刺桐提取物(Erythrina mulungu Extract)

概要

基本信息

药物类型

中药

别名

Mulungu、Mulungu Matusa, Erytrina mulungu

靶点-

作用机制-

治疗领域

其他疾病

在研适应症-

非在研适应症

焦虑症

原研机构-

在研机构-

非在研机构

University of Campinas

Fundação Universidade Federal de Sergipe

最高研发阶段无进展临床2/3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

2

项与刺桐提取物相关的临床试验

NCT02065843 / Completed临床2/3期IIT

Comparative Study of the Effectiveness of Three Anxiolytic Drugs Used in Third Molar Surgery

This study was to compare the effectiveness of three drugs (Passiflora incarnata, Erythrina mulungum, Midazolam) in controlling anxiety in patients undergoing bilateral extraction of asymptomatic, impacted mandibular third molars.

开始日期2014-03-01

申办/合作机构

Fundação Universidade Federal de Sergipe

[+1]

NCT01948622 / Completed临床1/2期IIT

Anxiety Control by Using Erythrina Mulungu in Mandibular Third Molars Extraction

This study evaluated the effectiveness of the Erythrina mulungu in controlling anxiety in patients undergoing bilateral extraction of asymptomatic, impacted mandibular third molars.

开始日期2012-01-01

申办/合作机构

Fundação Universidade Federal de Sergipe

[+1]

100 项与刺桐提取物相关的临床结果

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100 项与刺桐提取物相关的转化医学

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100 项与刺桐提取物相关的专利（医药）

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4

项与刺桐提取物相关的文献（医药）

2021-03-01·Clinical Oral Investigations2区 · 医学

Herbal medicines as anxiolytics prior to third molar surgical extraction. A randomized controlled clinical trial

2区 · 医学

Article

作者: Groppo, Francisco Carlos ; da Cunha, Rafael Soares ; Amorim, Klinger Souza ; Gercina, Anne Caroline ; de Oliveira, Allan Carlos Araújo ; Souza, Liane Maciel Almeida ; Dos Santos Menezes, Liciane

OBJECTIVESThis study aimed to compare the effects of Passiflora incarnata, Erythrina mulungu, and midazolam in controlling anxiety in patients undergoing mandibular third molar extraction.METHODSThe volunteers underwent extraction of their third mandibular molars in a randomized, placebo-controlled, triple-blind, and parallel clinical trial. Passiflora incarnata (500 mg), Erythrina mulungu (500 mg), or midazolam (15 mg) was orally administered 60 min before the surgery. The anxiety level of participants was evaluated using questionnaires and measurements of physical parameters, including heart rate (HR), blood pressure (BP), and oxygen saturation (SpO₂).RESULTSA total of 200 volunteers were included in this clinical trial. Considering each procedure independently, no significant differences (p > 0.05) in BP, HR, and SpO₂ were observed among the protocols.CONCLUSIONSPassiflora incarnata showed a similar effect to midazolam but differed from placebo and mulungu, which were unable to control anxiety in this situation. Therefore, the results suggest that Passiflora configures an herbal medicine with an anxiolytic effect, adequate to use in third molar extractions.CLINICAL RELEVANCEThe use of Passiflora incarnata may be an alternative to benzodiazepines for controlling anxiety in patients scheduled for oral surgery under local anesthesia.TRIAL REGISTRATIONClinicalTrials.gov : ANSI-388.427.

2021-01-01·BMJ Open4区 · 医学

Effectiveness and safety of oral sedation in adult patients undergoing dental procedures: a systematic review

4区 · 医学

ReviewOA

作者: Araújo, Jimmy de Oliveira ; Bergamaschi, Cristiane de Cássia ; de Andrade, Natalia Karol ; Guimarães, Caio Chaves ; Motta, Rogério Heládio Lopes ; Lopes, Luciane Cruz ; Ramacciato, Juliana Cama

ObjectivesIt can be challenging to manage patients who are anxious during dental procedures. There is a lack of evidence regarding the effectiveness and safety of oral sedation in adults. This study evaluated the effectiveness and safety of oral sedation in patients undergoing dental procedures.DesignSystematic review.MethodsRandomised clinical trials (RCTs) compared the oral use of benzodiazepines and other medications with a placebo or other oral agents in adult patients. A search of the Cochrane (CENTRAL), MEDLINE (via Ovid), EMBASE (via Ovid) and Cumulative Index to Nursing and Allied Health Literature (via Ovid) databases was conducted, without any restrictions on language or date of publication. The primary outcomes included the adverse effects and anxiety level. The secondary outcomes included sedation, satisfaction with the treatment, heart rate, respiratory rate, blood pressure and oxygen saturation. Reviewers, independently and in pairs, assessed each citation for eligibility, performed the data extraction and assessed the risk of bias. A narrative synthesis of the data was provided.ResultsA number of RCTs (n=327 patients) assessed the use of benzodiazepines (n=9) and herbal medicines (n=3). We found good satisfaction with treatment after the use of midazolam 7.5 mg or clonidine 150 µg and reduced anxiety with alprazolam (0.5 and 0.75 mg). Midazolam 15 mg promoted greater anxiety reduction than Passiflora incarnata L. 260 mg, while Valeriana officinalis 100 mg and Erythrina mulungu 500 mg were more effective than a placebo. More patients reported adverse effects with midazolam 15 mg. Diazepam 15 mg and V. officinalis 100 mg promoted less change in the heart rate and blood pressure than a placebo.ConclusionsGiven the limitations of the findings due to the quality of the included studies and the different comparisons made between interventions, further RCTs are required to confirm the effectiveness and safety of oral sedation in dentistry.PROSPERO registration numberCRD42017057142.

2007-03-01·Journal of Ethnopharmacology2区 · 医学

Anticonvulsant activity of hydroalcoholic extracts from Erythrina velutina and Erythrina mulungu

2区 · 医学

Article

作者: Geanne M.A. Cunha ; Marta Maria F. Fonteles ; Edilderto R. Silveira ; Glauce Socorro B. Viana ; Francisca Cléa F. Sousa ; Natália M. Lima ; Gabriel T.M. Sales ; Alexandre C.P. Rodrigues ; Silvânia M.M. Vasconcelos ; Lissiana M.V. Aguiar ; Daniele S. Macedo

The anticonvulsant effects of hydroalcoholic extracts (HAEs) from the stem bark of Erythrina velutina and Erythrina mulungu on pentylenetetrazole (PTZ) and strychnine-induced seizure tests and the potentiation of pentobarbital-induced sleeping time in mice with the extracts were examined in this study. These medicinal plants belong to the Fabaceae family and are popularly used in Brazil for their effects on the central nervous system. The extracts of Erythrina velutina (intraperitoneally or orally) and Erythrina mulungu (intraperitoneally) were administered in mice at single doses (200 or 400mg/kg). While Erythrina velutina and Erythrina mulungu did not exhibit any protector effect in PTZ-induced seizures, at any dose, an increase in the latency of convulsion and in the death time was observed with both doses and routes of Erythrina velutina and at higher dose of Erythrina mulungu, in strychnine-induced seizure. No alteration was observed with Erythrina velutina and Erythrina mulungu on sleeping latency at both doses as compared to control (362.8+/-59.5). However, the sleeping time was increased in both plants as compared to control (943.8+/-129.6). In conclusion, we showed that the hydroalcoholic extracts of Erythrina velutina and Erythrina mulungu have anticonvulsant effects only in the strychnine-induced seizure model, suggesting their possible action in glycine system and a potentiation of pentobarbital sleeping time, suggesting depressant action in the central nervous system.

100 项与刺桐提取物相关的药物交易

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