作者: Youn, So-Yeon ; Kim, Kwan Mook ; Kim, Gyoungmi ; Yoon, Juyoung ; Cha, Sun-Shin ; Nam, Ki Taek ; Kim, Yujin ; Shirbhate, Mukesh Eknath ; Jeong, Haengdueng ; Yang, Mengyao ; Uhm, Chanyang

The accumulation of photosensitizers (PSs) in lesion sites but not in other organs is an important challenge for efficient image guiding in photodynamic therapy. Cancer cells are known to express a significant number of albumin-binding proteins that take up albumin as a nutrient source. Here, we converted albumin to a novel BODIPY-like PS by generating a tetrahedral boron environment via a flick reaction. The formed albumin PS has almost the same 3-dimensional structural feature as free albumin because binding occurs at Sudlow Site 1, which is located in the interior space of albumin. An i.v. injection experiment in tumor-bearing mice demonstrated that the human serum albumin PS effectively accumulated in cancer tissue and, more surprisingly, albumin PS accumulated much more in the cancer tissue than in the liver and kidneys. The albumin PS was effective at killing tumor cells through the generation of reactive oxygen species under light irradiation. The crystal structure of the albumin PS was fully elucidated by X-ray crystallography; thus, further tuning of the structure will lead to novel physicochemical properties of the albumin PS, suggesting its potential in biological and clinical applications.

2024-11-01·Burns

Early high-volume resuscitation with crystalloid solution combined with albumin – Pragmatic advice

Letter

作者: Burge, T S ; Burge, TS

2024-09-01·Journal of Neurosurgery: Spine

The impact of serum albumin levels on postoperative complications in lumbar and cervical spine surgery: an analysis of the Michigan Spine Surgery Improvement Collaborative registry

Article

作者: Easton, Richard ; Tong, Doris ; Schultz, Lonni ; Telemi, Edvin ; Chang, Victor ; Abdulhak, Muwaffak ; Perez-Cruet, Miguelangelo ; Schwalb, Jason M. ; Kim, Enoch ; Nerenz, David R. ; Mansour, Tarek R. ; Khalil, Jad G. ; Park, Paul ; Aleem, Ilyas ; Soo, Teck ; Brennan, Matthew ; Easton, Matthew ; Jafar, Yousif ; Hu, Jianhui ; Chaker, Anisse N. ; Rademacher, Anneliese F.

OBJECTIVEPatients with serum albumin levels < 3.5 g/dL are considered malnourished, but there is a paucity of data regarding the outcomes of patients with albumin levels > 3.5 g/dL. The objective of this study was to evaluate the effect of albumin on postoperative outcome in patients undergoing elective cervical and lumbar spine procedures.METHODSThe Michigan Spine Surgery Improvement Collaborative database was queried for lumbar and cervical fusion surgeries between January 2020 and December 2022. Patients were grouped by preoperative serum albumin levels: < 3.5 g/dL, 3.5–3.7 g/dL, 3.8–4.0 g/dL, and > 4.0 g/dL. Primary outcomes included urinary retention, ileus, dysphagia, surgical site infection (SSI), readmission within 30 and 90 days, return to the operating room, and length of stay (LOS) ≥ 4 days. Multivariate analysis was conducted to adjust for potential confounders.RESULTSThis study included 15,629 lumbar cases and 6889 cervical cases. Within the lumbar cohort, an albumin level of 3.5–3.7 g/dL was associated with an increased risk of readmission at 30 days (p = 0.048) and 90 days (p = 0.005) and an LOS ≥ 4 days (p < 0.001). An albumin level of 3.8–4.0 g/dL was associated with an increased risk of an LOS ≥ 4 days (p < 0.001). Within the cervical cohort, an albumin level of 3.5–3.7 g/dL was associated with an increased risk of SSI (p = 0.023), readmission at 30 days (p < 0.002) and 90 days (p < 0.001), return to the operating room (p = 0.002), and an LOS ≥ 4 days (p < 0.001). An albumin level of 3.8–4.0 g/dL was associated with an increased risk of readmission at 30 days (p = 0.012) and 90 days (p = 0.001) and an LOS ≥ 4 days (p < 0.001).CONCLUSIONSThis study maintains that patients with hypoalbunemia undergoing spine surgery are at risk for postoperative adverse events. However, there also exist significant associations between borderline serum albumin levels of 3.5–4.0 g/dL and increased risk of postoperative adverse events.

100 项与 Albumin(IDIBAPS) 相关的药物交易

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