Yersinia Pestis Vaccine (Syntiron)(Yersinia Pestis Vaccine (Syntiron))

概要

基本信息

药物类型

预防性疫苗

别名-

靶点-

作用方式-

作用机制-

治疗领域

感染其他疾病

在研适应症-

非在研适应症

鼠疫

原研机构

Syntiron LLC

在研机构-

非在研机构

Syntiron LLC

权益机构-

最高研发阶段无进展临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 Yersinia Pestis Vaccine (Syntiron) 相关的临床结果

登录后查看更多信息

100 项与 Yersinia Pestis Vaccine (Syntiron) 相关的转化医学

登录后查看更多信息

100 项与 Yersinia Pestis Vaccine (Syntiron) 相关的专利（医药）

登录后查看更多信息

2

项与 Yersinia Pestis Vaccine (Syntiron) 相关的文献（医药）

2019-08-30·The Journal of Infectious Diseases2区 · 医学

Postexposure Administration of a Yersinia pestis Live Vaccine for Potentiation of Second-Line Antibiotic Treatment Against Pneumonic Plague

2区 · 医学

Article

作者: Mamroud, Emanuelle ; Zauberman, Ayelet ; Tidhar, Avital ; Levy, Yinon ; Chitlaru, Theodor ; Gur, David ; Vagima, Yaron ; Aftalion, Moshe

AbstractPneumonic plague, caused by Yersinia pestis, is a rapidly progressing contagious disease. In the plague mouse model, a single immunization with the EV76 live attenuated Y. pestis strain rapidly induced the expression of hemopexin and haptoglobin in the lung and serum, both of which are important in iron sequestration. Immunization against a concomitant lethal Y. pestis respiratory challenge was correlated with temporary inhibition of disease progression. Combining EV76-immunization and second-line antibiotic treatment, which are individually insufficient, led to a synergistic protective effect that represents a proof of concept for efficient combinational therapy in cases of infection with antibiotic-resistant strains.

1974-05-01·Journal of Infectious Diseases2区 · 医学

Live, Attenuated Yersinia pestis Vaccine: Virulent in Nonhuman Primates, Harmless to Guinea Pigs

2区 · 医学

Article

作者: K. F. Meyer ; M. Sung ; L. Foster ; G. Smith ; M. Brookman

100 项与 Yersinia Pestis Vaccine (Syntiron) 相关的药物交易

登录后查看更多信息