更新于：2024-11-04
Articaine Hydrochloride/Epinephrine Bitartrate
盐酸阿替卡因/重酒石酸肾上腺素
更新于：2024-11-04
概要
基本信息
药物类型 小分子化药 |
别名 Articaine Hydrochloride and Epinephrine Tartrate、Compound Articaine Hydrochloride、复方盐酸阿替卡因 + [8] |
作用机制 ADRA1激动剂(肾上腺素能受体α-1家族激动剂)、SCNA调节剂(钠通道α亚基家族调节剂)、β-adrenoceptors激动剂(β-肾上腺素能受体家族激动剂) |
治疗领域 |
在研适应症 |
非在研适应症 |
原研机构 |
非在研机构 |
最高研发阶段批准上市 |
首次获批日期 德国 (1976-01-01), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C13H21ClN2O3S |
InChIKeyGDWDBGSWGNEMGJ-UHFFFAOYSA-N |
CAS号23964-57-0 |
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关联
9
项与 盐酸阿替卡因/重酒石酸肾上腺素 相关的临床试验Study of Tramadol Addiction Impact on Dental Anesthesia Succes.
Efficacy and Safety of Articaine and Lidocaine in Extraction of Wisdom Teeth of Upper and Lower Jaws
Comparison of the Efficacy and Safety of Two Homologous Active Principles for Local Dental Anesthesia: Non-inferiority Trial
100 项与 盐酸阿替卡因/重酒石酸肾上腺素 相关的临床结果
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100 项与 盐酸阿替卡因/重酒石酸肾上腺素 相关的转化医学
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100 项与 盐酸阿替卡因/重酒石酸肾上腺素 相关的专利（医药）
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32
项与 盐酸阿替卡因/重酒石酸肾上腺素 相关的文献（医药）2023-05-18Animals : an open access journal from MDPI
Effects of Different Co-Feeding Protocols on the Early Weaning of Flathead Grey Mullet (Mugil cephalus) Larvae.
Article
作者: Loi, Barbara ; Quirós-Pozo, Raquel ; Concu, Danilo ; Vallainc, Dario ; Roo, Javier ; Robaina, Lidia
The sustainable expansion of aquaculture relies on a sufficient supply of eggs and larvae, which are the first step of life cycle management. However, marine fish larval rearing generally depends on live feed production, which needs additional facilities and labor. The flathead grey mullet (Mugil cephalus), a promising species for aquaculture diversification, has a precocious digestive system development, supporting the feasibility of early weaning strategies. For these reasons, this study evaluated survival, growth, proximate and fatty acid composition, and gene expression of Mugil cephalus larvae reared under three different weaning protocols. Three co-feeding treatments, two with different Artemia sp. concentrations (A100 and A50, 2 and 1 Artemia sp. mL-1 day-1, respectively) and one with only rotifers administered as live feed along the feeding trial (A0), were assessed from 22 to 36 days post-hatching (dph). The A0 treatment performed better in survival (64.79 ± 7.40%) than the A100 protocol (32.46 ± 12.82%). In contrast, the larvae of the A100 treatment presented significantly higher final length (15.51 ± 0.86 mm) than those of the A0 treatment (12.19 ± 1.45 mm) and higher final weight (41.28 ± 1.48 mg) than those of the A50 and A0 treatments (31.23 ± 3.65 mg and 24.03 ± 7.99 mg, respectively). On the other hand, the expression of digestive enzyme- and somatotropic factor-related genes did not show differences between treatments. The present results support the convenience of treatment A0 in maximizing survival, as rotifers should be maintained until 30-32 dph (until a total larval length of at least 10 mm). However, to improve growth and minimize size dispersion, Artemia sp. addition is recommended from day 26 to day 29 post-hatching (total larval length of 8 to 9 mm).
