The oxidative dissolution of arsenopyrite (FeAsS) is a significant source of arsenic contamination in nature. Activated biochar (AC), a widely used environmental remediation agent, is prevalent in ecosystems and participated in various geochemical processes of arsenic and iron-containing sulfide minerals. However, the impact of AC-arsenopyrite association on reactive oxidation species (ROS) generation and its contribution to As transformation were rarely explored. Here, ROS formation and the redox conversion of As during the interaction between AC and arsenopyrite were investigated. AC-mediated arsenopyrite oxidation was a two-stage process. At stage I, the heterogeneous electron transfer from arsenopyrite facilitated O₂ reduction on AC, enhancing arsenopyrite dissolution and ROS formation. TBA, PBQ and catalase inhibited 86.40 %, 79.39 % and 49.66 % of As(III) oxidation, respectively, indicating indicated that HO˙, (O₂^•)^- and H₂O₂ were responsible for As(III) oxidation. However, at stage II, the mobility of As was highly restricted, especially increasing AC addition. Besides adsorption, AC retained appreciable As through catalyzing insoluble ferric arsenate formation and growth by promoting Fe(II) and As(III) oxidation and functioning as nuclei. These findings deepen our understanding of the coupling behavior of AC-arsenopyrite and its influence on geochemical cycling of arsenic in mined surroundings, which has important implications for mitigating arsenic pollution.

2024-11-01·Animal Reproduction Science

Inhibition of testicular development by suppressing neonatal LH rise in male domestic pigs

Article

作者: Lin, Po-Ching ; Hess, Rex A ; Soto-Heras, Sandra ; Bunnell, Mary ; Chai, Katie ; de França, Luiz Renato ; Oh, Ji-Eun ; Hess, Rex A. ; Park, ChanJin ; Zhou, Sherry ; Ko, CheMyong ; Reinacher, Lindsey

The neonatal increase in circulating luteinizing hormone (LH) is crucial for testicular development. In male pigs, blood LH levels start to increase approximately 1 week after birth and return to basal level by 5-6 weeks of age. This study tested the hypothesis that neonatal treatment with a combination of estrogens and androgens suppresses LH secretion and thereby inhibits testicular development. On Day 1 after birth, piglets received a slow-release implant containing estradiol (E₂, 8-40 mg) and trenbolone acetate (TBA, 40-200 mg) or remained intact. At 4 weeks of age, mean serum LH concentrations were ∼ 7 ng/mL in untreated males, whereas pigs with implants had serum LH concentrations < 1 ng/mL. Despite this reduction, LH was still detected in the pituitary glands of treated pigs. Interestingly, neonatal castration also lowered circulating LH, highlighting the importance of testis physiology in the early establishment of the reproductive axis. The higher dose (20 mg E2 + 100 mg TBA) inhibited testis function more effectively, as evidenced by lower circulating testosterone concentrations compared to intact pigs. Furthermore, E2 + TBA treatment had a lasting impact on testicular growth, resulting in smaller testes at 26 weeks of age and the presence of immature Leydig cells. Overall, neonatal E2 + TBA treatment suppressed the postnatal LH rise and testicular growth until market age, offering a potential non-surgical alternative to castration in male pigs.

2024-10-01·Cirugía Española (English Edition)

Total bile acid as a preoperative risk factor for post-hepatectomy liver failure in patients with hepatocellular carcinoma and normal bilirubin

Article

作者: Liu, Zhenwen ; Li, Zhijie ; Li, Lixin ; Ren, Hui ; Niu, Xiaofeng ; Zhang, Dali ; He, Xi ; Zhang, Xiaofeng

BACKGROUND AND AIMSTotal bile acid (TBA) is associated with portal hypertension, a risk factor for post-hepatectomy liver failure (PHLF). We conducted this study to clarify whether TBA is also associated with PHLF in patients with hepatocellular carcinoma (HCC).METHODSWe recruited patients with HCC and Child-Pugh class A, who underwent liver resection, and applied multivariate analyses to identify risk factors for PHLF.RESULTSWe analyzed data from 154 patients. The prevalence of PHLF was 14.3%. The median maximum tumor diameter was 5.1 cm (2.9-6.9 cm). The proportions of patients with elevated TBA levels (P = 0.001), severe albumin-bilirubin (AIBL) grades (P = 0.033), and low platelet counts (P = 0.031) were significantly higher within the subgroup of patients with PHLF than in the subgroup without PHLF. The multivariate analysis results suggest that TBA level (OR, 1.08; 951.03-1.14; P = 0.003) and MRI tumor diameter (OR, 1.17; 95% CI, 1.01-1.35; P = 0.038) are independent preoperative risk factors for PHLF. The TBA levels correlated with the indocyanine green retention rate at 15 minutes (P = 0.001) and the effective hepatic blood flow (P < 0.001), two markers of portal hypertension. However, TBA levels did not correlate with tumor diameter (P = 0.536).CONCLUSIONSCompared to ICG R15 and AIBL score, preoperative TBA was risk factor for PHLF in Chinese patients with HCC, and it may impact PHLF through its potential role as a marker of portal hypertension.

100 项与 TBA 相关的药物交易

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