Two-year outcomes of different subretinal fluid drainage techniques during vitrectomy for fovea-off rhegmatogenous retinal detachments: ELLIPSOID-2 study

Article

作者: McKay, Bryon R ; Kryshtalskyj, Michael ; Bansal, Aditya ; Berger, Alan R ; Muni, Rajeev H ; Wong, David T

BackgroundThe purpose of the study is to compare visual acuity, complications and outer retinal integrity following subretinal fluid (SRF) drainage from the peripheral retinal breaks (PRBs) versus posterior retinotomy (PR) versus perfluorocarbon liquid (PFCL) for macula-off rhegmatogenous retinal detachments (RRDs) at 2 years post-surgery.MethodsRetrospective analysis of 300 consecutive patients with primary RRD undergoing 23-gauge pars plana vitrectomy with SRF drainage through (1) PRB (n=100), (2) PR (n=100) or (3) with PFCL (n=100). Primary outcomes were visual acuity (best-corrected visual acuity (BCVA)) and complications (cystoid macular oedema (CMO) and epiretinal membrane (ERM)). Secondary outcomes were discontinuity of the external limiting membrane (ELM), ellipsoid zone (EZ) and interdigitation zone (IDZ) at 2 years post-surgery.ResultsMean (±SD) logMAR BCVA at 24 months was better in the PRB compared with PR and PFCL, with PFCL having the worst BCVA (PRB 0.5±0.6; PR 0.7±0.5; PFCL 0.9±0.7, p=0.001). CMO was higher with PFCL (PRB 29.7%; PR 30.2%; PFCL 45.9%, p=0.0015) and ERM formation was higher in PR (PRB 62.6%; PR 93.0%; PFCL 68.9%, p=0.002). There were no differences in ELM or EZ discontinuity. However, IDZ discontinuity was higher in PFCL (PRB 34%; PR 27%; PFCL 46%, p=0.002) at 2 years.ConclusionsVisual acuity was worse and discontinuity of the IDZ and CMO was greater in eyes with PFCL-assisted drainage compared with PRB or PR. Drainage technique may impact long-term visual acuity and photoreceptor integrity.

2024-08-01·International Journal of Biological Macromolecules

Coconut shell-based biochars produced by an innovative thermochemical process for obtaining improved lignocellulose-based adsorbents

Article

作者: Araújo, Rayanne Ferreira ; Fregolente, Laís Gomes ; Moura, Thiago A ; Alves, Sarah Beatriz Salgueiro ; Ferreira, Odair P ; Bezerra, Luiz Carlos Alves ; Vieira, Laís Helena Sousa ; da Silva, Napoleão Evangelista Pereira ; Avelino, Francisco

The urgent need for a simple and cost-effective thermochemical process to produce biochar has prompted this study. The aim was to develop a straightforward thermochemical process under O₂-limited conditions for the production of coconut-based biochar (CBB) and to assess its ability to remove methylene blue (MB) through adsorption, comparing it with CBB produced by slow pyrolysis. CBBs were obtained under different atmospheric conditions (O₂-limited, muffle furnace biochar (MFB); and inert, pyrolytic reactor biochar (PRB)), at 350, 500, and 700 °C, and for 30 and 90'. MFB and PRB were characterized using FTIR, RAMAN, SEM, EDS, and XRD analyses. Adsorption tests were conducted using 1.0 g L^-1 of MFB and PRB, 10 mg L^-1 of MB at 25 °C for 48 h. Characterization revealed that atmospheric conditions significantly influenced the yield and structural features of the materials. PRB exhibited higher yields and larger cavities than MFB, but quite similar spectral features. Adsorption tests indicated that MFB and PRB had q_t values of 33.1 and 9.2 mg g-¹, respectively, which were obtained at 700 °C and 90', and 700 °C and 30', respectively. This alternative method produced an innovative and promising lignocellulose-based material with great potential to be used as a biosorbent.

2024-06-01·Probiotics and Antimicrobial Proteins

Electrospun Fibers Loaded with Probiotics: Fundamentals, Characterization, and Applications

Review

作者: Assadpour, Elham ; Rastegar, Hossein ; Gharavi-Nakhjavani, Maryam ; Mohseni, Mehran ; Alizadeh, Adel Mirza ; Hashempour-Baltork, Fataneh ; Jafari, Seid Mahdi ; Aminzare, Majid ; Gerami, Kosar

Increasing demand for safe, efficient, and eco-friendly solutions for pharmaceutical and food industries has led researchers to explore new approaches to bacterial storage. Several advantages make electrospinning (ES) a promising technique for food systems, including simple manufacturing equipment, a relatively low spinning cost, a wide variety of spinnable materials, and a mild process that is easily controlled, which allows continuous fabrication of ultrafine polymeric fibers at submicron or nanoscales without high temperatures or high pressures. This review briefly describes recent advances in the development of electrospun fibers for loading probiotics (PRB) by focusing on ES technology, its efficiency for loading PRB into fibers (viability, digestive stability, growth rate, release, thermal stability, and interactions of fibers with PRB), and the application of PRB-loaded fibers as active packaging (spoilage/microbial control, antioxidant effect, shelf life). Based on the literature reviewed, the incorporation of PRB into electrospun fibers is both feasible and functional. However, several studies have been limited to proof-of-principle experiments and the use of model biological products. It is necessary to conduct further research to establish the industrial applicability of PRB-loaded fibers, particularly in the fields of food and medicine.

100 项与 PRB-2 相关的药物交易

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适应症	最高研发状态	国家/地区	公司	日期
心血管疾病	药物发现	挪威	Pronova BioPharma ASA	-
炎症	药物发现	挪威	Pronova BioPharma ASA	-
代谢性疾病	药物发现	挪威	Pronova BioPharma ASA	-