AMI-DC (Pharos Vaccine)(AMI-DC (Pharos Vaccine)) - 在研适应症：心脏衰竭_专利_临床

概要

基本信息

药物类型

细胞疗法

别名-

靶点-

作用机制-

治疗领域

心血管疾病

在研适应症

心脏衰竭

非在研适应症-

原研机构

Pharos Vaccine, Inc.

在研机构

Pharos Vaccine, Inc.

非在研机构-

最高研发阶段临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

登录后查看时间轴

关联

100 项与 AMI-DC (Pharos Vaccine) 相关的临床结果

登录后查看更多信息

100 项与 AMI-DC (Pharos Vaccine) 相关的转化医学

登录后查看更多信息

100 项与 AMI-DC (Pharos Vaccine) 相关的专利（医药）

登录后查看更多信息

1

项与 AMI-DC (Pharos Vaccine) 相关的文献（医药）

Journal of Agricultural and Food Chemistry

Regulatory Effect of Transcriptional Regulator TetR on the Synthesis of Conjugated Linoleic Acid in Lactiplantibacillus plantarum AR195

Article

作者: Xiong, Zhi-Qiang ; Dou, Hui ; Liu, Lei ; Liu, Xin-Xin ; Ai, Lian-Zhong ; Wang, Guang-Qiang

Conjugated linoleic acid (CLA) possesses anticancer, anti-inflammatory, and antiobesity properties, making it a significant research focus. In this study, we identified TetR, a TetR/AcrR family transcriptional regulator encoded by AR1031, as the transcriptional regulator of CLA synthesis in Lactiplantibacillus plantarum AR195. TetR binds to the promoter regions of the CLA synthesis genes, including the cla operon and cla-hy, thereby enhancing CLA biosynthesis. Knockout of tetR led to the downregulation of cla-hy by 68%, cla-dh by 86%, and cla-dc by 33%, resulting in reduced CLA yield. Further bioinformatic analysis and segmented electrophoretic mobility shift assay (EMSA) experiments revealed that TetR recognizes a conserved sequence (5'-TGTAGATTG-n₄-CTTCA-3') and binds to multiple sites within the regulatory region of the cla operon and cla-hy, thus promoting CLA biosynthesis. Overexpression of tetR increased the CLA yield by 7%. These findings provide precise insights into the regulation of CLA biosynthesis and suggest strategies for enhancing CLA production.

100 项与 AMI-DC (Pharos Vaccine) 相关的药物交易

登录后查看更多信息