组氨酸锌(Zinc Histidine Hydrate) - 在研适应症：缺锌_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Histidine zinc hydrate、Zintus、ジンタス

靶点-

作用机制-

治疗领域

其他疾病

在研适应症

缺锌

非在研适应症-

原研机构-

在研机构

Nobel Pharma, Inc.

非在研机构-

最高研发阶段批准上市

首次获批日期

日本 (2024-03-26),

缺锌

最高研发阶段(中国)-

特殊审评-

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结构

分子式C12H16N6O4Zn

InChIKeyMOFAEFYKLUVFKG-MDTVQASCSA-L

CAS号2713449-37-5

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关联

100 项与组氨酸锌相关的临床结果

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100 项与组氨酸锌相关的转化医学

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100 项与组氨酸锌相关的专利（医药）

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1

项与组氨酸锌相关的文献（医药）

2024-10-01·International Journal of Biological Macromolecules

Efficient synthesis of lactic acid from cellulose through the synergistic effect of zinc chloride hydrate and metal salts

Article

作者: Liang, Jilei ; Tang, Zhe ; Su, Jianhui

The chemocatalystic conversion of cellulose, the main component of lignocellulosic biomass, to building-block chemicals in water under mild conditions, is an ideal but highly challenging process due to the robust crystal structure of cellulose. It is also the key to establishing a sustainable biomass-based chemical process. Here, we present a highly efficient and selective chemocatalytic hydrolysis of cellulose using ZnCl₂·3H₂O hydrate as the pretreatment reagent and water-compatible metal salts - ErCl₃ as the catalyst, into lactic acid (LA), which is an important chemical building-block widely utilized in the food industry and in the production of chemicals and biodegradable plastic. With 94.0 % conversion of cellulose, an impressive LA yield of 84.6 % was achieved at 170 °C after 4 h under ambient air pressure in water. High yields of LA were also obtained from other carbohydrates, such as fructose (68.3 %), glucose (52.7 %), starch (54.4 %), and inulin (67 %). A series of experiments demonstrated that Er(III) combination with water catalyzed cascading steps of soluble cellulose into LA after ZnCl₂·3H₂O hydrate disrupted the hydrogen bonds in the cellulose, Zn(II) played an indirect role by promoting LA formation through inhibition of side reactions. A plausible mechanism was proposed for the chemocatalytic conversion of cellulose to LA.

100 项与组氨酸锌相关的药物交易

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