The biotransformation of hydrocortisone (1) by Fusarium solani and Aspergillus ochraceus was investigated for the first time. After 10 days at 30 °C, just one metabolite was produced by both fungi: 11β, 17α, 20β, 21-tetrahydroxypregn-4-en-3-one (2) established on the basis of spectroscopic data. The reaction was reduction of the 20-carbonyl group. Time course study determined by HPLC showed 60 and 45 % yield for the metabolite by F. solani and A. ochraceus, respectively.

1971-11-01·The Journal of Clinical Endocrinology & Metabolism2区 · 医学

Studies on Tryptophan Metabolism in Male Subjects Treated with Hydrocortisone¹

2区 · 医学

Article

作者: Raymond R. Brown ; Hans Wolf

The induction of liver tryptophan pyrrolase activity by hydrocortisone sodium succinate (I sodium succinate) [125-04-2] resulted in a flow of L-tryptophan (II) [73-22-3] along the kynurenine pathway that exceeded the normal kynureninase activity when a loading dose of 2 g II was given to male subjects.On the other hand, I seemed to inhibit the extent to which II entered the NAD pathway.Pyridoxine-HCl [58-56-0] supplementation normalized urinary excretion of II metabolites and caused an increase in the urinary excretion of anthranilic acid metabolites.

1955-02-01·Endocrinology2区 · 医学

BLOOD ACTH IN THE STRESSED ADRENALECTOMIZED RAT AFTER INTRAVENOUS INJECTION OF HYDROCORTISONE¹

2区 · 医学

Article

作者: BROWN, DONA ; SYDNOR, KATHERINE L. ; BURKS, ROSALIE

THE experiments of Ingle et al. (1937, 1938), Sayers and Sayers (1945, 1947), Gray and Munson (1951) and Abelson and Baron (1952) have clearly demonstrated that the secretory products of the adrenal cortex inhibit ACTH release in the intact rat. Alterations in the rate of secretion of ACTH were based on changes in weight or the concentration of ascorbic acid of the adrenal glands of the test animal. These indices limit the evaluation of pituitary control since the response in the target gland is measured hours or days after steroid administration. The development of a technic for measuring ACTH in blood has made it possible to study ACTH release in the adrenalectomized animal within a few minutes after administration of hydrocortisone. methods Male rats from the Holtzman Rolfsmeyer farm weighing 250 to 350 gm. were acclimatized for two weeks in our laboratory (constant lighting and temperature, 78 ± 1° F.).

100 项与 PP-210 相关的药物交易

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