CD4M33(CD4M33) - 药物靶点：CD4 x ITIH4_在研适应症：HIV感染_专利_临床

概要

基本信息

药物类型

合成多肽

别名

靶点

CD4 x ITIH4

作用机制

CD4调节剂(T细胞表面抗原CD4调节剂)、gp120抑制剂(inter-alpha-trypsin inhibitor heavy chain 4 inhibitors)

治疗领域

免疫系统疾病感染泌尿生殖系统疾病

在研适应症

HIV感染

非在研适应症-

原研机构

Comité de lénergie Atomique

在研机构

Comité de lénergie Atomique

非在研机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

序列信息

Sequence Code 530929744

关联

100 项与 CD4M33 相关的临床结果

登录后查看更多信息

100 项与 CD4M33 相关的转化医学

登录后查看更多信息

100 项与 CD4M33 相关的专利（医药）

登录后查看更多信息

1

项与 CD4M33 相关的文献（医药）

2003-01-01·Nature biotechnology

Rational design of a CD4 mimic that inhibits HIV-1 entry and exposes cryptic neutralization epitopes.

Article

作者: Magne, Xavier ; Missé, Dorothée ; Roumestand, Christian ; Stricher, François ; Pugnière, Martine ; Ménez, André ; Lusso, Paolo ; Veas, Francisco ; Martin, Loïc ; Barthe, Philippe ; Prado-Gotor, Rafael ; Sironi, Francesca ; Freulon, Isabelle ; Vita, Claudio

The conserved surfaces of the human immunodeficiency virus (HIV)-1 envelope involved in receptor binding represent potential targets for the development of entry inhibitors and neutralizing antibodies. Using structural information on a CD4-gp120-17b antibody complex, we have designed a 27-amino acid CD4 mimic, CD4M33, that presents optimal interactions with gp120 and binds to viral particles and diverse HIV-1 envelopes with CD4-like affinity. This mini-CD4 inhibits infection of both immortalized and primary cells by HIV-1, including primary patient isolates that are generally resistant to inhibition by soluble CD4. Furthermore, CD4M33 possesses functional properties of CD4, including the ability to unmask conserved neutralization epitopes of gp120 that are cryptic on the unbound glycoprotein. CD4M33 is a prototype of inhibitors of HIV-1 entry and, in complex with envelope proteins, a potential component of vaccine formulations, or a molecular target in phage display technology to develop broad-spectrum neutralizing antibodies.

100 项与 CD4M33 相关的药物交易

登录后查看更多信息