The purpose of this study was to investigate the anti-inflammatory effect of tegoprazan (TEGO) in lipopolysaccharide (LPS)-stimulated bone-marrow-derived macrophages (BMMs). To this end, compared to methylprednisolone (MP; positive control), we evaluated whether TEGO effectively differentiates LPS-stimulated BMMs into M2-phenotype macrophages. Moreover, the expression of pro- and anti-inflammatory cytokines genes influenced by TEGO was measured using quantitative real-time polymerase chain reaction (qRT-PCR) analysis. TEGO was found to reduce nitric oxide (NO) production in BMMs significantly. In addition, TEGO significantly decreased and increased the gene expression levels of pro-inflammatory and anti-inflammatory cytokines, respectively. In addition, we evaluated the phosphorylated values of the extracellular signal-regulatory kinase (ERK) and p38 in the mitogen-activated protein (MAP) kinase signaling pathway through Western blotting. TEGO significantly reduced the phosphorylated values of the ERK and p38. In other words, TEGO suppressed the various pro-inflammatory responses in LPS-induced BMMs. These results show that TEGO has the potential to be used as an anti-inflammatory agent.

2022-03-01·The Journal of craniofacial surgery4区 · 医学

Chemical Sterilization of Lipoplasty Cannula and Nontuberculous Mycobacteria Disinfection: An Experimental Study

4区 · 医学

Article

作者: Kim, Deok-Woo ; Lee, Tae-Yul ; Kim, Min-Sook ; Lee, Yun-Hwan ; Kim, Hyung-Kyu ; You, Hi-Jin

Background::

Nontuberculous mycobacteria are commonly found pathogens; however, skin and soft tissue infections due to nontuberculous mycobacteria are often associated with surgical procedures, particularly after lipoplasty. Although nontuberculous mycobacteria are resistant to some chemical disinfectants, glutaraldehyde, peracetic acid, povidone iodine, alcohol, and chlorine are still used for the sterilization of medical instruments. This study investigated the efficacy of various disinfectants in a fatty environment with adipose and a bloody environment without adipose. In addition, this study was also used to identify the most effective disinfectant against nontuberculous mycobacteria.

Methods::

Three nontuberculous mycobacteria (Mycobacterium avium, M. abscessus, and M. fortuitum), pathogens frequently found in skin and soft tissue infections, were used. Seven chemical disinfectants were tested in both fatty and bloody environments. The disinfectants used were considered to have a sterilization effect when the log10 reduction factor exceeded 5.

Results::

Most disinfectants had some sterilizing effects against nontuberculous mycobacteria; however, glutaraldehyde was the most effective against all 3. Chlorhexidine and povidone iodine also displayed sterilizing effects. Of the disinfectants tested, only alkyldiaminoethylglycine hydrochloride showed a diminished effect with statistical significance, specifically against M. fortuitum in a fatty environment, whereas it had effective results in a bloody environment.

Conclusions::

Glutaraldehyde showed the greatest sterilizing effect on nontuberculous mycobacteria with a log10 reduction factor >5 in both fatty and bloody environments. However, some chemical disinfectants did not show sufficient sterilizing effects in a fatty environment and, therefore, should be used with caution for the sterilization of nontuberculous mycobacteria.

Level of Evidence::

Level II

2021-03-16·Pharmaceutical development and technology4区 · 医学

Preparation and characterization of dexamethasone lipid nanoparticles by membrane emulsification technique, use of self-emulsifying lipids as a carrier and stabilizer

4区 · 医学

Article

作者: Staufenbiel, Sven ; Ali, Rebaz

Self-emulsifying lipids (SEL) were used as a stabilizer for the preparation of dexamethasone lipid nanoparticles by membrane emulsification employing Shirasu porous glass. The effect of process and formulation parameters on the size and polydispersity and dexamethasone solubility in lipids and its release from lipid nanoparticles were investigated. Lipid phase pressure (40-80 kPa), membrane pore-size (0.1 - 0.4 µm) and agitation speed (300 - 900 rpm) did not affect the size and polydispersity of SEL. However, the size was increased with increasing lipid content and fatty acid chain of the lipid. Sizes of < 250 nm were achieved from TEGO^® care:Gelucire^® blend and it increased to 487 nm by adding 20% w/w of hard fat. The highest solubility of dexamethasone was found in TEGO^® care 450 (29 mg/g). Release from the lipid nano-dispersions was extended with no burst effect and the absolute release was increased with increasing lipid content.

