1,2-dichloroethane (DCE) was exploited for the incorporation of a methylene group to form diarylmethanes through a dearomatization/rearomatization process. Methyl(methylene)sulfonium ions (CH₂=S⁺-Me) were generated by simple heating of commonly used solvents such as DMSO and DCE. These ions were subsequently trapped by electron-rich arenes and heteroarenes, resulting in the synthesis of both symmetrical and unsymmetrical diarylmethanes. This protocol was further extended to access N-methylenamides by reacting 2-naphthol with amides or nitriles in the presence of DMSO and DCE.

2023-03-01·Russian Journal of General Chemistry

Synthesis of Calix[4]resorcinarene and 1,1′-Dinaphthylmethane Amide Derivatives and Their Ability to Extract Metal Cations

作者: Maslennikova, V. I. ; Kamkina, A. V. ; Isaeva, S. A. ; Serkova, O. S. ; Glushko, V. V. ; Toropygin, I. Yu.

Aminolysis of ester derivatives of 1,1'-dinaphthylmethane and rctt-calix[4]resorcinarene afforded a series of ligands differing in the mol. platform structure, the number of electron-donor sites, the nature of terminal amide component, the nature and size of the spacers connecting the polycyclic core with the amide group.Using liquid extraction method, the effect of ligand structural features on its ability to recognize and bind s-, p-, d-, and f-metal cations was investigated, and the stoichiometry of formed complexes was calculated

2022-04-01·Research on Chemical Intermediates

Retrievable magnetic copper ferrite nanoparticles: an efficient catalyst for air oxidative cyclization of bisnaphthols

作者: Saeedian, Fateme ; Bahiraei, Hamed ; Shiri, Azam ; Khorramabadi-zad, Ahmad

Herein, a green and efficient heterogeneous and photocatalytic system for the oxidation of bisnaphthols in acetonitrile under light-emitting diode will be presented.In this reaction, aerial oxygen and H₂O₂ have been used as oxidant in the presence of copper ferrite nanoparticles and N-hydroxyphthalimide as an organic co-catalyst.Copper ferrite nanoparticles were magnetically separated, the efficiency of which remained nearly unchanged up to five cycles.Magnetic copper ferrite nanoparticles were synthesized by sol-gel method and characterized by XRD, FT-IR, SEM, TEM, VSM and DRS anal.In this project, both sets of diastereomers were formed.

100 项与 ST-1859 相关的药物交易

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