作者: Keerthana, Chenicheri Kizhakkeveettil ; Vijayan, Yadu ; Shifana, Sadiq C. ; Rayginia, Tennyson P. ; Harikumar, Kuzhuvelil B. ; Lankalapalli, Ravi S. ; Induja, D.K. ; James, Shirly ; Anto, Ruby John ; Aiswarya, Sreekumar U. ; Sundaram, Sankar

Introduction:Sorafenib (Sor) is the first-line treatment option in clinics for treating advanced unresectable hepatocellular carcinoma (HCC). However, acquired chemoresistance and adverse side effects associated with Sor monotherapy limit its clinical benefits. We have previously reported the exceptional anti-HCC potential of uttroside B (Utt-B), a furostanol saponin isolated in our lab from Solanum nigrum Linn. leaves. The current study has evaluated the supremacy of a combinatorial regimen of Sor and Utt-B over Sor monotherapy.Methods:MTT assay was used for In vitro cytotoxicity studies. A clonogenic assay was conducted to assess the anti-proliferative effect of the combination. Annexin V/PI staining, confocal microscopy, FACS cell cycle analysis, and Western blotting experiments were performed to validate the pro-apoptotic potential of the combination in HepG2 and Huh7 cell lines. Pharmacological safety evaluation was performed in Swiss albino mice.Results:Our results indicate that Utt-B augments Sor-induced cytotoxicity in HepG2 and Huh7 cells. The combination inhibits the proliferation of liver cancer cells by inducing apoptosis through activation of the caspases 7 and 3, leading to PARP cleavage. Furthermore, the combination does not induce any acute toxicity in vivo, even at a dose five times that of the effective therapeutic dose.Conclusion:Our results highlight the potential of Utt-B as an effective chemosensitizer, which can augment the efficacy of Sor against HCC and circumvent Sor-induced toxic side effects. Moreover, this is the first and only report to date on the chemosensitizing potential of Utt-B and the only report that demonstrates the therapeutic efficacy and pharmacological safety of a novel combinatorial regimen involving Utt-B and Sor for combating HCC.

2024-04-01·Biochemical and Biophysical Research Communications

Enhanced extracellular vesicles mediated uttroside B (Utt-B) delivery to Hepatocellular carcinoma cell: Pharmacokinetics based on PBPK modelling

Article

作者: Induja, D K ; Kalishwaralal, Kalimuthu ; Keerthana, Chenicheri K ; Shifana, Sadiq C ; Anto, Ruby John ; Azeez Nazeer, Abdul

Our prior investigation has confirmed that the anti-hepatocellular carcinoma activity of the plant saponin, specifically Uttroside B (Utt-B), derived from the leaves of Solanum nigrum Linn. This study concentrated on formulating a novel biocompatible nanocarrier utilizing Extracellular vesicles (EVs) to enhance the delivery of plant saponin into cells. The physicochemical attributes of Extracellular Vesicles/UttrosideB (EVs/Utt-B) were comprehensively characterized through techniques such as Transmission Electron Microscopy (TEM) and Fourier-transform infrared spectroscopy (FTIR). Despite the promising therapeutic potential of this uttroside B, mechanistic know-how about its entry into cells is still in its infancy. Our research sheds light on the extracellular vesicle-mediated mechanism facilitating the entry of the saponin into cells, a phenomenon confirmed through the use of by confocal microscopy. We further analysed drug-releasing kinetics and simulated the Pharmacokinetics by PBPK modelling. The simulated pharmacokinetics revealed the bioavailability of Uttroside-B in oral administration against intravenous administration.

2023-09-29·Medical oncology (Northwood, London, England)

Solanum nigrum Linn.: Advances in anti-cancer activity and mechanism in digestive system tumors.

Review

作者: Sun, Xueying ; Tan, Gang ; Zhao, Qi ; Yang, Jing ; Ji, Daolin ; Chen, Qian ; Hou, Li ; Li, Wang ; Luo, Xing ; Xu, Yi ; Pei, Hongyu

Cancer has currently become a serious public health issue in many countries worldwide, and tumors of the digestive system have attracted an increasing number of researchers' due to their numerous types, high proportion and wide area of occurrence. While tumors of the digestive system suffer from high mortality rates, leading to untimely diagnosis and a poor prognosis, making it necessary to update current treatment approaches such as surgery, radiation therapy, and chemotherapy. This highlights the importance of exploring novel therapeutic ideas and targets. Traditional Chinese medicine has a long history of clinical use due to its low toxicity and multi-factor targeting of multiple pathways. As a kind of traditional Chinese herb, S. nigrum Linn. is highly regarded for its proven antitumor activity. The aim of this study was to comprehensively recapitulate and analyze the anti-cancer effects and molecular mechanisms of treatment of gastrointestinal tumors with S. nigrum Linn. extracts and related compounds, including classical signaling pathways mediated by them as well as noncoding RNA pathways associated with tumor suppression. Components that have been found to be responsible for the anti-cancer activity of S. nigrum Linn. include solanine, solasonine, solamargine, a-L-rhhamnopyranose, uttroside B, degalactotigonin, glycoprotein, and other compounds. The underlying mechanisms of anti-cancer activity reflected in this study include apoptosis, cell cycle arrest, autophagy, anti-angiogenesis, suppression of metastasis and invasion, immune escape, and increased sensitivity to radiotherapy. S. nigrum Linn. has great potential in the treatment of tumors of the digestive system, and through further clinical trials and pharmacological mechanisms it has the potential to become a uniform and standardized anti-tumor drug.

