Clovibactin(Clovibactin) - 药物靶点：Peptidoglycan_在研适应症：细菌感染_专利_临床

概要

基本信息

药物类型

小分子化药

别名-

靶点

Peptidoglycan

作用机制

肽聚糖抑制剂

治疗领域

感染

在研适应症

细菌感染

非在研适应症-

原研机构

University of Utrecht

在研机构

University of Utrecht

非在研机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 Clovibactin 相关的临床结果

登录后查看更多信息

100 项与 Clovibactin 相关的转化医学

登录后查看更多信息

100 项与 Clovibactin 相关的专利（医药）

登录后查看更多信息

4

项与 Clovibactin 相关的文献（医药）

2024-10-04·The Journal of Organic Chemistry

Correction to “Structure–Activity Relationship Studies of the Peptide Antibiotic Clovibactin”

作者: Nowick, James S. ; Griffin, James H ; Brunicardi, Jackson E H ; Mendoza, Ana-Teresa ; Ferracane, Michael J ; Brunicardi, Jackson E. H. ; Kreutzer, Adam G ; Ziller, Joseph W. ; Griffin, James H. ; Ferracane, Michael J. ; Ziller, Joseph W ; Kreutzer, Adam G. ; Small, Jeramiah ; Nowick, James S

2024-09-06·The Journal of Organic Chemistry

Structure–Activity Relationship Studies of the Peptide Antibiotic Clovibactin

Article

作者: Nowick, James S. ; Griffin, James H. ; Small, Jeramiah ; Ferracane, Michael J. ; Mendoza, Ana-Teresa ; Brunicardi, Jackson E. H. ; Kreutzer, Adam G. ; Ziller, Joseph W.

2024-08-01·Allergy

Clovibactin: Discovery and antimicrobial mechanism of action

作者: Paris, Juan L. ; Torres, Pablo ; Pérez‐Moreno, Ana M.

A review.The rise of antibiotic resistance constitutes an important threat for human health globally.Thus, the quest for antimicrobial agents with novel mechanisms of action is criticalIn this context, Shukla et al. have recently reported a novel antibiotic mol. produced by previously uncultured Gram-neg. soil bacteria from the genus Eleftheria (with an isolate referred to as E. terrae ssp carolina): clovibactin (Figure 1).By a combination of high-performance liquid chromatog. (HPLC), mass spectrometry and NMR (NMR), clovibactin was purified and characterized; and it was determined to be a depsipeptide, consisting in a short linear N terminus hydrophilic peptide (with four amino acid residues) and a hydrophobic macrocyclic lactone or depsicycle (with four amino-acid residues).

100 项与 Clovibactin 相关的药物交易

登录后查看更多信息