5-Fluoroindole(5-Fluoroindole) - 在研适应症：结核_专利_临床

概要

基本信息

药物类型

小分子化药

别名

5-FI.HCl

靶点-

作用机制-

治疗领域

感染

在研适应症

结核

非在研适应症-

原研机构-

在研机构

Pontifical Catholic University of Rio Grande Do Sul

非在研机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 5-Fluoroindole 相关的临床结果

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100 项与 5-Fluoroindole 相关的转化医学

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100 项与 5-Fluoroindole 相关的专利（医药）

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1

项与 5-Fluoroindole 相关的文献（医药）

Chemistry & Biodiversity

In vitro Evaluation of Endocrine‐Related Adverse Effects of 5‐Fluoroindole Derived Melatonin Analogues with Antioxidant Activity

Article

作者: Suzen, Sibel ; Tekiner, Betul ; Fatullayev, Hanifa ; Ince Erguc, Elif ; Gurer-Orhan, Hande ; Entezari, Bita

Melatonin (MLT) is a natural indolic hormone and its antioxidant activity has been reported through various mechanisms. MLT interacts with the estrogen signaling pathway by inhibiting aromatase enzyme, and it has been suggested that these new compounds may have endocrine‐related adverse effects due to their selective estrogen modulator activity. In this study, we investigated the aromatase inhibitory and estrogen receptor agonist/antagonist effects as well as possible antioxidant activity of MLT analogue 5‐floro indole derivatives for being potential drug candidates in the prevention and treatment of oxidative stress related diseases. Among the 34 compounds tested, three compounds showed antioxidant effect through radical scavenging activity and reducing the formation of intracellular reactive oxygen species. They also showed varying potencies of antiestrogenic and/or aromatase inhibitory activity which should be considered as a potential untargeted effect of MLT and its analogues.

100 项与 5-Fluoroindole 相关的药物交易

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