项与 Uttroside-B 相关的新闻（医药）

2023-04-14

·PRNewswire

Q BioMed Inc. Chemotherapeutic Uttroside B, Receives Patent from United States Patent Office and Notice of Allowance for Europe

Company's Liver Cancer Drug Candidate IP Portfolio strengthened Company provides operational update on strategic opportunities NEW YORK, April 14, 2023 /PRNewswire/ -- Q BioMed Inc. (OTCQB: QBIO) a biotech acceleration and commercial stage company focused on licensing and acquiring undervalued biomedical assets in the healthcare sector, asset Uttroside B – has received a patent in the United States and a notice of allowance in Europe, adding to the already issued patents in Korea, Canada and Japan. In addition, recent results from pre-clinical pharmacokinetic testing have been very encouraging and the data supports advancing the program. Uttroside B shows tremendous value in the Liver Cancer Market and has received Orphan Drug designation from the FDA. The America Cancer Society () reported in this year alone, an estimated 42,000 adults in the United States will be diagnosed with primary liver cancer. It is also estimated that 30,000 deaths from this disease will occur this year. The 5-year survival rate is 20%, compared to just 3% 40 years ago. For the 44% of people who are diagnosed with liver cancer at an early stage, the 5-year survival rate is 34%. There is significant demand for better therapeutic alternatives in the space. Q BioMed has the exclusive rights to the technology through an agreement with the Rajiv Gandhi Centre for Biotechnology, an Autonomous Institute under the Department of Biotechnology, Government of India, and the Oklahoma Medical Research Foundation. In addition to successfully prosecuting its IP portfolio the company is engaged in finding strategic opportunities to best preserve and create value for its shareholders. Denis Corin, QBioMed Inc. CEO said, "We believe in the inherent value we have created in our pipeline. With the assistance of bankers and funding partners we are evaluating strategic opportunities including financing, mergers, and asset joint ventures or sale of assets in order to maximize value for our shareholders in a very difficult market." The company has an approved non-opioid cancer pain palliation asset that is an effective therapeutic, it's a non-opiate and can save hospitals millions of dollars in economic outcome improvements. In addition, it has a very promising liver cancer chemotherapeutic that has been granted US orphan drug status and several international patents, and recently was also granted a patent in USA. The plan is to advance this asset into the clinic in a non-US country where the government is offering 43% cash rebate and combined with US dollar strength would allow us to complete that clinical phase for 50% of the typical cost and potentially in a shorter timeframe. It previously reported the remarkable potency of Uttroside-B against liver cancer cells and believes it could be a very valuable drug candidate in the liver cancer market which has few therapeutics for a growing patient population. QBioMed has an equity stake in Mannin Research valued at approximately $3.5M USD. This asset value is expected to rise significantly as they advance their programs assisted by non-dilutive government funding already amounting to over $15M and which could exceed $100M over the next year. Data from the Mannin planned ARDS trial will support the filings for further indications, including kidney disease and glaucoma. Combined, the addressable market for these therapies is over $150 billion a year. The company believes these assets are far more valuable than the current market cap of the company and are determined to find a way to recognize that value for its shareholders and those that made these assets into promising therapeutics that could help many people around the world. While the company believes these corporate activities are building value, it is of course aware of the dismal stock performance. Unfortunately, its cap and debt structure coupled with the general macro-market uncertainty and specifically the biotech market capitulation, has resulted in a valuation for QBIO that they maintain, is not reflective of the inherent asset value within their portfolio. The current microcap and biotech funding climate is making raising capital very challenging and keeping up with the considerable expense of public company operations and professional fees has resulted in them not being able to timely file or annual report. The company is working on remedying that as soon as possible About Q BioMed Inc. Q BioMed Inc is a biotech acceleration and commercial stage company. Q BioMed is focused on licensing and acquiring undervalued biomedical assets in the healthcare sector. Q BioMed is dedicated to providing these target assets the strategic resources, developmental support, and expansion capital needed to ensure they meet their developmental potential, enabling them to provide products to patients in need‏. Please visit and sign up for regular updates. Forward-Looking Statements: This press release may contain "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Such statements include, but are not limited to, any statements relating to our growth strategy and product development programs and any other statements that are not historical facts. Forward-looking statements are based on management's current expectations and are subject to risks and uncertainties that could negatively affect our business, operating results, financial condition and stock price. Factors that could cause actual results to differ materially from those currently anticipated are: risks related to our growth strategy; risks relating to the results of research and development activities; our ability to obtain, perform under and maintain financing and strategic agreements and relationships; uncertainties relating to preclinical and clinical testing; our dependence on third-party suppliers; our ability to attract, integrate, and retain key personnel; the early stage of products under development; our need for substantial additional funds; government regulation; patent and intellectual property matters; competition; as well as other risks described in our SEC filings. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in our expectations or any changes in events, conditions or circumstances on which any such statement is based, except as required by law. Q BioMed Media Contact: Denis Corin CEO Investor Relations - Landon Capital: Keith Pinder +1(404) 995-6671 [email protected] SOURCE Q BioMed Inc.

