Awake Nasal Intubation With a Flexible Nasolaryngoscope in Patients With Laryngeal, Oro and Hypo-pharynx Tumours With Midazolam-fentanyl-droperidol Sedation Protocol- Technique and Patient Satisfaction

This study evaluates the efficiency of awake naso-tracheal intubation and patient satisfaction when using a small diameter flexible nasolaryngoscope together with topical anaesthesia and light sedation with a combination of benzodiazepine and fentanyl. The selected patients will have difficult airway access because of obstructing oro- and hypo-pharynx tumours.

开始日期2018-02-20

申办/合作机构

Iuliu Hatieganu University of Medicine & Pharmacy

100 项与 SL-017 相关的临床结果

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100 项与 SL-017 相关的转化医学

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100 项与 SL-017 相关的专利（医药）

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项与 SL-017 相关的文献（医药）

2024-09-01·Journal of Cutaneous Medicine and Surgery

Treatment of Post-Inflammatory Hyperpigmentation in Skin of Colour: A Systematic Review

Review

作者: Mar, Kristie ; Maazi, Mahan ; Ahmed, Rayan ; Wang, Ou Jia (Emilie) ; Khalid, Bushra ; Khosravi-Hafshejani, Touraj

Post inflammatory hyperpigmentation (PIH) affects all skin types with a heightened predilection for darker skin tones. Its course is chronic once developed and treatment is often difficult. This systematic review aims to summarize the treatment outcomes for PIH with a focus on skin of colour (SOC) individuals. A literature search was conducted using MEDLINE (from 1946), Embase (from 1974), PubMed, and Cochrane in adherence to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guideline. Results from 48 studies summarized 1356 SOC individuals. The mean age was 29 years (n = 1036) and 78% were female (n = 786). The ethnic prevalence was 70% Black, 27% Asian, and 3% Latin. Overall, 20% were Fitzpatrick skin type (FST) III, 40% FST IV, 34% FST V, and 6% FST VI. Most cases were precipitated by inflammatory conditions (89%) and localized to the face (83%). The most frequently reported interventions were topical retinoids (22%) and laser therapy (17%). Partial improvement was seen in 85% and 66% of participants, respectively. Laser was the only intervention that offered complete resolution in a subgroup of patients (26%); however, there were reported cases of PIH exacerbation following treatment. Chemical peels (9%) and hydroquinone (7%) were among other treatments with less effective outcomes. PIH and its persistence is a prevalent issue, significantly affecting many affected individuals with darker skin tones. Our results show a lack of robust efficacy across all treatment modalities. There is considerable room for improvement in interventions for at-risk populations.

2024-09-01·JAAD International

Racial differences in tolerability of topical retinoids: A 15-year single-center retrospective cohort study

Article

作者: Kim, Dae Hyun ; Chung, Hye Jin ; Hsu, Sarah Hahn ; Chang, Yu-Feng ; Chen, Li-Chi

2024-05-01·Journal of the American Academy of Dermatology

Guidelines of care for the management of acne vulgaris

Review

作者: Druby, Kelly M ; Barbieri, John S ; Reynolds, Rachel V ; Tollefson, Megha M ; Tan, Jerry K L ; Cheng, Carol E ; Cook-Bolden, Fran ; Yeung, Howa ; Keri, Jonette E ; Weiss, Jonathan S ; Han, Jung Min ; Freeman, Esther E ; Zaenglein, Andrea L ; Wu, Peggy A ; Stein Gold, Linda F ; Desai, Seemal R

