精蛋白重组人胰岛素 (深圳科兴生物工程)(Isophane Protamine Recombinant Human Insulin Injection(Shenzhen Kexing Biotech Co. Ltd.))

概要

基本信息

药物类型

生物类似药、激素

别名

Isophane Protamine Recombinant Human Insulin、精蛋白重组人胰岛素注射液（深圳科兴）、苏泌啉恩

靶点

INSR

作用机制

INSR激动剂(胰岛素受体激动剂)

治疗领域

内分泌与代谢疾病

在研适应症

糖尿病

非在研适应症-

原研机构

深圳科兴生物工程有限公司

在研机构

北京亚东生物制药（安国）有限公司

非在研机构-

最高研发阶段批准上市

首次获批日期

中国 (2003-02-24),

糖尿病

最高研发阶段(中国)批准上市

特殊审评-

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序列信息

Sequence Code 4868

Sequence Code 4857

关联

100 项与精蛋白重组人胰岛素 (深圳科兴生物工程) 相关的临床结果

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100 项与精蛋白重组人胰岛素 (深圳科兴生物工程) 相关的转化医学

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100 项与精蛋白重组人胰岛素 (深圳科兴生物工程) 相关的专利（医药）

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1

项与精蛋白重组人胰岛素 (深圳科兴生物工程) 相关的文献（医药）

2015-01-01·Endocrinology and Metabolism3区 · 医学

Two Cases of Allergy to Insulin in Gestational Diabetes

3区 · 医学

ArticleOA

作者: Jo, Seong Il ; Kim, Gi Jun ; Lee, Seong Su ; Shin, Jin Kyeong ; Kim, Shin Bum ; Kim, Byung Kee ; Son, Jang Won ; Yoo, Soon Jib ; Jeong, Heekyung ; Kwon, Hee Sun ; Kim, Sung Rae

Allergic reaction to insulin is uncommon since the introduction of human recombinant insulin preparations and is more rare in pregnant than non-pregnant females due to altered immune reaction during pregnancy. Herein, we report two cases of allergic reaction to insulin in gestational diabetes that were successfully managed. One case was a 33-year-old female using isophane-neutral protamine Hagedorn human insulin and insulin lispro. She experienced dyspnea, cough, urticaria and itching sensation at the sites of insulin injection immediately after insulin administration. We discontinued insulin therapy and started oral hypoglycemic agents with metformin and glibenclamide. The other case was a 32-year-old female using insulin lispro and insulin detemer. She experienced pruritus and burning sensation and multiple nodules at the sites of insulin injection. We changed the insulin from insulin lispro to insulin aspart. Assessments including immunoglobulin E (IgE), IgG, eosinophil, insulin antibody level and skin biopsy were performed. In the two cases, the symptoms were resolved after changing the insulin to oral agents or other insulin preparations. We report two cases of allergic reaction to human insulin in gestational diabetes due to its rarity.

100 项与精蛋白重组人胰岛素 (深圳科兴生物工程) 相关的药物交易

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