LY32262(LY32262) - _专利_临床

概要

基本信息

药物类型

小分子化药

别名

靶点-

作用方式-

作用机制-

治疗领域

肿瘤

在研适应症-

非在研适应症

肿瘤

原研机构

Wayne State University School of Medicine

在研机构-

非在研机构

Wayne State University School of Medicine

权益机构-

最高研发阶段无进展临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构/序列

分子式C13H9Cl2NO3S

InChIKeyTXHQSKPOVJIXCS-UHFFFAOYSA-N

CAS号477844-46-5

关联

100 项与 LY32262 相关的临床结果

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100 项与 LY32262 相关的转化医学

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100 项与 LY32262 相关的专利（医药）

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7

项与 LY32262 相关的文献（医药）

2019-12-01·Synthesis

Improvements of C–H Radio-Iodination of N-Acylsulfonamides toward Implementation in Clinics

作者: Babin, Victor ; Benoist, Florian ; Bouillon, Jean-Philippe ; Dubost, Emmanuelle ; Hébert, Alexandra ; Cailly, Thomas ; Fabis, Frédéric ; Pigrée, Gilbert

An improved protocol to perform C–H radio-iodination is described. These new conditions allow rapid and clean formation of radio-iodinated N-acylsulfonamides using [125I]NIS and catalytic amounts of palladium acetate and para-toluenesulfonic acid. No pre-functionalized precursors are required and the products are obtained with radiochemical conversions (RCC) of 27–84%.

2018-10-05·Organic Letters1区 · 化学

Palladium-Mediated Site-Selective C–H Radio-iodination

1区 · 化学

Article

作者: Babin, Victor ; Manrique, Alain ; Benoist, Florian ; Fabis, Frédéric ; Chollet, Céline ; Bouillon, Jean-Philippe ; Barbey, Pierre ; Dubost, Emmanuelle ; Cailly, Thomas ; Hébert, Alexandra ; Pieters, Grégory

The palladium-mediated C-H radio-iodination of arenes using sodium iodide as the primary isotopic source is reported and performed without chemical know-how in 30 min and applied to the synthesis of complex radio-iodinated compounds of biological interest.

2007-07-01·Tetrahedron Letters

An expeditious and convenient synthesis of acylsulfonamides utilizing polymer-supported reagents

作者: Kathy Sarris ; Daryl R. Sauer ; Ying Wang ; Stevan W. Djuric

Acylsulfonamides can be rapidly and conveniently synthesized from a variety of carboxylic acids and sulfonamides utilizing the com. available reagents, PS-DCC and DMAP under mild reaction conditions.DMAP can be efficiently scavenged by utilization of a silica-supported tosic acid cartridge (Si-SCX).In most of the cases studied, products with high purities and yields were obtained without the need for further purification

100 项与 LY32262 相关的药物交易

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