NP-0336(NP-0336) - 药物靶点：Cholinesterase_专利_临床

概要

基本信息

药物类型

小分子化药

别名

靶点

Cholinesterase

作用机制

胆碱酯酶抑制剂

治疗领域

其他疾病

在研适应症-

非在研适应症

认知障碍

原研机构

Noscira SA

在研机构-

非在研机构

Noscira SA

最高研发阶段无进展药物发现

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 NP-0336 相关的临床结果

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100 项与 NP-0336 相关的转化医学

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100 项与 NP-0336 相关的专利（医药）

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1

项与 NP-0336 相关的文献（医药）

2008-08-15·Journal of Virology2区 · 医学

A Simple Mathematical Model Helps To Explain the Immunodominance of CD8 T Cells in Influenza A Virus Infections

2区 · 医学

Article

作者: Handel, Andreas ; Antia, Rustom

ABSTRACT Understanding immunodominance, the phenomenon of epitope-specific T cells expanding in an often distinctly hierarchical fashion, is important for the design of T-cell-based intervention strategies. Several recent studies have investigated immunodominance of H-2D b -restricted CD8 + T cells specific for the nucleoprotein NP366 and acid polymerase PA224 epitopes during influenza A virus infection of C57BL/6 mice. CD8 + T cells specific for these two epitopes are codominant during primary infection; NP366 dominates during secondary infection. While a number of explanations for this observation have been proposed, none of them can fully account for all the observed data. In this article, we use a simple mathematical model to explain the seemingly inconsistent data. We show that the dynamic interactions between CD8 + T cells and antigen presentation lead to a situation where CD8 + T cells are limiting during the initial response whereas antigen is limiting in the secondary response. This “numbers game” between antigen and CD8 + T cells can reproduce the observed immunodominance of the NP336- and PA224-specific CD8 + T cells, thereby explaining the reported experimental data.

100 项与 NP-0336 相关的药物交易

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