2021-10-01Journal of hazardous materials1区 · 环境科学与生态学
The synergistic effect of enhanced photocatalytic activity and photothermal effect of oxygen-deficient Ni/reduced graphene oxide nanocomposite for rapid disinfection under near-infrared irradiation
1区 · 环境科学与生态学
Article
作者: Sun, Jingyu ; Wu, Guizhu ; Chen, Xue ; Liu, Lu ; Guo, Donggang ; Jin, Zhengguo ; Zhang, Ze
The rational design of high antibacterial efficiency are urgently needed as the occurrence of drug-resistance issues. Hence, Ni/reduced graphene oxide nanocomposite (Ni/rGO) with different amounts of oxygen vacancies were fabricated for efficient disinfection. The optimized Ni/rGO (A100) exhibited highly effective inactivation efficacy of 99.6% and 99.5% against Escherichia coli and Bacillus subtilis within 8 min near-infrared (NIR) irradiation through the synergistic effects of photothermal therapy and oxidative damage, which were much higher than single treatment. The A100 nanocomposite achieved an extraordinary photothermal conversion efficiency (35.78%) under the 808 nm irradiation for enhanced photothermal hyperthermia, thereby destroying the cell membrane and accelerating the GSH depletion. The radical scavenger experiment confirmed that •O2- and •OH play the chief role in photodisinfection reaction. Besides, A100 could exert significant damage on the ATP synthesis. The excellent photothermal performance and photocatalytic activity can be attributed to the appropriate oxygen vacancy density, which improves the absorption of NIR light and facilitates the separation of photogenerated electron-hole pairs. Besides, the higher NiO content of A100 contributed to improving the photocatalytic effect. Our work demonstrated a promising strategy for efficient water pollution purification caused by pathogenic bacteria.
2020-01-01Nanotheranostics
Effects of molecular weight and structural conformation of multivalent-based elastin-like polypeptides on tumor accumulation and tissue biodistribution
Article
作者: Seo, Bo-Yeon ; Kim, Sang Kyoon ; Sarangthem, Vijaya ; Cheon, Sun-Ha ; Park, Rang-Woon ; Lee, Byung-Heon ; Lee, Young-Jin ; Yi, Aena ; Singh, Thoudam Debraj
In order to improve clinical outcomes for novel drug delivery systems, distinct optimization of size, shape, multifunctionality, and site-specificity are of utmost importance. In this study, we designed various multivalent elastin-like polypeptide (ELP)-based tumor-targeting polymers in which multiple copies of IL-4 receptor (IL-4R)-targeting ligand (AP1 peptide) were periodically incorporated into the ELP polymer backbone to enhance the affinity and avidity towards tumor cells expressing high levels of IL-4R. Several ELPs with different molecular sizes and structures ranging from unimer to micelle-forming polymers were evaluated for their tumor accumulation as well as in vivo bio-distribution patterns. Different percentages of cell binding and uptake were detected corresponding to polymer size, number of targeting peptides, or unimer versus micelle structure. As compared to low molecular weight polypeptides, high molecular weight AP1-ELP showed superior binding activity with faster entry and efficient processing in the IL-4R-dependent endocytic pathway. In addition, in vivo studies revealed that the high molecular weight micelle-forming AP1-ELPs (A86 and A100) displayed better tumor penetration and extensive retention in tumor tissue along with reduced non-specific accumulation in vital organs, when compared to low molecular weight non-micelle forming AP1-ELPs. It is suggested that the superior binding activities shown by A86 and A100 may depend on the multiple presentation of ligands upon transition to a micelle-like structure rather than a larger molecular weight. Thus, this study has significance in elucidating the different patterns underlying unimer and micelle-forming ELP-mediated tumor targeting as well as the in vivo biodistribution.
100 项与 盐酸阿替卡因/重酒石酸肾上腺素 相关的药物交易
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外链
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 麻醉 | 德国 | 1976-01-01 |
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 炎症性疼痛 | 临床前 | 美国 | - | - |
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