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更新于：2025-05-07

Cryptenamine Acetates

更新于：2025-05-07

概要

概要

基本信息

药物类型

小分子化药

别名

Unitensen

靶点-

作用方式-

作用机制-

治疗领域-

在研适应症-

非在研适应症-

原研机构

Parke-Davis & Co. Ltd.

在研机构-

非在研机构

Parke-Davis & Co. Ltd.

权益机构-

最高研发阶段撤市

首次获批日期

美国 (1982-01-01)

最高研发阶段(中国)-

特殊审评-

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关联

100 项与 Cryptenamine Acetates 相关的临床结果

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100 项与 Cryptenamine Acetates 相关的转化医学

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100 项与 Cryptenamine Acetates 相关的专利（医药）

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项与 Cryptenamine Acetates 相关的文献（医药）

1975-01-01·Journal of Surgical Research4区 · 医学

Evaluation of various hypotensive agents in the control of experimental hemorrhage

4区 · 医学

Article

作者: Gerald W. Shaftan ; Horace Herbsman ; John C. Powers

Of 10 hypotensive drugs tested for control of exptl. hemorrhage in dogs, phenoxybenzamine-HCl (I) [63-92-3] (10 ml/kg, i.v.), cryptenamine acetate [55963-37-6] (i.v. infusion), diazoxide [364-98-7] (300 mg, i.v.) and nitroprusside Na [14402-89-2] (i.v. infusion) were the most effective.It appears that any drug which will produce satisfactory hypotension is potentially useful in the control of hemorrhage.

1971-04-01·American Journal of Obstetrics and Gynecology1区 · 医学

Modification of the generalized Shwartzman reaction by therapeutic agents

1区 · 医学

Article

作者: Donald G. McKay ; Kenji Nasu ; Jean G. Latour

Various therapeutic agents known to produce vasodilation diminished the deposition of fibrin in the renal glomeruli of rabbits following exposure to bacterial endotoxin (Shwartzman reaction).Hexamethonium chloride (I) was most effective, followed by cryptenamine acetate and Mg++ and K+.

1969-09-01·American Journal of Obstetrics and Gynecology1区 · 医学

Effect of toxemia therapy on uterine dynamics

1区 · 医学

Article

作者: George W. Cornell ; W.Norman Thornton ; Guy M. Harbert

Abstract Effect on uterine dynamics of magnesium sulfate, hydralazine hydrochloride, and cryptenamine acetates was evaluated by in vitro and in vivo techniques. Magnesium sulfate depressed myometrial activity in vitro. Hydralazine hydrochloride decreased the rate and increased the amplitude of contraction of human myometrial strips. In concentrations of 6 to 8 mEq. per liter of maternal serum, magnesium reduced the uterine activity of 7 pre-eclamptic patients in active spontaneous labor. The effect of each agent on myometrial and hemodynamic variables was measured in 3 pregnant rhesus monkeys during both normotensive and induced hypertensive states. Serum magnesium concentrations of 6 to 8 mEq. per liter resulted in a reduction of arterial blood pressure, a greater decrease in extrinsic myometrial resistance, and an increase in uterine artery blood flow. Intravenous administration of hydralazine hydrochloride in quantities sufficient to produce a statistically significant decrease in arterial blood pressure did not significantly alter uterine artery blood flow or average intra-amniotic pressure. Responses to cryptenamine acetates were inconclusive.

100 项与 Cryptenamine Acetates 相关的药物交易

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