BACKGROUNDAcne vulgaris commonly affects adults, adolescents, and preadolescents aged 9 years or older.OBJECTIVEThe objective of this study was to provide evidence-based recommendations for the management of acne.METHODSA work group conducted a systematic review and applied the Grading of Recommendations, Assessment, Development, and Evaluation approach for assessing the certainty of evidence and formulating and grading recommendations.RESULTSThis guideline presents 18 evidence-based recommendations and 5 good practice statements. Strong recommendations are made for benzoyl peroxide, topical retinoids, topical antibiotics, and oral doxycycline. Oral isotretinoin is strongly recommended for acne that is severe, causing psychosocial burden or scarring, or failing standard oral or topical therapy. Conditional recommendations are made for topical clascoterone, salicylic acid, and azelaic acid, as well as for oral minocycline, sarecycline, combined oral contraceptive pills, and spironolactone. Combining topical therapies with multiple mechanisms of action, limiting systemic antibiotic use, combining systemic antibiotics with topical therapies, and adding intralesional corticosteroid injections for larger acne lesions are recommended as good practice statements.LIMITATIONSAnalysis is based on the best available evidence at the time of the systematic review.CONCLUSIONSThese guidelines provide evidence-based recommendations for the management of acne vulgaris.

项与 SL-017 相关的新闻（医药）

2023-03-13

·生物谷

有望实现零的突破！PNAS：新研究揭示细胞组织供氧原理，改善组织氧合药物的研发迎来曙光！

外周动脉疾病、镰状型细胞贫血症、心力衰竭、中风、肺气肿等心血管相关疾病是当今社会的隐形杀手。每年有数百万人死于这些疾病。而微血管中的血流和氧气运输受阻是引发这些疾病的两大重要因素。虽然有诸多药物可以舒张血管改善血液流动，但是目前却没有获批的药物可以改善缺氧组织内的氧合状态。最近发表在 PNAS 的一项突破性研究让改善组织氧合药物的研发迎来曙光【1】。在这项里程碑式的研究中，来自大学医院 (UH) 哈灵顿发现研究所（Harrington Discovery Institute）和凯斯西储大学（Case Western Reserve University）医学院的研究人员在小鼠和人体中发现，S-亚硝基血红蛋白（S-nitrosolhemoglobin, SNO-Hb）可以感知缺氧区域，进而调节血流以供氧，是一种控制血流和组织氧合的生物标志物。因此，提高SNO-Hb水平有望改善微循环障碍患者的组织氧合状态。SNO-Hb 是整合血流自主调控和组织氧合的中枢那么，什么是SNO-Hb，它是如何感知组织氧合状态调控氧气运输的呢？一直以来，血氧蛋白（Hb）被认为是调控氧气运输的主要因素。而事实上，在大多数生理条件下，组织中的血流量，而非血液含氧量，才是氧气运输调控的关键所在。血流量又是如何与组织氧合状态联系起来的呢？奥秘就蕴藏在血氧蛋白β 链第93 位保守的半胱氨酸（Cys）残基 (βCys93) 中。这种半胱氨酸结合一氧化氮 (NO)形成S-亚硝基硫醇 (SNO)。氧化状态下，SNO结合血氧蛋白生成 S-亚硝基血红蛋白 (SNO-Hb)；在血氧蛋白脱氧后，一氧化氮被释放。由于 SNO还具有舒张血管的作用，SNO-Hb进而将血流自主调控和组织氧合联系在一起。