过氧化碳酰胺(Carbamide Peroxide) - 在研适应症：胎儿窘迫_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Carbamide peroxide (USP)、Hydrogen peroxide carbamide、Urea dioxide

+ [3]

靶点-

作用机制-

治疗领域

在研适应症

非在研适应症

原研机构

在研机构

非在研机构

最高研发阶段批准上市

首次获批日期-

最高研发阶段(中国)批准上市

特殊审评-

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结构

分子式CH6N2O3

InChIKeyAQLJVWUFPCUVLO-UHFFFAOYSA-N

CAS号124-43-6

关联

14

项与过氧化碳酰胺相关的临床试验

RBR-44k3f3x / Not yet recruiting临床4期IIT

Assessment of bleaching efficacy using two concentrations of carbamide peroxide in home bleaching in adolescents: double-blind randomized clinical trial

开始日期2024-09-02

申办/合作机构

Universidade Estadual de Ponta Grossa

[+1]

CTRI/2024/03/064772 / Active, not recruiting临床2期IIT

Comparative Evaluation of Effectiveness of At-Home Dental Bleaching Using Different Concentrations Of Carbamide Peroxide for Different Time Intervals: A Randomized Clinical Trial - NIL

开始日期2024-04-02

申办/合作机构-

ACTRN12623000547640 / Completed临床3期IIT

Evaluating the effect of age on effectiveness, gingival irritation, and sensitivity following at home bleaching using 10% carbamide peroxide 2 hours a day for 3 weeks.

开始日期2023-10-01

申办/合作机构-

100 项与过氧化碳酰胺相关的临床结果

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100 项与过氧化碳酰胺相关的转化医学

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100 项与过氧化碳酰胺相关的专利（医药）

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986

项与过氧化碳酰胺相关的文献（医药）

2024-10-01·Histology and histopathology

Biological action of bleaching agents on tooth structure: A review.

Review

作者: Aragão, Walessa Alana Bragança ; Lima, Rafael Rodrigues ; Chemelo, Victória Santos ; Silva, Cecy Martins ; Reis, Alessandra ; Pessanha, Sofia ; Alencar, Cristiane de Melo ; Souza-Rodrigues, Renata Duarte

The use of bleaching agents to remove stains is one of the main dental procedures to improve the aesthetics of teeth. This review presents the main agents used for tooth whitening, existing clinical protocols, and the structural changes that may occur through their use. The main bleaching agents consist of hydrogen peroxide and carbamide peroxide, which are used in bleaching techniques for vital teeth. These techniques can be performed in the office by a professional or by the individual in a home en-vironment under professional guidance. Bleaching agents come in a variety of concentrations and there are over-the-counter products available on the market with lower concentrations of hydrogen peroxide. Due to the chemical characteristics of the agents, changes in the organic and inorganic content of the tooth structure can be observed. These changes are related to morphological changes characterized by in-creased permeability and surface roughness, such changes compromise the mechanical resistance of the tooth. Furthermore, bleaching agents can promote molecular changes after reaching the dental pulp, resulting in oxidative stress of pulp cells and the release of pro-inflammatory mediators. Despite the bleaching effectiveness, tooth sensitivity is considered the main side effect of use. Therefore, among the heterogeneity of protocols, those that used the bleaching agent for a prolonged time and in lower con-centrations presented more harmful effects on the tooth structure.

2024-09-01·Operative Dentistry

Effect of Successive At-home Bleaching Sessions on the Surface Properties, Biaxial Flexural Strength, and Reliability of CAD-CAM Monolithic Materials

Article

作者: Amaro, LF ; Dovigo, LN ; Adabo, GL ; Fonseca, RG ; Massucatto, LO ; Queiroz, JFC

SUMMARYAlthough at-home bleaching can recover the optical properties of stained CAD-CAM monolithic materials, little is known about its impact on their surface and mechanical properties, especially when successive sessions are performed. This study evaluated the effect of successive at-home bleaching sessions on the microhardness, roughness, topography, biaxial flexural strength (BFS), and reliability of CAD-CAM monolithic materials. Disks from Lava Ultimate (LU), Vita Enamic (VE), and IPS Empress CAD (EMP) were fabricated and submitted to up to three bleaching sessions. At-home bleaching was performed with 10% carbamide peroxide, and each session consisted of one application for 10 hours/day for 14 days. The analyses of the aforementioned parameters were assessed before and after the first, second, and third bleaching sessions, except for BFS, which was evaluated at baseline and after the third session. The Weibull modulus was calculated from the BFS data. The microhardness of the three materials as well as the roughness of LU were not affected by the sessions, whereas the roughness of VE and EMP increased from the second session. All materials displayed topographic changes, which became more pronounced with the increase in the number of sessions. Although bleaching decreased the BFS of the materials, it did not adversely affect their reliability. Successive at-home bleaching sessions with the protocol used in the present study cannot be considered a safe procedure for the materials evaluated.

2024-08-01·Clinical and Experimental Dental Research

Effects of Different Concentrations of Carbamide Peroxide on Color, Surface Roughness, and Hardness of CAD/CAM Dental Ceramics

Article

作者: Jamshidi, Saman ; Alaghemand, Homayoun ; Gholinia, Hemmat ; Esmaeili, Behnaz

ABSTRACTObjectivesThis study assessed the effects of 15% and 20% carbamide peroxide (CP) on color, surface roughness, and hardness of computer‐aided design/computer‐aided manufacturing (CAD/CAM) dental ceramics.Materials and MethodsThis in vitro study was conducted on 120 Vita Mark II, Celtra Duo, and Suprinity CAD/CAM ceramic specimens. The ceramic specimens in each group (n = 40) were randomly assigned to two subgroups (n = 20) for polishing and glazing, and their baseline color, surface roughness (Ra), and hardness were assessed. In each subgroup, half of the specimens were exposed to 15% CP, while the other half were exposed to 20% CP. Their color change (ΔE), surface roughness, and hardness were then measured again. Surface roughness, hardness, and color were analyzed sequentially by profilometer, Vickers hardness tester, and spectrophotometer, respectively. Data were analyzed by repeated measures ANOVA, one‐way ANOVA, and post hoc Bonferroni test (α = 0.05).ResultsThe surface roughness of all groups significantly increased after bleaching treatment (p < 0.05). Surface hardness of all groups decreased after bleaching treatment, but this reduction was only significant in Vita Mark II subgroups (glazed, polished, 15%, and 20% CP). The ΔE was not clinically and visually perceivable in any group.ConclusionThe present results revealed that concentration of CP and type of surface treatment affected the surface properties of CAD/CAM ceramics. Type of surface treatment only affected the surface hardness of Vita Mark II ceramics (p < 0.05). Concentration of CP had a significant effect only on polished Vita Mark II.

100 项与过氧化碳酰胺相关的药物交易

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