A-42867(A-42867) - _专利_临床

概要

基本信息

药物类型

合成多肽

别名

靶点-

作用机制

细胞壁抑制剂

治疗领域

感染

在研适应症-

非在研适应症

细菌感染

原研机构

Biosearch Italia SpA

在研机构-

非在研机构

Biosearch Italia SpA

最高研发阶段终止临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 A-42867 相关的临床结果

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100 项与 A-42867 相关的转化医学

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100 项与 A-42867 相关的专利（医药）

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1

项与 A-42867 相关的文献（医药）

1989-01-01·The Journal of Antibiotics4区 · 医学

A42867, a novel glycopeptide antibiotic.

4区 · 医学

Article

作者: M. Denaro ; E. Riva ; E. Selva ; F. Parenti ; G. Cassani ; M. Berti ; B. P. Goldstein ; L. Gastaldo ; P. Ferrari ; M. G. Beretta ; L. F. Zerilli

A42867 is a new glycopeptide antibiotic of the ristocetin-vancomycin class active against aerobic and anaerobic Gram-positive bacteria. A42867 is produced by a strain of Nocardia nov. sp. ATCC 53492. A42867 was isolated during a screening program aimed at the discovery of new members of this glycopeptide class of antibiotics, by affinity chromatography based on an acyl-D-alanyl-D-alanine probe. The structure of A42867 was elucidated by fast atom bombardment MS, high field 2D 1H NMR spectroscopy, and HPLC analysis of the hydrolyzed carbohydrates. A42867 differs from vancomycin in the sugar portion and in the presence of only one chlorine atom in the peptide core. Its biological activity on Gram-positive aerobic and anaerobic bacteria is similar to that of other antibiotics of this group.

100 项与 A-42867 相关的药物交易

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