The purpose of this study is to compare the efficiency and safety of the treatment against sting scorpion, using two serums, one elaborated by Birmex versus other commercial serum

开始日期2008-08-01

申办/合作机构

Laboratorios de Biologicos y Reactivos de Mexico SA de CV

100 项与 Serum antiscorpion 相关的临床结果

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100 项与 Serum antiscorpion 相关的转化医学

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100 项与 Serum antiscorpion 相关的专利（医药）

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项与 Serum antiscorpion 相关的文献（医药）

2012-06-01·Revista da Sociedade Brasileira de Medicina Tropical4区 · 医学

Scorpion sting-induced unilateral pulmonary edema

4区 · 医学

ArticleOA

作者: Maia, Bruna Tupinambá ; Gonçalves, Eduardo ; Martelli Júnior, Hercílio

ABSTRACT A five-year-old male was admitted to the emergency department of the reference hospital with severe tachydyspnea and tachycardia, two hours after being stung by a scorpion. According to the radiographic findings, the patient was diagnosed with asymmetrical acute pulmonary edema (APE), which struck predominantly the right hemithorax. The treatment consisted of ventilatory support and intravenous administration of antiscorpion serum, furosemide and dobutamine. By the tenth day in hospital, the patient was discharged in good condition. This case report aims to emphasize the occurrence of asymmetric APE within the first few hours after scorpion poisoning.

2009-01-01·Clinical Toxicology3区 · 医学

Serum levels and urine detection ofCentruroides sculpturatusvenom in significantly envenomated patients

3区 · 医学

Article

作者: Leslie Boyer-Hassen ; Jude McNally ; Andreas A Theodorou ; Frank Gardner Walter ; Alejandro Alagon ; H L Vazquez ; Peter Chase

INTRODUCTIONEnvenomation by Centruroides sculpturatus can cause systemic signs and symptoms requiring treatment. The toxicokinetics of C. sculpturatus venom has not been described.METHODSVenom components were separated for cross-reactivity testing. Serum and urine collected from three patients envenomated by C. sculpturatus had venom levels determined by sandwich enzyme-linked immunosorbent assay (ELISA).RESULTSWestern blot analysis indicated recognition of C. sculpturatus venom by Alacramyn, an equine F(ab')(2) antivenom developed against Centruroides scorpion venoms, including C. sculpturatus. Serum venom levels in ng/mL with post-envenomation times in minutes (min) were as follows: 85-year-old woman = 8.2 (approximately 150), 2.8 (515), 1.6 (1,200); 14-month-old girl = 29.7 (approximately 50), 5.0 (729); 3-year-old girl = 11.1 (approximately 313), urine venom level of 9.0 (approximately 490).CONCLUSIONThere is sufficient venom cross-antigenicity among different Centruroides species to allow this ELISA technique with Alacramyn to determine serum and urine C. sculpturatus venom concentrations in envenomated patients.

2005-12-01·Toxicon3区 · 医学

Pharmacokinetics of a F(ab′)2 scorpion antivenom in healthy human volunteers

3区 · 医学

Article

作者: C. Sevcik ; W. García-Ubbelohde ; J. Paniagua-Solís ; A. Alagón ; R. Mancilla-Nava ; A. Chávez-Haro ; H. Vázquez

This paper presents the first study of F(ab')2 scorpion antivenom pharmacokinetics in humans. We have studied the pharmacokinetics of an antiscorpion venom preparation (Alacramyn) in eight human healthy volunteers. The fabotherapic was administered as a 47.5 mg i.v. bolus. Blood samples were drawn at 0, 5, 15, 30, 45, 60, 90, 120, 180 and 360 min after antivenom administration. Subsequently, the volunteers made seven visits to the hospital. Four of them at 24 h intervals, one at day 10, and one at day 21. We measured antivenom plasmatic concentrations using a specific high sensitivity ELISA method for F(ab')2. The time course of F(ab')2 in serum of seven subjects was well described by a lineal combination of three exponential components; a four exponential component model was necessary to fit the eighth subject. The most significant antivenom pharmacokinetic parameters determined were: AUC(infinity)=596.9 (369.3, 891.2) mg h l(-1); V(c) = 3.1 (2.3, 4.3)l; V(ss) = 15.4 (12.8, 39.9)l; MRT = 250.0 (218.8, 310.2) h; CL = 96.6 (58.0, 139.2) ml h(-1); t(1/2,tau1) (also called t(1/2,alpha)) = 0.25 (0.13, 0.37) h; t(1/2,tau(z)) (corresponding to the slowest component) = 161.3 (141.0, 212.0) h.

100 项与 Serum antiscorpion 相关的药物交易

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