孤儿药

2023-02-10

·PRNewswire

Q BioMed Inc. Chemotherapeutic Uttroside B, Receives Notice of Allowance for Patent from United States Patent Office

Uttroside B Has Shown Promising Results in Initial Pre-Clinical Testing NEW YORK, Feb. 10, 2023 /PRNewswire/ -- Q BioMed Inc. (OTCQB: QBIO) a biotech acceleration and commercial stage company focused on licensing and acquiring undervalued biomedical assets in the healthcare sector, asset Uttroside B – is expected to receive a patent in the United States, adding to the already issued patents in Korea, Canada and Japan. In addition, recent results from pre-clinical pharmacokinetic testing have been very encouraging and the data supports advancing the program. Uttroside B shows tremendous value in the Liver Cancer Market. Uttroside B has also received Orphan Drug designation from the FDA. The America Cancer Society () reported in this year alone, an estimated 42,000 adults in the United States will be diagnosed with primary liver cancer. It is also estimated that 30,000 deaths from this disease will occur this year. The 5-year survival rate is 20%, compared to just 3% 40 years ago. For the 44% of people who are diagnosed with liver cancer at an early stage, the 5-year survival rate is 34%. There is significant demand for better therapeutic alternatives in the space. Q BioMed announced in 2021 that it has received Orphan Drug Status from the FDA. Q BioMed Inc. is prosecuting patents in multiple jurisdictions and has received patents from Canada, Korea and Japan and has now received notice of an allowable patent in the USA. The Patent is titled "Uttroside-B and Derivatives Thereof as Therapeutics for Hepatocellular Carcinoma (HCC)". Q BioMed has the exclusive rights to the technology through an agreement with the Rajiv Gandhi Centre for Biotechnology, an Autonomous Institute under the Department of Biotechnology, Government of India, and the Oklahoma Medical Research Foundation. The global liver cancer drug market size was valued at US$824 Million in 2020 and is anticipated to grow at a CAGR of 29.4% during forecast period 2021 to 2030. In early pre-clinical investigation Q BioMed's Uttroside-B showed ten times the cytotoxicity against HCC, which is the toxicity caused due to the action of the chemotherapeutic agent on living cancer cells, as compared to the current standard of care drug at the time. Currently, there are only two approved first-line mono therapies and a combination first-line therapy for HCC. Challenges with current treatments include patients becoming resistant to the specific drugs, adverse side effects, and high costs. About Q BioMed Inc. Q BioMed Inc. is a biotech acceleration and commercial stage company focused on licensing and acquiring undervalued biomedical assets in the healthcare sector. Q BioMed provides these target assets the strategic resources, developmental support, and expansion capital needed to ensure they meet their developmental potential, enabling them to provide products to patients in need‏. Please visit and sign up for regular updates. Q BioMed Media Contact: Denis Corin CEO Investor Relations Contact: Landon Capital Keith Pinder (404) 995-6671 [email protected] Forward-Looking Statements: This press release may contain "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Such statements include, but are not limited to, any statements relating to our growth strategy and product development programs and any other statements that are not historical facts. Forward-looking statements are based on management's current expectations and are subject to risks and uncertainties that could negatively affect our business, operating results, financial condition, and stock price. Factors that could cause actual results to differ materially from those currently anticipated are: risks related to our growth strategy; risks relating to the results of research and development activities; our ability to obtain, perform under, and maintain financing and strategic agreements and relationships; uncertainties relating to preclinical and clinical testing; our dependence on third-party suppliers; our ability to attract, integrate, and retain key personnel; the early stage of products under development; our need for substantial additional funds; government regulation; patent and intellectual property matters; competition; as well as other risks described in our SEC filings. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in our expectations or any changes in events, conditions, or circumstances on which any such statement is based, except as required by law. Investor Relations Contact: Landon Capital Keith Pinder (404) 995-6671 [email protected] SOURCE Q BioMed Inc.

