F-041

The amino acid sequence of the antitumor protein neocarzinostatin, isolated from Streptomyces carzinostaticus var. F-41, was determined by sequence anal. of tryptic peptides and fragments obtained by digestion of the protein with chymotrypsin, pepsin, acid protease, and dilute HCl.Neocarzinostatin consists of 109 amino acid residues and its mol. weight calculated from the proposed structure, is 10,717.