图注：一氧化氮（NO）与血红蛋白（Hb）的相互作用【2】SNO-Hb缺失的小鼠微血管功能受阻为研究SNO-Hb的临床重要性，研究人员在小鼠中表达人的血氧蛋白，并用丙氨酸（Ala）替换βCys93构建SNO-Hb缺失的基因突变型小鼠Cys93Ala (C93A) 。之后他们分别对C93A小鼠和C93小鼠（对照组，表达正常的人血红蛋白）进行下肢反应性充血实验来探究SNO-Hb对小鼠微血管功能的影响。类似于临床充血测试，该实验使用大腿袖带闭塞股动脉 5 分钟后松开，同时用插入腓肠肌的针头探头测量肌肉的氧分压（pO2）。实验结果显示SNO-Hb 的缺失不仅会导致正常状态下的组织缺氧，还会减缓血流短暂中断后组织的复氧速度。图注：小鼠的反应性充血实验显示肌肉氧合在 HbβCys93 突变小鼠（C93A）中受损【1】SNO-Hb水平与组织氧合状态成正相关SNO-Hb在人体中是否有同样的功能呢？为探究人体中SNO-Hb在反应性充血测试中的主要作用，研究人员招募了53位受试者，包括健康对照者、全身或外周氧合缺陷的相关疾病患者、糖尿病外周动脉疾病（PAD）患者、心力衰竭（HF）患者、慢性阻塞性肺病（COPD）患者以及镰刀型细胞贫血症（SCD）患者。其中，由于可能存在局部缺血诱发血管闭塞的风险，镰刀型细胞贫血症患者未接受反应性充血试验）。研究人员收集了受试者的桡动脉血样以测量红细胞的 SNO-Hb 水平。采血后，他们使用近红外光谱(NIRS) 设备测量了远端肢体（足）的组织氧合。最后，他们对组织氧合恢复的半衰期（Recovery t1/2，阻塞血管后组织恢复基线氧合水平的一半所需的时间）进行记录以便研究半衰期与SNO-Hb水平之间的关系。实验结果表明SNO-Hb水平与组织氧合恢复的半衰期Recovery t1/2成负相关，患者血液中的SNO-Hb水平显著低于健康对照。这意味着提升SNO-Hb水平可能有助于改善组织氧合状态。图注：SNO-Hb水平与组织氧合恢复的半衰期Recovery t1/2成负相关（与半衰期的倒数1/Recovery t1/2成正相关）【1】图注：患者血液中的SNO-Hb水平显著低于健康对照【1】改善组织氧合药物的曙光文章通讯作者Stamler博士表示：“这项研究表明，组织获取氧气需要通过血红蛋白进行血管舒张。因为血红蛋白准确地知道身体中氧气含量低的位置，然后它会自行调整以按需释放血管舒张剂一氧化氮。”【3】Stamler 及其同事目前正致力于开发用一氧化氮修饰血红蛋白以形成 S-亚硝基血红蛋白的药物。这些新药首次在血氧含量很低的情况下改善组织氧合状态。这无疑让相关药物的研发迎来了曙光，为心肺血液疾病患者带来了福音！参考文献：1、Reynolds, J.D., et al. (2023) Control of tissue oxygenation by S-nitrosohemoglobin in human subjects. PNAS. doi.org/10.1073/pnas.2220769120.2、Zhang, Y., Hogg, N., 2004. S-nitrosohemoglobin: a biochemical perspective. Free Radical Biology and Medicine 36, 947–958. https://doi.org/10.1016/j.freeradbiomed.2004.01.0083、Henderson, R. by E. (2023, March 1). Landmark Discovery provides a new perspective on tissue oxygenation. News. Retrieved March 9, 2023, from https://www.news-medical.net/news/20230301/Landmark-discovery-provides-a-new-perspective-on-tissue-oxygenation.aspx 撰稿 | Qianyue编辑 | cici会议推荐RECOMMENDATIONS点击了解详情点击了解详情精彩推荐：1、破解20年难题！《Nature》重磅：揭示调控细胞内基因转录的“红绿灯”机制！2、周末补觉也无用？超过十万样本量结果显示：良好的睡眠可降低死亡风险，或让男性预期寿命延长4.7年，女性延长2.4年！3、大脑如何知道感染了甲流？Nature：哈佛医学院团队发现流感信息由气道直达大脑的信号通路4、“无肉不欢”是真的！近1.5万人研究表明：不吃肉，抑郁发作风险增加165%！5、女性提早补充更有益！10年随访研究近1.3万人发现：经常补充维生素D痴呆风险下降40%，还能降低死亡风险！

100 项与 SL-017 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	-	DB05156

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
寻常痤疮	临床3期	-	KM (Holdings) Ltd.	-
寻常痤疮	临床3期	-	Quest PharmaTech, Inc.	-
寻常痤疮	临床3期	-	Quest PharmaTech, Inc.	-
寻常痤疮	临床3期	-	KM (Holdings) Ltd.	-
光化性角化病	临床3期	-	KM (Holdings) Ltd.	-
光化性角化病	临床3期	-	Quest PharmaTech, Inc.	-
光化性角化病	临床3期	-	KM (Holdings) Ltd.	-
光化性角化病	临床3期	-	Quest PharmaTech, Inc.	-