A Clinical Study to Evaluate the Safety, Tolerability and Initial Efficacy of Targeted Haploidentical Neoantigen T Cell Injection (hNeo-T) in the Treatment of Relapsed or Refractory EBV-positive T-cell Lymphoma

Objective: To evaluate the safety and tolerability of hNeo-T injection in patients with relapsed or refractory EBV-positive T-cell lymphoma.
Secondary objective: To evaluate the effectiveness of hNeo-T injection, and to evaluate the objective response rate (ORR) and disease control rate (DCR) by Lugano2014 criteria; Progression-free survival (PFS), duration of response (DOR), and overall survival (OS ) followed.
Objective of the exploratory study: To investigate the in vivo process of hNeo-T injection and describe the activity and related biological functions of hNeo-T cells in vivo, including but not limited to.

开始日期2023-12-01

申办/合作机构

深圳华大基因股份有限公司

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100 项与 Targeted Neoantigen Haploidentical T Cell Injection(BGI Genomics) 相关的临床结果

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100 项与 Targeted Neoantigen Haploidentical T Cell Injection(BGI Genomics) 相关的转化医学

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100 项与 Targeted Neoantigen Haploidentical T Cell Injection(BGI Genomics) 相关的专利（医药）

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项与 Targeted Neoantigen Haploidentical T Cell Injection(BGI Genomics) 相关的文献（医药）

2024-06-01·International Journal of Biological Macromolecules

Fabrication and characterization of physically crosslinked alginate/chitosan-based hydrogel loaded with neomycin for the treatment of skin infections caused by Staphylococcus aureus

Article

作者: Sousa, Carlos Eduardo Morais de ; Silva, Lucas Dos Santos ; Vila Nova, Beatriz Gomes ; Silva, Izadora Souza Soeiro ; Teixeira, Claudener Souza ; Tofanello, Aryane ; Nascimento da Silva, Luís Cláudio ; Silva, Raphael Guedes ; Garcia, Wanius ; Carvalho, Layse Ribeiro de Sousa ; Monteiro, Cristina de Andrade ; Cardenas, Andres Felipe Millan ; Moreira, Pedro Henrique de Aguiar

Staphylococcus aureus is a pathogen widely involved in wound infection due to its ability to release several virulence factors that impair the skin healing process, as well as its mechanism of drug resistance. Herein, sodium alginate and chitosan were combined to produce a hydrogel for topical delivery of neomycin to combat S. aureus associated with skin complications. The hydrogel was formulated by combining sodium alginate (50 mg/mL) and chitosan (50 mg/mL) solutions in a ratio of 9:1 (HBase). Neomycin was added to HBase to achieve a concentration of 0.4 mg/mL (HNeo). The incorporation of neomycin into the product was confirmed by scanning electron microscopy, FTIR and TGA analysis. The hydrogels produced are homogeneous, have a high swelling capacity, and show biocompatibility using erythrocytes and fibroblasts as models. The formulations showed physicochemical and pharmacological stability for 60 days at 4 ± 2 °C. HNeo totally inhibited the growth of S. aureus after 4 h. The antimicrobial effects were confirmed using ex vivo (porcine skin) and in vivo (murine) wound infection models. Furthermore, the HNeo-treated mice showed lower severity scores than those treated with HBase. Taken together, the obtained results present a new low-cost bioproduct with promising applications in treating infected wounds.

100 项与 Targeted Neoantigen Haploidentical T Cell Injection(BGI Genomics) 相关的药物交易

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