项与烷基二氨基乙基甘氨酸盐酸盐相关的新闻（医药）

2023-11-15

·Coatings World

Evonik and Circular Economy: At Least €1B in Added Sales by 2030

Evonik is significantly expanding its commitment to developing solutions for the circular economy. From 2030, the specialty chemicals company aims to generate at least €1 billion in additional sales a year from circular products and technologies. "The circular economy is a strong growth driver for Evonik and helps us to generate sustainable value," said Harald Schwager, deputy chairman of the Executive Board of Evonik. The Group's circular economy strategy is based on several levers: Evonik wants to further strengthen its activities with additives and specialties for the circular economy. At the same time, Evonik intends to make greater use of defossilized raw materials based on recycled materials, biomass and CO2. The company also continues to develop its own technologies for closing the loop: for example, for chemical recycling of PET waste streams that cannot be recycled mechanically. It is also developing technologies that allow carbon dioxide and bio-based raw materials as feedstock. “We want to make the entire industry circular,” Lauren Kjeldsen, head of the Smart Materials Division and responsible for the Circular Economy Program, said. “With our expertise in specialty chemicals, we support our customers in the transition to circular applications by making their manufacturing processes more efficient and improving quality in line with Design for Circularity." Many of Evonik's products already contribute to the circular economy in various value chains. Examples include: • Products based on circular raw materials that are labeled eCO in the product name, such as VESTAMID eCO • Additives to improve the efficiency and yield of recycling processes and the quality of recycled materials, for example in mechanical plastics recycling with TEGO® Cycle • CHLOROCEL adsorbents for removing impurities in chemical plastics recycling • DEGACRYL heat seal binder for the production of mono-material packaging that is particularly easy to recycle • Improved durability and service life thanks to high-performance plastics (VESTAMID) and crosslinkers (VESTAMIN, VESTANAT)

2023-10-27

·Coatings World

New Evonik TEGO Guard 9000 Protects Facades from Moment of Application

While the formulation of exterior paints may differ around the world, the challenge of protecting buildings from environmental impact seems universal. With the new additive TEGO® Guard 9000 from Evonik Coating Additives, it is possible to protect building facades from the moment of application. “The application of facade paints has been highly dependent on the weather, as newly applied facade coatings had traditionally long drying times, making them more vulnerable to water and dirt,” said Ellen Reuter, head of the Decorative market segment for the EMEA region. “Evonik’s new TEGO Guard 9000 addresses this key customer pain-point by improving the stabilization of paint ingredients in facade coatings and providing almost immediate protection against weathering.” While conventional high pigment volume concentration (PVC) exterior facade coatings typically take three hours or more to dry, the new ‘Quick-Set property’ of TEGO Guard 9000 technology enables high rain resistance just a few minutes after application. The technology promotes electrostatic interaction between a cationic organic polymer and the anionic paint ingredients in the coating formulation. Additionally, the special formulation of TEGO Guard 9000 allows for customized addition to formulations without affecting storage stability. The additive can be used universally, regardless of the binder, PVC and color selected, and is suitable for environmentally friendly waterborne facade coatings. “Coating formulators using TEGO Guard 9000 can offer innovative and environmentally friendly facade coatings that can be applied more flexibly and regardless of weather conditions,” said Katina Kiep, head of the Global Decorative market segment at Evonik Coating Additives. “Due to the increasing unpredictability of extreme weather caused by climate change, and more stringent regulatory requirements, there is a growing demand for facade coatings that offer immediate weather resistance and long-lasting protection against environmental impacts.”

2023-06-06

·Coatings World

Evonik Introduces TEGO Rad 2550 Slip and Defoamer Additive

Evonik's Coating Additives business line is expanding its TEGO Rad range of tailored silicone acrylates with a new radically crosslinkable defoaming slip additive. The new TEGO Rad 2550 is a clear, low viscosity liquid that effectively reduces static and dynamic surface tension in both conventional UV- and LED-cured formulations. Key attributes include low coefficient of friction (COF), high scratch resistance, good defoaming and the ability to create hydrophobic surfaces. “Due to its unique property profile, TEGO® Rad 2550 is truly an excellent additive for the formulation of matte coatings, pigmented inks, and roller-applied wood top-coats,” said Courtney Thurau, head of Evonik’s Global Market Segment for Printing Inks. Acrylated products are the coating industry’s first choice for minimizing migration and obtaining very pronounced, long-lasting effects. TEGO Rad 2550 is just one of the latest products in Evonik’s TEGO Rad portfolio of silicone acrylates that offer formulators a complete toolbox of solutions to ensure top performance in paints and coatings. These additives for radiation-curing inks and coatings can improve the flow and leveling and optical appearance, prevent cratering, and allow formulators to create products with the desired level of slip and flow. Choosing TEGO® Rad products with a higher or lower number will result in a different level of slip and compatibility, giving customers more precision in their formulations. “TEGO® Rad products offer tailored, cross-linkable performance. For inks and coatings formulators, this means great long-term effectiveness in the final product, high resource-efficiency and a sustainable solution compared to alternative technologies,” said Thurau.

100 项与烷基二氨基乙基甘氨酸盐酸盐相关的药物交易

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