莫米松糠酸酯/水杨酸(Mometasone furoate/Salicylic acid) - 药物靶点：COX x GR_在研适应症：皮肤疾病_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Combisor、Mometasone/salicylic acid、Monsalic

+ [2]

靶点

COX x GR

作用机制

COX抑制剂(环氧化酶抑制剂)、GR激动剂(糖皮质激素受体激动剂)

治疗领域

皮肤和肌肉骨骼疾病

在研适应症

皮肤疾病

非在研适应症-

原研机构

Merck Sharp & Dohme Corp.

在研机构

Merck GmbH

非在研机构-

最高研发阶段批准上市

首次获批日期

葡萄牙 (2011-08-04),

皮肤疾病

最高研发阶段(中国)-

特殊审评-

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结构

分子式C27H30Cl2O6

InChIKeyWOFMFGQZHJDGCX-ZULDAHANSA-N

CAS号83919-23-7

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关联

2

项与莫米松糠酸酯/水杨酸相关的临床试验

NCT01229085 / Completed临床3期

CLINICAL ASSESSMENT OF THE EFFECTIVENESS OF ASSOCIATION MONETASONE FUROATE 0.1% SALICYLIC ACID AND 5% FOR SUBMISSION OF OINTMENT TOPICAL DERMATOLOGICAL USE OF LABORATORY Glenmark Pharmaceuticals Ltd, IN PATIENTS WITH PSORIASIS.

To evaluate the efficacy of the combination of mometasone furoate 0.1% and Salicylic Acid 5% in patients of both sexes who presented clinical symptoms of psoriasis of mild to moderate.

开始日期2006-09-01

申办/合作机构

Azidus Brasil

NCT01228656 / Suspended临床2期

CLINICAL EVALUATION OF EFFECTIVENESS OF ASSOCIATION MOMETASONE FUROATE 0.1% AND SALICYLIC ACID 5% COMPARED WITH 0.1% MOMETASONE FUROATE INSULATED TOPICAL USE OF LABORATORY Glenmark Pharmaceuticals Ltd, IN PATIENTS WITH PSORIASIS IN PLATE

The aims is to evaluate the efficacy and comparative isolation of the association Mometasone furoate + Salicylic Acid and the substance isolated Mometasone furoate produced by the Laboratory Glenmark Pharmaceuticals Ltd. in patients of both sexes, patients with plaque psoriasis grade mild to moderate.

开始日期2006-09-01

申办/合作机构

Azidus Brasil

100 项与莫米松糠酸酯/水杨酸相关的临床结果

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100 项与莫米松糠酸酯/水杨酸相关的转化医学

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100 项与莫米松糠酸酯/水杨酸相关的专利（医药）

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3

项与莫米松糠酸酯/水杨酸相关的文献（医药）

1998-03-01·Steroids

An Unusual Dienone-Phenol Rearrangement Product Formed During the Aynthesis of Mometasone Furoate (Sch 32088) 11Tables of atomic positional and thermal parameters, bond lengths and angles for compound 4 have been deposited at the Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK.

Article

作者: Richard W. Draper ; Andrew T. McPhail ; Eugene J. Vater ; Mohindar S. Puar

The structure of an unusual dienone-phenol rearrangement product 4 obtained during the synthesis of mometasone furoate (Sch 32088) was assigned on the basis of NMR and x-ray crystallographic data. The mechanism of formation is discussed.

1995-09-01·Steroids4区 · 医学

An unusual rearrangement product formed during production of mometasone furoate (Sch 32088)

4区 · 医学

Article

作者: D. Beiner ; M.S. Puar ; M. Ruggeri ; A.T. McPhail ; P.A. Thompson

The structure of an unusual rearrangement product obtained during the production of mometasone furoate (Sch 32088) was assigned on the basis of NMR and X-ray crystallography data.

1992-07-01·Journal of Pharmaceutical and Biomedical Analysis3区 · 医学

A competitive enzyme immunoassay for the direct determination of mometasone furoate (SCH 32088) in human plasma

3区 · 医学

Article

作者: Kevin Byrnes ; Zuguang Tian ; Chang-Jin Wang ; Chin-Chung Lin

Mometasone furoate (SCH 32088) is a synthetic corticosteroid which has a topical anti-inflammatory activity with a minimal potential for suppressing hypothalamic-pituitary-adrenocortical (HPA) axis. A sensitive competitive enzyme immunoassay (EIA) for measuring SCH 32088 in unextracted human plasma has been developed. The 3-(O-carboxymethyl)oxime (CMO) of SCH 32088 was synthesized and conjugated with bovine thyroglobulin, and the product was used for the production of antibodies in rabbits. SCH 32088-3-CMO was also conjugated with horseradish peroxidase, which was used as the tracer. The EIA thus developed can detect 1 pg SCH 32088 per assay or 25 pg per ml of human plasma. It can reliably quantitate SCH 32088 in human plasma from 50 pg ml-1 to 2.5 ng ml-1 with good linearity, accuracy and precision. The assay can be extended to measure SCH 32088 in plasma of laboratory animals. The availability of this sensitive assay makes it possible to evaluate the pharmacokinetics and toxicokinetics of SCH 32088 in laboratory animals and man.

100 项与莫米松糠酸酯/水杨酸相关的药物交易

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