孤儿药

2022-10-11

·BioSpace

Q BIOMED PROVIDES SHAREHOLDER UPDATE

Focus on Portfolio Monetization and Roll-up Strategy NEW YORK, Oct. 11, 2022 /PRNewswire/ -- Q Biomed Inc. (OTCQB: QBIO), a commercial stage biotechnology acceleration development company, is pleased to provide an update to its shareholders. The focus for 2022 is to monetize the current pipeline and build a platform for future growth and value creation. To this end, the Company is expecting to amend its current agreement with Mannin research into an equity stake that will add millions of dollars to is asset base. We believe this transaction will not only add real asset value to the balance sheet but with Mannin's near-term catalysts and significant non-dilutive funding commitments, we expect this to grow substantially over the next 6 to 24 months. Mannin's drug platform development program is making solid progress and aims to have a clinical trial in ARDS (acute respiratory disease syndrome) completed in the next 8 months. Data from this trial will support the filings for further indications, including kidney disease and glaucoma. ARDS is only one of three initial indications. Combined, the addressable market for these therapies is over $150 billion a year. We are now also engaged in a strategic roll-up strategy of our future development platform with emphasis on the rare disease space and other areas where no successful treatments are available. This enables us to focus our resources in an area in which we currently have a presence. Our liver cancer drug candidate, Uttroside B, has already received Orphan Drug Designation. We expect to partner or advance this asset toward the clinic in 2022 and will grow our development platform through in-licensing or acquisition as part of a strategic roll-up. We have several new target transactions under this strategy and look forward to updating our shareholders and other stakeholders in the near term. The Company is pleased with the ongoing adoption of Strontium in additional hospital systems and 2022 revenue is far exceeding that of 2021 year to date, capital market conditions are making additional investment into the sales effort challenging. We continue to believe that Strontium89 has great potential in the cancer palliation space. We have planned a top-down marketing and sales program that will be implemented once funded and believe this effort will yield the results we are striving toward. While we believe these corporate activities are building value, we are painfully aware of the dismal performance of our stock. Unfortunately, our cap and debt structure coupled with the general macro-market uncertainty and specifically the biotech market capitulation, has resulted in a valuation for QBIO that is not reflective of the inherent asset value within our portfolio. Our mission continues to be to solve problems by accelerating the development of important therapies and the availability of those therapies to patients. We have been building a portfolio that we believe has significant value ranging from blockbuster potential drugs to revenue-producing opportunities. Since Q BioMed's inception 5 years ago, the Company has brought a product to market, started generating revenue, supported the development of a drug platform that addresses major therapeutic markets and developed a new liver cancer chemotherapeutic previously believed to be impossible to synthesize. We are now focused on monetizing our current portfolio and actively growing our asset value through joint venture and acquisition strategies that will roll-up into a high value asset portfolio addressing multi-billion-dollar markets. Last week we withdrew our registration statement on Form S-1 as we were asked by the Securities and Exchange Commission to do so if we were no longer on planning on executing that transaction. We continue to plan to raise capital to be able to execute but are focused at the moment on realizing a greater valuation through the advancement of our assets and their monetization in the near term. About Q BioMed Inc. Q BioMed Inc is a biotech acceleration and commercial stage company. Q BioMed is focused on licensing and acquiring undervalued biomedical assets in the healthcare sector. Q BioMed is dedicated to providing these target assets the strategic resources, developmental support, and expansion capital needed to ensure they meet their developmental potential, enabling them to provide products to patients in need‏. Please visit and sign up for regular updates. Forward-Looking Statements: This press release may contain "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Such statements include, but are not limited to, any statements relating to our growth strategy and product development programs and any other statements that are not historical facts. Forward-looking statements are based on management's current expectations and are subject to risks and uncertainties that could negatively affect our business, operating results, financial condition and stock price. Factors that could cause actual results to differ materially from those currently anticipated are: risks related to our growth strategy; risks relating to the results of research and development activities; our ability to obtain, perform under and maintain financing and strategic agreements and relationships; uncertainties relating to preclinical and clinical testing; our dependence on third-party suppliers; our ability to attract, integrate, and retain key personnel; the early stage of products under development; our need for substantial additional funds; government regulation; patent and intellectual property matters; competition; as well as other risks described in our SEC filings. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in our expectations or any changes in events, conditions or circumstances on which any such statement is based, except as required by law. Q BioMed Media Contact: Denis Corin CEO Investor Relations - Landon Capital: Keith Pinder +1(404) 995-6671 ir@qbiomed.com Company Codes: OTC-BB:QBIO, OTC-QB:QBIO, OtherOTC:QBIO

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