去甲肾上腺素/普鲁卡因/丙氧卡因(Norepinephrine bitartrate/procaine hydrochloride/propoxycaine hydrochloride) - 药物靶点：Sodium channels x α1A-AR x α1B-AR_专利_临床

概要

基本信息

药物类型

小分子化药

别名

LEVONORDEFRIN/PROCAINE HYDROCHLORIDE/PROPOXYCAINE HYDROCHLORIDE、RAVOCAINE AND NOVOCAIN W/ NEO-COBEFRIN、Ravocaine And Novocain W/Levophed

靶点

Sodium channels x α1A-AR x α1B-AR

作用机制

钠通道阻滞剂、α1A-AR激动剂(肾上腺素能受体α-1a激动剂)、α1B-AR激动剂(肾上腺素能受体α-1b激动剂)

治疗领域-

在研适应症-

非在研适应症-

原研机构

Eastman Kodak Co.

在研机构-

非在研机构

Eastman Kodak Co.

最高研发阶段撤市

首次获批日期

美国 (1952-09-19)

最高研发阶段(中国)-

特殊审评-

登录后查看时间轴

结构

分子式C12H19NO10

InChIKeyLNBCGLZYLJMGKP-LUDZCAPTSA-N

CAS号108341-18-0

查看全部结构式(3)

关联

100 项与去甲肾上腺素/普鲁卡因/丙氧卡因相关的临床结果

登录后查看更多信息

100 项与去甲肾上腺素/普鲁卡因/丙氧卡因相关的转化医学

登录后查看更多信息

100 项与去甲肾上腺素/普鲁卡因/丙氧卡因相关的专利（医药）

登录后查看更多信息

10

项与去甲肾上腺素/普鲁卡因/丙氧卡因相关的文献（医药）

1966-06-01·Oral Surgery, Oral Medicine, Oral Pathology

The relationship of pH to osmotic pressure of local anesthetic solutions at body temperature

Article

作者: Allen Fred Goldberg ; Vincent J. Sawinski ; Raymond J. Loiselle

Mean pH and osmolality of clin. local anesthetic solutions were: 0.4% Ravocaine-2% Novocaine-l:30,000 Levophed, 4.4, 262; 1.5% Primacaine-1:60,000 epinephrine, 4.7, 383; 2% lidocaine 6.1, 309; 2% lidocaine-1:100,000 epinephrine, 4.2, 343; 2% Carbocaine 5.3, 242; and 2% Carbocaine-1: 20,000 Neo-Cobefrin, 3.9, 207.

1958-04-01·Journal of Dental Research2区 · 医学

Some Pharmacologic Properties of Levo- and Dextro-Nordefrin

2区 · 医学

Article

作者: Wessinger, G.D. ; Luduena, F.P. ; Hoppe, James O. ; Oyen, Irene H.

In dogs anesthetized with pentobarbital, l-nordefrin was 100-200 times more active than its d isomer in raising blood pressure.Adrenaline was 2-2.5 times more active than l-nordefrin.In approx. equipressure doses l-nordefrin produced a somewhat greater increase in heart rate than adrenaline but was considerably less active in stimulating the retractor penis.In equipressure doses d-nordefrin produced greater contractions of the retractor penis than its l isomer.On the nonpregnant rat uterus in vitro adrenaline was 15 times more inhibitory than l-nordefrin, and the latter approx. 5000 times more active than its d isomer.The intravenous L.D.₅₀ ± S.E. of l-nordefrin in white mice was 12.6 ± 2.7 mg./kg.; it was 10 times more toxic than the d isomer, and approx. 1/5 as toxic as adrenaline. l-Nordefrin prolonged significantly the duration of local anesthesia.In a solution containing ravocaine-procaine, 1:10,000 racemic nordefrin produced a slightly longer duration than did 1:20,000 l-nordefrin.

1956-10-01·The Guthrie Journal

Ravocaine

Article

作者: BREHN, W F ; NORK, E P

100 项与去甲肾上腺素/普鲁卡因/丙氧卡因相关的药物交易

登录后查看更多信息